Evidence That the Multi‐Drug‐Resistance of <i>Streptococcus faecalis</i> BIO‐4R Is Not Carried by a Plasmid

Yamashita, Yutaka; Ozawa, Katsura; Takeda, Yoshifumi; Miwatani, Toshio

doi:10.1111/j.1348-0421.1977.tb02811.x

Cited by 3 publications

(6 citation statements)

References 17 publications

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“…) is a nontransferable multi-drug-resistant strain of lactic acid bacteria (11) . This strain is nonpathogenic (10) and has been used clinically to prevent patients from bowel complaint during treatment with antibiotics (2)(3)(4)(5)9) .…”

Section: Enterococcus Faecalis Bio-4r (Until Recently Classified As Smentioning

confidence: 99%

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Growth of Enterococcus faecalis (Streptococcus faecalis) BIO-4R in the Intestinal Tract of Animals and Humans

Ozawa

1985

Bifidobacteria Microflora

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Section: Enterococcus Faecalis Bio-4r (Until Recently Classified As Smentioning

confidence: 99%

“…The BIO-4R -showed resistance to penicillins, cephalosporins, tetracycline drugs, chloramphenicol , 15 macrolides, aminoglycosides, and sulfonamides (11).…”

Section: History Of E Faecalis Bio-4r (11)mentioning

confidence: 99%

Growth of Enterococcus faecalis (Streptococcus faecalis) BIO-4R in the Intestinal Tract of Animals and Humans

Ozawa

1985

Bifidobacteria Microflora

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“…The purpose of this study was to examine whether Streptococcus faecalis 28,30), an antibiotic-resistant lactic acid bacterium, can influence the intestinal flora of farm animals which have been receiving antibiotics and other antimicrobial agents.…”

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confidence: 99%

Effect of Streptococcus faecalis BIO-4R on intestinal flora of weanling piglets and calves

Ozawa¹,

Yabuuchi²,

Yamanaka³

et al. 1983

Appl Environ Microbiol

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The effect of oral administration of Streptococcusfaecalis BIO-4R, an antibiotic-resistant lactic acid bacterium, on the intestinal flora of weanling piglets and cows reared on antibiotic-containing diet was investigated. Fourteen days after administration of the bacteria, the intestinal flora of the piglets was examined. Animals of the administered group had stabilized lactic flora such as bifidobacteria, streptococci, and lactobacilli, whereas most animals of control group had reduced lactic flora. On the other hand, abundant yeasts were detected from the cecum, colon, and feces of the control animals, but the levels were significantly lower in the animals given strain BIO-4R. The density of Salmonella in the intestine appeared to be reduced after the administration of strain BIO-4R. The number of BIO-4R cells was shown to be 10 times lower in the duodenum and jejunum than in the ileum, suggesting that strain BIO-4R might have grown transiently in the ileum. The similar trend toward stabilization of the lactic flora was also observed in cows after administration of BIO-4R. In addition, an antagonistic effect of the strain against yeasts and Salmonella was suggested. These findings indicate that the oral administration of strain BIO-4R is one of the useful methods whereby the potentially deleterious effect of antibiotics on the intestinal flora of farm animals may be minimized.

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“…We also examined whether Streptcocus faecalis strain BIO-4R (15,18), a multi-drug resistant strain previously reported to show in vivo and in vitro antifungal effects, was also antagonistic to C. albicans in the CF system. Strains.…”

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confidence: 99%

“…The former is an old stock culture and the latter is a fresh isolate from the bile of a patient with cholecystitis. Streptcocus faecalis strain BIO-4R (BIO-4R) is a multi-drug resistant strain described previously (15,18). Escherichia coli COM was isolated from human feces.…”

mentioning

confidence: 99%

Antagonistic Effects of Bacillus natto and Streptococcus faecalis on Growth of Candida albicans

Ozawa

Yabuuchi

Yamanaka

et al. 1979

Microbiology and Immunology

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The growth-inhibitory effects of Bacillus natto and Streptococcus faecalis on Candida albicans were investigated. When inoculated into the filtrate of a long-term culture of B. natto strain BN (BN), a stock culture of C. albicans RIMD 0301020 lost its viability completely, whereas C. albicans RIMD 0301011, a fresh isolate from a clinical source, did not. In continuous flow (CF) culture the growth of both strains of C. albicans was suppressed by mixed cultivation with BN. On the other hand, in classical batch culture BN did not suppress the growth of C. albicans. S. faecalis BIO-4R, a multi-drug resistant strain, was also antagonistic to C. albicans RIMD 0301011 but symbiotic with BN in CF culture. These findings suggest that BN in concert with S. faecalis BIO-4R may inhibit the growth of C. albicans in the intestinal tract.

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Evidence That the Multi‐Drug‐Resistance of Streptococcus faecalis BIO‐4R Is Not Carried by a Plasmid

Cited by 3 publications

References 17 publications

Growth of Enterococcus faecalis (Streptococcus faecalis) BIO-4R in the Intestinal Tract of Animals and Humans

Growth of Enterococcus faecalis (Streptococcus faecalis) BIO-4R in the Intestinal Tract of Animals and Humans

Effect of Streptococcus faecalis BIO-4R on intestinal flora of weanling piglets and calves

Antagonistic Effects of Bacillus natto and Streptococcus faecalis on Growth of Candida albicans

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