Clinical characteristics of language regression in children

Abstract

The spectrum of language regression in childhood is incompletely understood. To describe the features of this disorder more fully, we reviewed the records of 196 consecutive children (143 males and 53 females) with language regression or perceived plateau evaluated between 1988 and 1994 by a child neurologist. Mean age at regression was 21.2 months and the mean interval to referral was 34.8 months. A trigger for the regression was identified in 74 of the children (38%) and was associated with a more rapid regression. Mean age at follow-up was 64 months (SD 55). Seventy per cent of the children became nonverbal, and 75% were cognitively impaired. Language regression was associated with a more global autistic regression in 93% of children. There was a history of seizures in 15% of the children. Some recovery occurred in 61% but only one child recovered fully. Improvement was more likely in the 49% who were entirely developmentally normal before the regression. We conclude that language regression in childhood is a serious disorder with significant long-term morbidity.

Distúrbios da aquisição da linguagem e da aprendizagem

“…Other symptoms, which are different from those observed in children with speech delay, are nonverbal communication disorders, stereotyped and persistent behaviors, restricted and/or unusual interests and impaired social interaction. 23 Our conclusion is that language regression in children is a severe disorder with significant longterm comorbidities. 24 Intervention in children with speech disorders Speech and language development may be appropriate or not, depending on chronological age.…”

Landau kleffner syndrome, electrical status epilepticus in sleep and autistic regression: an overview of literature / Landau kleffner sendromu, uykuda elektriksel status epileptikus ve otistik regresyon: Literatüre bir bakış

“…Studies showed that 30% of the children with AR have clinical seizures (6,100,111). Interestingly, seizures in AR are more likely to occur in children who regress in language after age 3 (1,112,113).…”

“…Language regression can occur in children with previously normal language development or may be in the form of a deterioration of the previously abnormal or delayed language skills (1,2).…”

Emerging Roles for Ubiquitin and Protein Degradation in Neuronal Function

“…Although both disorders share similar disease manifestations that are apparent postnatally, the timeline of their observable pathophysiology is intriguingly different. Children born with RTT have an initial 12-to 18-month period of normal development followed by intellectual regression (Wilson et al, 2003), whereas patients with AS have no observable window of normal development (Clayton-Smith, 1993).…”