Clinical Decision-Making in the Management of Multiple Sclerosis

Rizvi, Syed; Stone, Joshua A.; Chaudhry, Saima; Haddad, Nichola; Wong, Brian; Grimes, Jennifer O.

doi:10.1007/978-3-030-24436-1_8

Cited by 3 publications

(3 citation statements)

References 130 publications

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“…N, N-Dimethyltryptamine (DMT) has been shown to reduce the frequency of relapses but shows no effects on progressive MS or axonal damage. In addition, the reported efficacy, tolerability, and safety of DMT have varied between moderate and high levels, and continued treatments have been limited by the risk of severe side effects, including cardiomyopathy [ 125 , 126 ].…”

Section: Recent Advances In the Treatment Of Neurological Disordermentioning

confidence: 99%

Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives

Rahman

Islam

et al. 2022

Biology

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Neurodegenerative diseases are a global health issue with inadequate therapeutic options and an inability to restore the damaged nervous system. With advances in technology, health scientists continue to identify new approaches to the treatment of neurodegenerative diseases. Lost or injured neurons and glial cells can lead to the development of several neurological diseases, including Parkinson’s disease, stroke, and multiple sclerosis. In recent years, neurons and glial cells have successfully been generated from stem cells in the laboratory utilizing cell culture technologies, fueling efforts to develop stem cell-based transplantation therapies for human patients. When a stem cell divides, each new cell has the potential to either remain a stem cell or differentiate into a germ cell with specialized characteristics, such as muscle cells, red blood cells, or brain cells. Although several obstacles remain before stem cells can be used for clinical applications, including some potential disadvantages that must be overcome, this cellular development represents a potential pathway through which patients may eventually achieve the ability to live more normal lives. In this review, we summarize the stem cell-based therapies that have been explored for various neurological disorders, discuss the potential advantages and drawbacks of these therapies, and examine future directions for this field.

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Section: Recent Advances In the Treatment Of Neurological Disordermentioning

confidence: 99%

Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives

Rahman

Islam

et al. 2022

Biology

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“…However, contrary to favorable impact of DMT drugs on relapsing MS by preventing the frequency of relapses, they have limited benefit on progressive MS and axonal damage. Also, efficacy, tolerability, and safety of DMT vary between moderate to high levels and even in cases that are very effective, continuing treatment is limited by the risk of serious side effects including cardiomyopathy [219,220]. New immunemodulating approaches including stem cell transplantation have emerged in regenerative medicine for the treatment of inflammation-associated diseases.…”

Section: Therapeutic Potential Of Stem Cell-derived Exosome In Multipmentioning

confidence: 99%

Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment

et al. 2021

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Short-term symptomatic treatment and dose-dependent side effects of pharmacological treatment for neurodegenerative diseases have forced the medical community to seek an effective treatment for this serious global health threat. Therapeutic potential of stem cell for treatment of neurodegenerative disorders was identified in 1980 when fetal nerve tissue was used to treat Parkinson's disease (PD). Then, extensive studies have been conducted to develop this treatment strategy for neurological disease therapy. Today, stem cells and their secretion are well-known as a therapeutic environment for the treatment of neurodegenerative diseases. This new paradigm has demonstrated special characteristics related to this treatment, including neuroprotective and neurodegeneration, remyelination, reduction of neural inflammation, and recovery of function after induced injury. However, the exact mechanism of stem cells in repairing nerve damage is not yet clear; exosomes derived from them, an important part of their secretion, are introduced as responsible for an important part of such effects. Numerous studies over the past few decades have evaluated the therapeutic potential of exosomes in the treatment of various neurological diseases. In this review, after recalling the features and therapeutic history, we will discuss the latest stem cell-derived exosome-based therapies for these diseases.

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“…MS etiology is unclear, but several studies have already shown that causative agents of MS is reliant on a strong genetic factor (Akkad et al, 2009). Several different methods have been used to determine the genetic bases of MS, such as genetic linkage, gene expression and candidate ZANCO Journal of Pure and Applied Sciences 2021 gene association (Gregory et al, 2007, Rizvi et al, 2020. Amongst the association study is a viable approach toward recognizing the risk genetic loci of genes as a marker such as SNP.…”

Section: Introductionmentioning

confidence: 99%

Molecular Study of IL-7R Gene Polymorphism and their Associations with Male Multiple Sclerosis Patients in Erbil Province.

Smail¹

2021

ZJPAS

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Multiple sclerosis (MS) is an autoimmune disease in which immune cells attacks the body cells mistakenly; it is characterized by chronic inflammation that leads to demyelination and conduction of nerve impulse is affected negatively. The cause of the disease is unknown, but it may be partially under the control of genetics, including interleukin 7 receptor alpha (IL7Rα). In this case-control study, 40 relapsing-remitting MS (RRMS) male patients, which fulfills McDonald criteria and 40 healthy controls, with matched sex, were compared depending on the rs6897932 polymorphism within the exon 6 of IL7Rα gene by Tetra-amplification refractory mutation system polymerase chain reaction (Tetra-ARMS-PCR) method. The frequency of T allele of IL7Rα rs6897932 was considerably higher in male MS patients than healthy control males (31.25 vs 17.5%). Genotype distributions of the single nucleotide polymorphism (SNP) rs6897932 deviated from Hardy-Weinberg equilibrium with a p-value of 0.80. Both homozygous (TT) and Heterozygous (CT) were non-significantly positively associated with MS male patients (OR = 6.75, 95%CI = 0.73-62.4, p = 0.059, OR = 1.68, 95%CI = 0.64-4.38, p = 0.28) respectively. The distribution of the rs6897932 polymorphism is not significantly different in our case/control study in the Erbil province.

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Clinical Decision-Making in the Management of Multiple Sclerosis

Cited by 3 publications

References 130 publications

Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives

Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives

Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment

Molecular Study of IL-7R Gene Polymorphism and their Associations with Male Multiple Sclerosis Patients in Erbil Province.

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