Clinical correlates of endothelial function in chronic heart failure

Abstract

This study demonstrates that a better functional status and absence of diabetes mellitus are associated to higher FMD regardless of the etiology of the cardiac disease.

Chronic protection against ischemia and reperfusion-induced endothelial dysfunction during therapy with different organic nitrates

“…Some limitations need to be acknowledged: first, healthy subjects were enrolled, and the peripheral circulation was tested in this experimental model. Although abnormalities in FMD have been shown in many conditions [28][29][30][31][32][33], like for any model, the translation of the present data to the clinical setting (patients with coronary artery disease, coronary or cerebral circulation) needs to be further investigated. Similarly, the data from isolated endothelial cells should not be automatically transferred to the clinical/ human in vivo setting, and additional mechanisms could explain our observations, even though we previously showed human in vivo ALDH-2 inhibition in response to GTN [34].…”

Insulin resistance and endothelial function in children and adolescents

“…Reactive hyperemia was calculated as the ratio of the change in diameter (maximal dilatation after deflation-baseline) divided by the baseline value, which corresponds to the maximum FMD recovery value. FMD was analyzed as the percentage increase in brachial artery diameter after the application of a pressure stimulus [22]. Intra-observer variability was 0.93 according to the ICC (intraclass correlation coefficient, good if N0.80) [20].…”

Endothelial and Metabolic Function Interactions in Overweight/Obese Children:

“…Reactive hyperaemia was calculated as the ratio of the change in diameter (maximal dilatation after deflation-baseline) divided by the baseline value, which corresponds to the maximum FMD recovery value. FMD was analyzed as the percentage increase in brachial artery diameter after the application of a pressure stimulus 28) . Intraobserver variability was 0.95 according to ICC (good if 0.80) 26) .…”