A Combination of Amoxicillin and Clavulanate Every 12 Hours vs Every 8 Hours for Treatment of Acute Bacterial Maxillary Sinusitis

Seggev, Joram S.; Enrique, Ronel R.; Brandon, Milan L.; Larsen, L. Scott; Tuyl, Ronald A. Van; Rowinski, Carolyn

doi:10.1001/archotol.124.8.921

Cited by 12 publications

(7 citation statements)

References 12 publications

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“…The low efficacy of amoxicillin/ potassium clavulanate found in these studies could possibly be thus in part due to random error, and not an accurate measure of the efficacy of the antibiotic used. The efficacy of amoxicillin/potassium clavulanate found in the other 5 studies ranged from 74.5% -93% (11,17,21,23,25) , suggesting that the true efficacy of amoxicillin/potassium clavulanate is probably closer to 80%. In general, between studies, we note that there is a big variation of efficacy and side effects even just within the same drug, and in the future we need more standardized studies to be able to have better evidence on the efficacy and side effects of various drugs used in the treatment of ARS.…”

Section: Discussionmentioning

confidence: 91%

“…For amoxicillin/potassium clavulanate, the efficacy ranges from 50% to 93% (11,21,(23)(24)(25)34) . One reason for the large range could be due to the 2 studies by Wald et al (24,34) , which had small sample sizes of 28 patients in each study.…”

Section: Discussionmentioning

confidence: 99%

“…All studies (11,17,21,(23)(24)(25) used a dosing regimen of 500/125 mg thrice a day for 10 to 14 days. Most studies reported quite a high incidence of minor adverse effects, with 3 studies reporting a side effect rate of more than 40% (21,23,24) .…”

Section: Amoxicillin/potassium Clavulanate (Figure 3)mentioning

confidence: 99%

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Efficacy and side effects of antibiotics in the treatment of acute rhinosinusitis: a systematic review

Sng¹,

Wang²

2015

Rhin

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Background: Acute rhinosinusitis (ARS) is one of the most common diagnoses for which an antibiotic is prescribed. Although the usage of antibiotics in the treatment of mild, moderate or uncomplicated ARS is not recommended by most international guidelines, overuse of antibiotics is still an alarming problem among patients and healthcare practitioners. We thus sought to review the evidence available through a systematic review of the existing literature on antibiotic usage in ARS.Methodology: A search of the PubMed database was conducted for studies on antibiotic and placebo usage in the treatment of ARS.Results: A total of 31 random control trials (RCT) reporting the clinical efficacy of treating ARS and side effects of using cefuroxime axetil, telithromycin, amoxicillin/potassium clavulanate, levofloxacin, moxifloxacin and clarithromycin were included in the review.Among them, 9 studies were performed double-blinded with placebo controls. The results showed that while antibiotics are more efficacious than placebos in the treatment of ARS, the risks of potential side effects need to be weighed against the potential benefit that antibiotics give to the patient. This is especially pertinent as usage of the placebo has shown to be almost as efficacious as using the antibiotic therapy, and also much safer. Conclusion:The usage of antibiotics in ARS is widespread and there seems to be only slight added benefit in the usage of antibiotics over placebo in the treatment of ARS. Hence, larger scale studies should be done in the future to confirm the results of these studies.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Efficacy and side effects of antibiotics in the treatment of acute rhinosinusitis: a systematic review

Sng¹,

Wang²

2015

Rhin

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“…Five clinical trials (Table 1) in adults [7][8][9][10][11], involving over 2100 patients, compared the bacteriological and clinical efficacy of the BD and TID doses of amoxicillin/clavulanate. No significant difference was seen between the BD and TID regimens in the bacteriological and clinical success rates in any of the infections.…”

Section: Clinical Trials In Adultsmentioning

confidence: 99%

Development of a twice daily dosing regimen of amoxicillin/clavulanate

Bax¹

2007

International Journal of Antimicrobial Agents

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“…The efficacy of amoxicillin/potassium clavulanate ranged from 50% to 93%. All studies (11,17,21,(23)(24)(25) used a dosing regimen of 500/125 mg thrice a day for 10 to 14 days. Most studies reported quite a high incidence of minor adverse effects, with 3 studies reporting a side effect rate of more than 40% (21,23,24) .…”

Section: Cefuroxime Axetil (Figure 1)mentioning

confidence: 99%

Efficacy and side effects of antibiotics in the treatment of acute rhinosinusitis: a systematic review

Sng¹,

Wang²

2015

Rhin

View full text Add to dashboard Cite

Background: Acute rhinosinusitis (ARS) is one of the most common diagnoses for which an antibiotic is prescribed. Although the usage of antibiotics in the treatment of mild, moderate or uncomplicated ARS is not recommended by most international guidelines, overuse of antibiotics is still an alarming problem among patients and healthcare practitioners. We thus sought to review the evidence available through a systematic review of the existing literature on antibiotic usage in ARS. Methodology: A search of the PubMed database was conducted for studies on antibiotic and placebo usage in the treatment of ARS. Results: A total of 31 random control trials (RCT) reporting the clinical efficacy of treating ARS and side effects of using cefuroxime axetil, telithromycin, amoxicillin/potassium clavulanate, levofloxacin, moxifloxacin and clarithromycin were included in the review. Among them, 9 studies were performed double-blinded with placebo controls. The results showed that while antibiotics are more efficacious than placebos in the treatment of ARS, the risks of potential side effects need to be weighed against the potential benefit that antibiotics give to the patient. This is especially pertinent as usage of the placebo has shown to be almost as efficacious as using the antibiotic therapy, and also much safer. Conclusion: The usage of antibiotics in ARS is widespread and there seems to be only slight added benefit in the usage of antibiotics over placebo in the treatment of ARS. Hence, larger scale studies should be done in the future to confirm the results of these studies.

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A Combination of Amoxicillin and Clavulanate Every 12 Hours vs Every 8 Hours for Treatment of Acute Bacterial Maxillary Sinusitis

Abstract: Amoxicillin and clavulanate given every 12 hours is as effective and as safe as administration every 8 hours for the treatment of acute bacterial maxillary sinusitis.

Cited by 12 publications

References 12 publications

Efficacy and side effects of antibiotics in the treatment of acute rhinosinusitis: a systematic review

Efficacy and side effects of antibiotics in the treatment of acute rhinosinusitis: a systematic review

Development of a twice daily dosing regimen of amoxicillin/clavulanate

Efficacy and side effects of antibiotics in the treatment of acute rhinosinusitis: a systematic review

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