Clinical Effects of Drug Resistant Enterococcus-Preparation on Infectious Diarrhea

Abstract

It is well known that in the course of antibiotic treatment there sometimes occur alterations in enteral bacterial populations and superinfections as a results of the disruption of the usual enteral bacterial flora.It is also recognized that the certain bacterial flora such as enterococci can provide the host animals with the resistance to some intestinal infections such as salmonellosis.The authors tried Entomol-San, an antibiotic resistant enterococcus (streptococcas faecalis BIO-4R) preparation on patients of bacillary dysentery, its suspects, and salmonellosis and its clinical effects were evaluated in this paper.Entomol-San was administrated in combination with antibiotics and its eradication effects on Shigella and Salmonellae were compared with the control (cases with antibiotic only). Recognizable differences were not observed between them. However, in the effects to the normalization of the stool appearances Entomol-San yielded better results than antibiotic alone. In the cases with Entomol-San and antibiotics, the mean requiring day for the normalization of stool appearances was 3.3 in 11 dysentery cases, 5.63 in 11 salmonellosis, and 3.47 in 15 cases of acute enteritis without known pathogens. These data appeared obviously superior to the results obtained by the 1971's study team in antibiotic therapy of intestinal infectious diseases.Further, the bacteriological investigations revealed that BIO-4R strains could often be recovered from the feces of the patients after Entomol-San administrations. In the mixed culture, the drug resistance of BIO-4R was not transferred into Escherichia coli K-12 strains,

Growth of Enterococcus faecalis (Streptococcus faecalis) BIO-4R in the Intestinal Tract of Animals and Humans

“…This strain is nonpathogenic (10) and has been used clinically to prevent patients from bowel complaint during treatment with antibiotics (2)(3)(4)(5)9) . The organism has also been used to stabilize the lactic flora and to suppress the putrefactive microbes in the intestine of farm animals receiving antimicrobial agents for promoting agents (8).…”

Evidence That the Multi‐Drug‐Resistance of Streptococcus faecalis BIO‐4R Is Not Carried by a Plasmid

“…5, indicate that ribosomes from S. faecalis BIO are themselves resistant to streptomycin. DISCUSSION S. ,faecalis BIO-4R is a multi-drug-resistant strain isolated by Meguro and Ozawa (7) and it has been widely used clinically (3,4,14,19,21). On oral administration to germ-free mice this organism colonized the intestinal tract (2) and it also suppressed the proliferation of intestinal pathogenic organisms in mice during antibiotic Fig.…”