Clinical characteristics and spatial distribution of Visceral leishmaniasis in children in São Paulo state: an emerging focus of Visceral leishmaniasis in Brazil

Spir, Patrícia Rodrigues Naufal; Prestes-Carneiro, Luiz Euribel; Fonseca, Elivelton Silva; Dayse, Aline; Giuffrida, Rogério; D’Andrea, Lourdes Aparecida Zampieri

doi:10.1080/20477724.2017.1289666

Cited by 12 publications

(18 citation statements)

References 32 publications

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“…Prior studies have presented data regarding the epidemiology of VL, however the analyses were performed based on municipality 9,10 or state 11,12 and based on hospital data 13,14 . One study examined the mortality of VL in Brazil 3 with another focused on the prediction of VL in Brazil 15 .…”

Section: Visceral Leishmaniasis (Vl) Is Classified As a Neglectedmentioning

confidence: 99%

Changes in the epidemiology of visceral leishmaniasis in Brazil from 2001 to 2014

Reis

Balieiro

Fonseca

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Visceral leishmaniasis (VL) is a neglected disease, with territorial expansion and regional differences in Brazil that require explanation. This study aimed to describe changes in the epidemiology of VL in Brazil from 2001 to 2014. Methods: The incidence rates, sociodemographic and clinical data, and case evolution were subgrouped from 2001 to 2006 and from 2007 to 2014 and presented descriptively. Spatial distribution of disease incidence rates and changes in the spatial and temporal pattern were examined. Results: In total, 47,859 VL cases were reported in Brazil between 2001 and 2014, with predominance in the Northeast macroregion (55%), though the incidence rate in this region declined between the two study periods. The State of Tocantins had the highest crude rate (26.2/100,000 inhabitants), which was responsible for VL increasing in the North macroregion. VL predominated in the urban zone (70%), in children under 4 years (34%); however, an increase in the incidence of VL in adults older than 40 years was identified, with 12.3% and 31% in the first and second period, respectively. The mapping of crude rates and autochthonous canine cases showed territorial expansion. The temporal distribution of VL was consistent in Brazil in general, with no pattern observed, but regional differences were found. Conclusions: The incidence of VL is increasing in Brazil. In addition to the State of Tocantins, which had the highest rate, new outbreaks of VL have occurred in the South macroregion of Brazil with small decreases identified in the incidence rate in the Northeast.

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Section: Visceral Leishmaniasis (Vl) Is Classified As a Neglectedmentioning

confidence: 99%

Changes in the epidemiology of visceral leishmaniasis in Brazil from 2001 to 2014

Reis

Balieiro

Fonseca

et al. 2017

Rev. Soc. Bras. Med. Trop.

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“…Acontece que a distribuição do Lu. longipalpis se expande um pouco mais a leste, em direção a Piracicaba e Campinas, o que pode caracterizar no futuro um novo eixo de transmissão humana: prova disso é que a transmissão canina ocorre na região (DONALISIO et al, 2017 transmissão humana sugerem que o problema da LV, sobretudo em cães, venha sendo subestimado nessa região (NAUFAL SPIR et al, 2017;FONSECA et al, 2014;D'ANDREA et al, 2015).…”

Section: Discussionunclassified

“…No estado de São Paulo, em tese, foi registrado o primeiro caso humano de LV em 1999, em Araçatuba. Desde então o vetor está cada vez mais adaptado às áreas urbanas e o estado apresenta atualmente um processo de difusão bem peculiar em direção à fronteira de expansão-oeste (NAUFAL SPIR et al, 2017). O presente trabalho pretende desenvolver uma abordagem geográfica sobre a Leishmaniose Visceral e o vetor Lu.…”

Section: Introductionunclassified

Influência De Variáveis Climáticas E Ambientais Na Distribuição Potencial Do Lutzomyia Longipalpis (Psychodidae: Phlebotominae) No Estado De São Paulo, Brasil

Fonseca

Rodgers²,

Casagrande³

et al. 2019

Hygeia

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Leishmaniose Visceral é uma doença transmitida pelo flebótomo, numa complexa interação com a entidade nosogeográfica. Este trabalho pretende desenvolver uma abordagem geográfica sobre a Leishmaniose Visceral no estado de São Paulo, com o apoio da Modelagem do Nicho Ecológico. O objetivo é correlacionar a distribuição espacial do vetor Lutzomyia longipalpis com variáveis climáticas e ambientais e comparar a distribuição dos casos humanos com o mapa no modelo final da Máxima Entropia (MaxEnt). Foram levantados dados de ocorrência do Lu. longipalpis de 1997 a 2016, por municípios paulistas. Também foram levantados dados ambientais bioclimáticos (BIOCLIM), com resolução espacial de 1km. O vetor Lu. longipalpis foi relatado em 166 municípios desde 1997, sendo a maioria no oeste do estado. No estado, algumas variáveis foram correlacionadas com a distribuição do vetor: Temperatura de Superfície, Distribuição da população, oscilações de temperatura dia-noite (4%), temperatura máxima no mês mais quente (16,1%), além de precipitação no mês mais seco (22,7%), sazonalidade da precipitação (16.7%), Precipitação no trimestre mais úmido (21.8%), precipitação no trimestre mais seco (10.3%) e precipitação no trimestre mais frio (8,3%). Os dados indicam claramente uma probabilidade de expansão do centro do estado em direção a Campinas e Piracicaba. Com relação ao primeiro eixo de expansão no estado, do centro para o oeste, sugere-se trabalho com os assentamentos, que podem ser uma fonte de um caso específico de expansão da LV, o "novo rural", fechando a hipótese rural-urbano-novo rural. tese rural-urbano-novo rural.

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“…These municipalities comprise the Regional Health Assistance Network11 (RRAS11), located in Presidente Prudente’s mesoregion. In this region, from 2006, when the first human case was reported in Dracena, a city with high transmission rates, to 2017, 18 of the 45 municipalities reported 492 human cases and 27 deaths, a lethality rate of 5.5% [4, 5]. The vector of VL, Lutzomyia longipalpis was found in 34 municipalities and canine VL was found in 28 municipalities [5].…”

Section: Introductionmentioning

confidence: 99%

“…VL is a long-term febrile disease and the clinical signs are non-specific and characterized by fever, paleness, weight loss, increased abdominal volume, hepatosplenomegaly, and edema. In new endemic areas, because of the non-specific signs and symptoms, VL can be misdiagnosed with delay in treatment, increasing the severity of the disease [4]. There are few studies on patients with these characteristics in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Unusual manifestations of visceral leishmaniasis in children: a case series and its spatial dispersion in the western region of São Paulo state, Brazil

et al. 2019

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BackgroundVisceral leishmaniasis (VL) is becoming endemic in São Paulo state, in the southeastern region of Brazil. Unusual manifestations with non-specific signs and symptoms may make diagnosis difficult and delay treatment, increasing the risk of severity and death, particularly in new endemic areas. There are few studies on patients with these characteristics in Brazil. We describe a case series of unusual manifestations of VL in children and its spatial dispersion in the western region of São Paulo state.Cases presentationFrom 2009 to 2014, five clinical cases involving children treated in the Regional Hospital of Presidente Prudente (RH) were selected. Two patients had multiple relapses requiring liposomal amphotericin B; one patient had VL-cytomegalovirus-dengue co-infection and liver injury; one patient was diagnosed with X-linked agammaglobulinemia, a primary immunodeficiency; and one patient was diagnosed with VL-human immunodeficiency virus/acquired immunodeficiency syndrome (VL-HIV/AIDS) co-infection. Primary or secondary immunodeficiencies were found in four children, and associated viral infections were found in three children. Three patients were referred from other hospitals to RH. With regard to the geographic spread of VL, more cases were found in the northern area, in the epicenter of the infection where the first cases were registered, flowing south; a spatial-temporal occurrence was found.ConclusionsPrimary and secondary immunodeficiencies and viral co-infectious should be considered among unusual manifestations of VL, especially in those with multiple relapses. Spatial-temporal occurrence was found. Thus, integrated actions and effective monitoring of the disease are needed to complement curative practices to stem the tide of the epidemic.

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Clinical characteristics and spatial distribution of Visceral leishmaniasis in children in São Paulo state: an emerging focus of Visceral leishmaniasis in Brazil

Cited by 12 publications

References 32 publications

Changes in the epidemiology of visceral leishmaniasis in Brazil from 2001 to 2014

Changes in the epidemiology of visceral leishmaniasis in Brazil from 2001 to 2014

Influência De Variáveis Climáticas E Ambientais Na Distribuição Potencial Do Lutzomyia Longipalpis (Psychodidae: Phlebotominae) No Estado De São Paulo, Brasil

Unusual manifestations of visceral leishmaniasis in children: a case series and its spatial dispersion in the western region of São Paulo state, Brazil

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