Clinical comparison of cefuroxime axetil and amoxicillin/clavulanate in the treatment of patients with acute bacterial maxillary sinusitis

Camacho, Alfonso E.; Cobo, Roxana; Otte, Jorge; Spector, Sheldon L.; Lerner, Charles; Garrison, Norman; Miniti, Aroldo; Mydlow, Patricia K.; Giguere, Gregory; Collins, Jeffrey J.

doi:10.1016/0002-9343(92)90232-z

Cited by 58 publications

(19 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Three other 10-day treatment clinical trials comparing cefuroxime axetil and amoxicillin-clavulanate (4,15,32), including the largest one performed to date (317 patients) (4), have previously reported therapeutically effective regimens of cefuroxime axetil tablets to be associated with significantly fewer drug-related adverse events, particularly diarrhea and other gastrointestinal events, than was amoxicillin-clavulanate. Similarly, when 10-day treatments with the suspension formulation of the two drugs were compared for more than 600 pediatric patients with acute otitis media (22,28), cefuroxime axetil resulted in significantly fewer drug-related adverse events, particularly diarrhea.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of short-course therapy (5 days) with cefuroxime axetil in treatment of secondary bacterial infections of acute bronchitis

Henry

Ruoff

Rhudy

et al. 1995

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Five hundred thirty-seven patients were enrolled in two independent, investigator-blinded, multicenter, randomized clinical trials comparing the clinical and bacteriologic efficacies and the safety of 5-or 10-day treatment with cefuroxime axetil with those of 10-day treatment with amoxicillin-clavulanate in the treatment of secondary bacterial infections of acute bronchitis. Patients received either 5 or 10 days of treatment (n ‫؍‬ 177 in each group) with cefuroxime axetil at 250 mg twice daily or 10 days of treatment (n ‫؍‬ 183) with amoxicillinclavulanate at 500 mg three times daily. Patients in the cefuroxime axetil (5 days) group received placebo on days 6 to 10. Bacteriologic assessments were based on sputum specimen cultures obtained preceding and, when possible, following treatment. Organisms were isolated from the pretreatment sputum specimens of 242 of 537 (45%) patients, with the primary pathogens being Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Streptococcus pneumoniae, and Staphylococcus aureus (28, 25, 13, 9, and 8% of isolates, respectively). Pathogens were eradicated or presumed to be eradicated in 87% (52 of 60), 91% (53 of 58), and 86% (60 of 70) of bacteriologically evaluable patients treated with cefuroxime axetil (5 days), cefuroxime axetil (10 days), and amoxicillin-clavulanate, respectively. A satisfactory clinical outcome (cure or improvement) was achieved in 82% (107 of 130), 86% (117 of 136), and 83% (130 of 157) of the clinically evaluable patients treated with cefuroxime axetil (5 days), cefuroxime axetil (10 days), and amoxicillin-clavulanate, respectively. Treatment with amoxicillin-clavulanate was associated with a significantly higher incidence of drug-related adverse events than was treatment with cefuroxime axetil for either 5 or 10 days (P ‫؍‬ 0.001), primarily reflecting a higher incidence of drug-related gastrointestinal adverse events (37 versus 19 and 15%, respectively; P < 0.001), particularly diarrhea and nausea. These results indicate that treatment with cefuroxime axetil at 250 mg twice daily for 5 days is as effective as treatment for 10 days with either the same dose of cefuroxime axetil or amoxicillin-clavulanate at 500 mg three times daily in patients with acute bronchitis. In addition, treatment with cefuroxime axetil for either 5 or 10 days is associated with significantly fewer gastrointestinal adverse events, particularly diarrhea and nausea, than is 10-day treatment with amoxicillin-clavulanate.

show abstract

Section: Discussionmentioning

confidence: 99%

Effectiveness of short-course therapy (5 days) with cefuroxime axetil in treatment of secondary bacterial infections of acute bronchitis

Henry

Ruoff

Rhudy

et al. 1995

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…High tissue concentrations of both components may be achieved after either oral or parenteral administration (Munch, Blaser & Siegenthaler, 1981;Weismeier et al, 1989). Good in-vitro anti-staphylococcal activity is reflected in efficacy in vivo, as shown in the experimental model of endocarditis (Cantoni etal., 1989;Franciolli etal., 1991;Fluckigere/a/., 1992;Entenza et al, 1994) as well as clinically (Fleisher, Wilmott & Campos, 1983;Camacho et al, 1992;Powers, 1993;Tassler, 1993;Moreillon, 1994). Good results have been obtained with ampicillin/sulbactam in children with staphylococcal skeletal infections (Aronoffe/ al., 1986;Loffler et al, 1986).…”

Section: Advantages and Disadvantages Of Co-amoxiclav (Or Similar Commentioning

confidence: 99%

Amoxycillin-clavulanate versus methicillin or isoxazolyl penicillins for treatment of Staphylococcus aureus infections

Moreillon

1995

J Antimicrob Chemother

View full text Add to dashboard Cite

“…Antimicrobial agents effective against potentially resistant pathogens must therefore be used for empiric treatment. The most common pathogens identified in studies 4,[8][9][10]14 of patients with acute bacterial sinusitis were S pneumoniae and H influenzae, with S aureus, gram-negative bacilli, and anaerobes identified with varying frequency. ␤-Lactamase-producing bacteria(suchasHinfluenzae)areresistanttopenicillinsalone and susceptible to the amoxicillin-clavulanate combination.…”

Section: Commentmentioning

confidence: 99%

A Combination of Amoxicillin and Clavulanate Every 12 Hours vs Every 8 Hours for Treatment of Acute Bacterial Maxillary Sinusitis

Seggev

Enrique²,

Brandon³

et al. 1998

Arch Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

Clinical comparison of cefuroxime axetil and amoxicillin/clavulanate in the treatment of patients with acute bacterial maxillary sinusitis

Cited by 58 publications

References 11 publications

Effectiveness of short-course therapy (5 days) with cefuroxime axetil in treatment of secondary bacterial infections of acute bronchitis

Effectiveness of short-course therapy (5 days) with cefuroxime axetil in treatment of secondary bacterial infections of acute bronchitis

Amoxycillin-clavulanate versus methicillin or isoxazolyl penicillins for treatment of Staphylococcus aureus infections

A Combination of Amoxicillin and Clavulanate Every 12 Hours vs Every 8 Hours for Treatment of Acute Bacterial Maxillary Sinusitis

Contact Info

Product

Resources

About