Clinical, Biochemical, and Pharmacological Role of Zinc

Prasad, A S

doi:10.1146/annurev.pa.19.040179.002141

Cited by 245 publications

(107 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…'^ This recommendation is also based on the finding of high hepatic copper concentrations in canine hepatopathies associated with chole~tasis.~-l~~~' Zinc therapy is not associated with significant adverse effects except at very high doses when iron deficiency and hemolytic anemia are possible. 89 …”

Section: Zincmentioning

confidence: 99%

Pathophysiology and Pharmacologic Modulation of Hepatic Fibrosis

Leveille

Arias

1993

Veterinary Internal Medicne

View full text Add to dashboard Cite

Most chronic liver disorders are accompanied morphologically by the deposition of fibrous tissue within the hepatic parenchyma. This fibrotic tissue compromises hepatic function and contributes significantly to hepatic failure. Fibrosis is a dynamic process associated with the continual deposition and resorption of connective tissue. Therapeutic strategies are emerging whereby this dynamic process can be modulated. Since collagen is the major component of the extracellular matrix deposited in hepatic fibrosis, most anti‐fibrotic therapies have been directed toward the control of collagen metabolism. After collagen genes are transcribed and translated into precursor procollagen proteins, a number of post‐translational modifications that ensure the deposition of structurally sound collagen within the extracellular matrix occur. A number of drugs can specifically modulate collagen biosynthesis at the transcriptional level or at various post‐translational stages. These anti‐fibrotic drugs include corticosteroids, azathioprine, penicillamine, colchicine, zinc, prostaglandins, cyclosporine, and interferons. The pharmacologic action of these drugs and the clinical role in veterinary and human fibrotic hepatopathies will be discussed.

show abstract

Section: Zincmentioning

confidence: 99%

Pathophysiology and Pharmacologic Modulation of Hepatic Fibrosis

Leveille

Arias

1993

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…Zinc in the plasma is predominantly bound to albumin, but other proteins, e.g. a,-macroglobulin, transferrin, prealbumin, also bind significant amounts of zinc [31,321. In addition to the proteinbound fraction, a small proportion of zinc exists in the plasma as an ultrafiltrable fraction, mostly bound to amino acids, but a smaller fraction being present in an ionic form [32].…”

Section: Zinc and Living Systemsmentioning

confidence: 99%

“…Zinc is an essential element for the maintenance of normal T-cells and other immune functions in vivo [31,42441. It is necessary for T-cell differentiation and maturation [45], and lymphocytes are one of the few types of cell to be activated by zinc [44], where zinc transferrin receptor sites are present on human lymphocytes [46].…”

Section: Zinc and The Immune Systemmentioning

confidence: 99%

The role of zinc in acquired immunodeficiency syndrome

Odeh

1992

Journal of Internal Medicine

View full text Add to dashboard Cite

“…Zinc is also used to prevent the development of several deficiency symptoms include parakeratosis, hypogeusia, anorexia, dysosmia, geophagia, hypogonadism, growth retardation, etc. [5][6][7]. Recently, it has been reported that zinc had increased the leukocyte count and phagocytic index, which potentiate the immunomodulatory effect along with Glycyrrhiza glabra [8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Physicochemical, Structural, Thermal, and Behavioral Properties of the Energy of Consciousness Healing Treated Zinc Chloride

Trivedi¹

2017

BIO

View full text Add to dashboard Cite

Zinc chloride is a source of zinc used in various pharmaceutical/nutraceutical formulations. The objective of the current study was to investigate the impact of The Trivedi Effect ® -Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physical, structural, thermal, and behavioral properties of zinc chloride using PXRD, PSD, FT-IR, UVvis, and DSC analysis. Zinc chloride was divided into two parts -one part was control, while another part was treated with The Trivedi Effect ® remotely by twenty renowned Biofield Energy Healers and defined as The Trivedi Effect ® Treated sample. A significant alteration of the crystallite size and relative intensities of the PXRD peaks was observed in The Trivedi Effect ® treated sample compared with the control sample. The average crystallite size of the treated sample was significantly increased by 23.18% compared with the control sample. The particle size values at d 10 , d 50 , and d 90 values were significantly decreased by 3.70%, 4.13%, and 6.13%, respectively in the treated sample compared with the control sample. Therefore, the surface area of the treated sample was increased by 4.21% compared with the control sample. The FT-IR spectroscopic analysis revealed that Zn-Cl stretching in the control sample was found at 512 cm -1 , whereas it was significantly shifted upward to 520 cm -1 in the treated sample. The UV-vis analysis exhibited that wavelength of the maximum absorbance (λ max ) of the control and treated samples were at 197.6 nm and 197.1 nm, respectively. The DSC analysis exhibited that the melting temperature was decreased by 0.22%, while decomposition temperature was increased by 2.56% in the treated sample compared to the control sample. The latent heat of fusion of the treated sample (320.44 J/g) was significantly decreased by 16.70% compared with the control sample (284.67 J/g). Similarly, the enthalpy of decomposition of the treated sample (952.53 J/g) was significantly increased by 122.61% compared with the control sample (427.90 J/g). Thus, the results indicated that the thermal stability of the treated zinc chloride was improved compared with the control sample. The current study anticipated that The Trivedi Effect ® -Energy of Consciousness Healing Treatment might lead to produce a thermally stable new polymorphic form of zinc chloride, which would be more soluble and bioavailable compared with the untreated compound. Hence, the treated zinc chloride would be very useful to design better nutraceutical/pharmaceutical formulations that might offer better therapeutic response against American Journal of Bioscience and Bioengineering 2017; 5(2): 65-74 66 inflammatory diseases, immunological disorders, aging, stress, cancer, etc.

show abstract

Clinical, Biochemical, and Pharmacological Role of Zinc

Cited by 245 publications

References 0 publications

Pathophysiology and Pharmacologic Modulation of Hepatic Fibrosis

Pathophysiology and Pharmacologic Modulation of Hepatic Fibrosis

The role of zinc in acquired immunodeficiency syndrome

Evaluation of the Physicochemical, Structural, Thermal, and Behavioral Properties of the Energy of Consciousness Healing Treated Zinc Chloride

Contact Info

Product

Resources

About