The role of probiotic bacteria in managing periodontal disease: a systematic review

Matsubara, Victor Haruo; Bandara, Nihal; Ishikawa, Kenzo; Mayer, Márcia Pinto Alves; Samaranayake, LP

doi:10.1080/14787210.2016.1194198

Cited by 122 publications

(93 citation statements)

References 54 publications

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“…Traditional therapies are mainly professional removal of dental plaque and antibiotics treatment, but the ability of oral pathogens to re‐colonize as well as the emerging resistance to antibiotics is leading a call to the development of new treatments against these microbial‐derived oral diseases . Among alternative therapies, the use of probiotics‐containing products is being tested as a new strategy to prevent oral diseases …”

Section: Discussionmentioning

confidence: 99%

In vitro beneficial effects of Streptococcus dentisani as potential oral probiotic for periodontal diseases

Esteban‐Fernández

Ferrer

Zorraquín‐Peña

et al. 2019

Journal of Periodontology

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Background Periodontal diseases are of high prevalence globally and are characterized by an exacerbated inflammatory response which leads to oral tissue destruction. The use of probiotics is widely extended in the case of gastrointestinal disorders; however, their use in microbial‐origin oral diseases is still preliminary. Methods We used quantitative polymerase chain reaction to determine the levels of the oral bacterium Streptococcus dentisani 7746 in the tongue, saliva, supragingival, and subgingival plaque. We explore the potential benefits of this probiotic by measuring inhibition of the periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum growth and attachment to human gingival fibroblasts. In addition, its anti‐inflammatory activity against cytokines secretion induced by these pathogens was determined in an in vitro model by enzyme‐linked immunosorbent assay. Results We report that S. dentisani is found at high levels in the gingival crevice. Data show a strong inhibitory action of S. dentisani supernatant against the periodontal pathogens in pure culture. S. dentisani attached to gingival cells in vitro, inhibiting periodontal pathogens by competition, adherence, and displacement mechanisms. Finally, in a simple in vitro model, the oral probiotic strongly increased the secretion of the anti‐inflammatory cytokine IL‐10 after incubations with P. gingivalis and F. nucleatum, as well as significantly reduced the expression of interferon‐γ induced by F. nucleatum. Conclusion Altogether, these results highlight the potential of S. dentisani as adjuvant therapy in the management of periodontal diseases, whose efficacy will need to be tested in clinical studies.

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Section: Discussionmentioning

confidence: 99%

In vitro beneficial effects of Streptococcus dentisani as potential oral probiotic for periodontal diseases

Esteban‐Fernández

Ferrer

Zorraquín‐Peña

et al. 2019

Journal of Periodontology

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“…Probiotics are defined by the World Health Organization as "live microorganisms that can provide benefits to human health when administered in adequate amounts, which confer a beneficial health effect on the host" [Joint FAO/WHO Working Group, 2002]. The application of probiotics has been shown to reduce the growth and production of toxic products in opportunistic pathogens, but its beneficial health effects are yet to be confirmed [Matsubara et al, 2016;Gruner et al, 2016].…”

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confidence: 99%

Factors Influencing the Competition between Streptococcus oligofermentans and Streptococcus mutans in Dual-Species Biofilms

et al. 2017

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Previous studies have shown that Streptococcus oligofermentans inhibits the growth of cariogenic Streptococcus mutans in biofilms in vitro and is considered a probiotic candidate for caries prevention. This study aimed to examine the effects of various environmental factors on the competition between S. oligofermentans and S. mutans in a dual-species biofilm model. Single or dual S. oligofermentans and S. mutans biofilms were grown in a 96-well active attachment model for 48 h. Several growth conditions were examined in the model, namely: S. oligofermentans was inoculated 24 h before S. mutans or vice versa; the growth medium was supplemented with 0.2% sucrose or 0.4% glucose; biofilms were grown under a constantly neutral pH or pH-cycling condition, which included 8 h of neutral pH and 16 h of pH 5.5. The 48-h biofilms were examined for viable cell counts and lactic acid and hydrogen peroxide production ability. When S. oligofermentans was inoculated first, it clearly inhibited the growth of S. mutans and reduced the biofilm lactic acid production by up to 8-fold through hydrogen peroxide production, independently of sugar supply and pH conditions. When S. mutans was inoculated first, the level of inhibition by S. oligofermentans varied depending on the sugar supply and pH conditions. Thus, the inhibition efficacy of S. oligofermentans against S. mutans in dual-species biofilms is influenced by environmental factors. This study provides practical information on how to maximize the efficacy of S. oligofermentans.

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“…There was a significant reduction in probing pocket depth, bleeding on probing, plaque index and attachment gain in probiotic group [116]. In the studies where L. reuteri was selected as probiotic, the reduction of probing pocket depth was 1.31-1.74 mm in probiotic group and 0.49-1.39 mm in placebo group.…”

Section: Probiotics and Periodontitismentioning

confidence: 82%

“…Finally, the authors concluded that oral administration of probiotics is a safe and effective adjunct to scaling and root planning in the treatment of chronic periodontitis. Their adjunctive use is likely to improve diseases indices and reduce the need for antibiotics [116].…”

Section: Probiotics and Periodontitismentioning

confidence: 99%

“…Several clinical trials were conducted in order to study the effect of administration of probiotics in initial treatment of periodontitis [114][115][116][117]. The bacteria most frequently used as probiotic are L. reuteri (DSM 17938 + ATCC PTA 5289) [72,[118][119][120], Lactibacillus salivarius WB21 [121,122], L. reuteri (ATCC 55730 + ATCC PTA 5289) [123], L. reuteri (ATCC PTA 5289) [61], Streptoccus oralis KJ3 + Streptococcus uberis KJ2 + Streptoccus rattus JH145 [124] and L. rhamnosus SP1 [125].…”

Section: Probiotics and Periodontitismentioning

confidence: 99%

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Probiotics and Periodontal Diseases

Morales¹,

Bravo²,

Bedoya³

et al. 2017

Insights Into Various Aspects of Oral Health

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Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Probiotics have been used to directly modify the resident oral microbiome and proposed to modulate immune responses. In dentistry, probiotics have been employed as useful adjuncts for the reduction of caries development, suppressing oral Candida infection and controlling halitosis. Plaque-induced gingivitis is a gingival inflammation caused by the adherent bacterial biofilm around teeth. Gingivitis and periodontitis are considered to be a continuum of the same inflammatory process, although many gingivitis lesions do not progress to periodontitis. Periodontitis is an inflammatory process that affects the attachment structures of teeth. It constitutes a second cause of tooth loss worldwide. Conventional treatment modalities of periodontal disease include non-surgical and/or surgical management, with an emphasis on mechanical debridement. However, mechanical debridement as a sole therapy is not always effective to improve clinical parameters. A growing number of studies support probiotic therapy to prevent or treat gingivitis and periodontitis. Oral administration of probiotics is an effective adjunct in reducing pathogenic bacteria and improving clinical signs of disease. Probiotics may serve as adjunct or replacement therapy substitute antibiotics in managing human periodontal infections in future.

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The role of probiotic bacteria in managing periodontal disease: a systematic review

Cited by 122 publications

References 54 publications

In vitro beneficial effects of Streptococcus dentisani as potential oral probiotic for periodontal diseases

In vitro beneficial effects of Streptococcus dentisani as potential oral probiotic for periodontal diseases

Factors Influencing the Competition between <b><i>Streptococcus oligofermentans </i></b>and <b><i>Streptococcus mutans </i></b>in Dual-Species Biofilms

Probiotics and Periodontal Diseases

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