Clinical characteristics of patients with a periorbital mass after autologous fat injection for facial augmentation and short-term outcomes of steroid treatment

Lee, Saem; Lee, Jung Hye; Choi, Hye Sun

doi:10.1016/j.bjps.2015.07.002

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…In addition to the common complications of hematoma, chronic edema, uneven filling at the injection site, and fat necrosis after transplantation, 2 there have been reports of unusual eye complications such as loss of vision resulting from embolization. 3 Sa et al 4 reported nine cases of lipogranuloma of the eyelid after facial injection of autologous fat in 2011; this was followed in 2015 by a report on 50 cases by Lee et al 5 and another on 27 cases in 2016 by Park and Kim. 6 All these reports were from Korea, with no such reports from China until 2017, when a plastic surgeon reported eight cases.…”

Section: Introductionmentioning

confidence: 98%

Periorbital lipogranuloma after facial injection of autologous fat: A retrospective study of 18 cases

Yu¹,

Yan

Xiao

et al. 2020

European Journal of Ophthalmology

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Objective: To investigate the clinical features of patients who develop periorbital lipogranuloma after injection of autologous fat. Methods: This retrospective case series included 18 patients who developed a periorbital mass or swelling after undergoing injection of autologous fat for facial augmentation. The patients’ medical records were reviewed for clinical history, radiologic findings, and treatment outcomes. Results: All patients were women aged 24 to 50 years (mean, 31.6 years). Five patients (27.8%) involved both orbits. Presenting eye symptoms were a palpable mass (61.1%), eyelid swelling (44.4%), and ptosis (16.7%). The interval between the final injection and onset of eye symptoms ranged from 1 to 36 months (mean, 11.5 months). Thirteen patients underwent radiologic imaging. Fifteen patients received only one injection of autologous fat and three received two injections with the cryopreserved fat used in the second injection. Surgical excision was performed in 12 patients to remove the mass and identify the pathologic abnormalities. No recurrence was found during 1 year of follow-up. Two of the six patients who had refused treatment showed spontaneous resolution at the 6-month visit. Conclusion: Periorbital lipogranuloma after facial injection of autologous fat should be considered as a specific orbital disease entity for which MRI is an effective examination method. Surgery is warranted for this condition when conservative treatment is ineffective.

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Section: Introductionmentioning

confidence: 98%

Periorbital lipogranuloma after facial injection of autologous fat: A retrospective study of 18 cases

Yu¹,

Yan

Xiao

et al. 2020

European Journal of Ophthalmology

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“…However, several case reports and case series of granulomatous reactions to fat transfer in the face have been reported. Two of the largest retrospective case series, describing lipogranulomas in the eyelid, cheek, and forehead, were published by Seo and Sa 9 and Lee et al 10 …”

Section: Discussionmentioning

confidence: 99%

“…Steroids were found to be 70% effective (21 patients), surgery was 100% effective (2 patients), and observation was 50% effective (4 patients). Lee et al 10 found oral steroids to be 75% effective (41 patients), but 2 patients went on to require surgery. The authors of this article noted that 78% of their patients had lipogranulomas upon second injection with cryopreserved fat, indicating cryopreserved fat is a risk factor for granuloma formation 10 …”

Section: Discussionmentioning

confidence: 99%

Granulomatous reaction to autologous gluteal fat transfer

2019

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“…Accordingly, it has become increasingly common to utilize fat that has been cryopreserved after the initial fresh fat graft [4]. However, the fat that is cryopreserved after grafting is retained as dead and fibrous tissue, which may be associated with an elevated risk of clinical complications, such as oil cysts [5][6][7].…”

Section: Archives Of Craniofacial Surgerymentioning

confidence: 99%

Comparisons between fresh and cryopreserved fat injections in facial lipofilling

Yang

Kang

2020

Arch Craniofac Surg

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Background: Autologous fat is considered an ideal filler material, and the use of cryopreserved fat grafts is promising in terms of flexibility and efficiency. Therefore, cryopreserved fat grafts have become more common in recent years; however, their complications require further consideration. Methods: We evaluated 53 patients who underwent facial lipofilling at our institution to confirm the clinical usefulness and safety of cryopreserved fat. Fresh fat injections with or without cryopreserved fat were administered. At one or more sites, 22 patients had a single fresh fat injection, four patients had two or more fresh fat injections, 16 patients had one fresh fat injection followed by one cryopreserved fat injection, six patients had one fresh fat injection followed by two cryopreserved fat injections, and five patients had two fresh fat injections and one or more cryopreserved fat injections. Results: In total, 281 sets of injection procedures were performed at various sites, of which 170 involved one fresh fat injection, 89 involved one fresh fat injection and one cryopreserved fat injection, and 11 involved one fresh fat injection and two cryopreserved fat injections. One patient experienced self-resolving inflammation as a complication after the second injection in the right cheek. No statistically significant differences were found between the fresh and cryopreserved fat injections. Conclusion: We suggest that cryopreserved fat is a useful and safe resource for multiple fat injections, with advantages including aseptic fat handling and the delicacy of the technique.

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Clinical characteristics of patients with a periorbital mass after autologous fat injection for facial augmentation and short-term outcomes of steroid treatment

Cited by 7 publications

References 19 publications

Periorbital lipogranuloma after facial injection of autologous fat: A retrospective study of 18 cases

Periorbital lipogranuloma after facial injection of autologous fat: A retrospective study of 18 cases

Granulomatous reaction to autologous gluteal fat transfer

Comparisons between fresh and cryopreserved fat injections in facial lipofilling

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