Clinical Characteristics of Infections Caused by Streptococcus Anginosus Group

Abstract

This study aimed to investigate the clinical characteristics, distribution of different strains and risk factors of patients infected with Streptococcus anginosus group (SAG). In the population of 463 patients, the male-to-female ratio was 1.95:1, and the patient age ranged from 6 months to 103 years. There were 49 children (10.58%), 311 young and middle-aged adults (67.17%), and 103 elderly adults (22.25%). Approximately 45.4% had underlying conditions, which were mostly malignant tumors and diabetes. Of the 463 specimens, 254 were S. anginosus (54.86%), 173 were S. constellatus (37.37%), and 36 were S. intermedius (7.77%). According to the age distribution, the incidence peaked in the 35–54 year age group. Different sites of infection had statistically significant differences regarding the constituent ratios of these three species. Different age groups also exhibited statistically significant differences in constituent ratios of the pathogenic organisms, as well as organ infections. In our population, 269 were clinically cured, 184 reported satisfactory improvement, and 10 died. SAG, as an opportunistic pathogen, can induce pyogenic infections in patients of all ages and shows no significant gender predilection in any age group. The three pathogenic organisms had differences with respect to patient age and infections of body sites.

Clinical Microbiology Perspective of Empyema caused by Streptococcus constellatus in Malignancy Patient: A Case Report

“…Empyema is a serious condition that requires treatment. 2,9,10 In this case, empyema in the patient happened as a complicated of PPE-confirmed on chest…”

“…The incidence rate has reportedly increased continuously in the past two decades. 2 They are associated with abdominal, central nervous system, and pleuropulmonary infections. 1,3 SC empyema is a clinical entity that is described in the scientific literature in very few studies and with few patients, especially in Indonesia.…”

“…The prevalence of pulmonary infection was higher in patients aged 55 years old and above. 2 However, a case in a child was reported in 2020. 4 The preliminary results of this study found 6 (1.14%) of 524 total pleural samples in 2015-2020 were SC.…”

An Unusual Case of Streptococcus anginosus Endocarditis in a Healthy Host With Bicuspid Aortic Valve

“…SAG, including S. anginosus, S. constellatus, and S. intermedius, are gram-positive, catalase-negative cocci and nonmotile facultative anaerobes that have typically small colonies (≤0.5 mm of diameter) [1]. They can exhibit different hemolysis patterns on sheep blood agar and displace different Lancefield antigens; therefore, identification of the group could be challenging [3].…”

“…Streptococcus anginosus group (SAG), formally known as Streptococcal milleri group, consists of S. anginosus, S. constellatus, and S. intermedius. It was first isolated by Guthof in 1956 from dental abscesses [1]. They are frequently found in different parts of the human tissues and are considered harmless normal flora.…”