The role of zinc in acquired immunodeficiency syndrome

Odeh, Majed

doi:10.1111/j.1365-2796.1992.tb00961.x

Cited by 31 publications

(4 citation statements)

References 80 publications

(44 reference statements)

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“…Zn 2+ deficiency has been described for several diseases, including sickle cell anemia, malnutrition, cancer, alcoholism, uremia, and various infections. For PLWH, serum levels of Zn 2+ decreased with disease progression [108][109][110][111][112][113][114][115][116][117] and clinical symptom similarities exist between HIV-1/AIDS and Zn 2+ deficiency [113,114,118]. Further, higher mortality rates occurred in PLWH with low levels of Zn 2+ [119][120][121][122], and Zn 2+ deficiency and increased levels of tumor necrosis factor-α (TNF-α) were found in people with AIDS [123][124][125].…”

Section: Zinc (Zn 2+ )mentioning

confidence: 99%

Role of Divalent Cations in HIV-1 Replication and Pathogenicity

Khan

Chen

Geiger

2020

Viruses

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Divalent cations are essential for life and are fundamentally important coordinators of cellular metabolism, cell growth, host-pathogen interactions, and cell death. Specifically, for human immunodeficiency virus type-1 (HIV-1), divalent cations are required for interactions between viral and host factors that govern HIV-1 replication and pathogenicity. Homeostatic regulation of divalent cations’ levels and actions appear to change as HIV-1 infection progresses and as changes occur between HIV-1 and the host. In people living with HIV-1, dietary supplementation with divalent cations may increase HIV-1 replication, whereas cation chelation may suppress HIV-1 replication and decrease disease progression. Here, we review literature on the roles of zinc (Zn2+), iron (Fe2+), manganese (Mn2+), magnesium (Mg2+), selenium (Se2+), and copper (Cu2+) in HIV-1 replication and pathogenicity, as well as evidence that divalent cation levels and actions may be targeted therapeutically in people living with HIV-1.

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Section: Zinc (Zn 2+ )mentioning

confidence: 99%

Role of Divalent Cations in HIV-1 Replication and Pathogenicity

Khan

Chen

Geiger

2020

Viruses

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“…n Zinc Zinc is important for maintaining an intact immune system. Adequate levels of zinc are necessary for activation of lymphocytes [269][270][271]. Zinc deficiency reduces generation of T cells, depresses humoral and cell-mediated immunity and causes lymphopenia, thymic atrophy, reduced capacity of macrophages to take up and kill parasites, and increased susceptibility to a greater number of infections [272,273].…”

Section: Micronutrients and Hiv Infection | Reviewmentioning

confidence: 99%

Micronutrients and HIV Infection

Campa

Baum²

2010

HIV Ther.

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The immune system requires several essential micronutrients to maintain an effective immune response. HIV infection destroys the immune system and promotes nutritional deficiencies, which further impair immunity. This article reviews the role of several micronutrients (vitamins A, C, E and D, the B vitamins, and minerals, selenium, iron and zinc) that are relevant for maintaining immune function. In addition, the deficiencies of these micronutrients have been associated with faster progression of HIV-1 disease. This review examines the evidence from observational studies of an association between micronutrient status and HIV disease, as well as the effectiveness of micronutrient supplementation on HIV-disease progression, pregnancy outcomes and nutritional status, among others, utilizing randomized clinical trials. Each micronutrient is introduced with a summary of its functions in human physiology, followed by the presentation of studies conducted in HIV-infected patients in relation to this specific micronutrient. Overall findings and recommendations are then summarized.

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“…Bei Zinkmangel besteht offenbar eine verstärkte biologische Wirkung zyto-und histotoxischer Zytokine [12]. Er könnte zur entzündungsbedingten Ulkusbildung beigetragen haben.…”

Section: Diskussionunclassified

Rezidivierende schankriforme Schleimhautulzera bei Plasmozytom mit sekundärem IgA-Mangel

et al. 2001

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A 66 year old patient presented with a nine month history of recurrent oral ulcerations involving the tongue. We diagnosed chancriform pyoderma and a previously not identified multiple myeloma with secondary immunoglobulin deficiency. Clinically and histologically we excluded a necrotizing ulcerative stomatitis as found in individuals with cellular immunodeficiency as in late-stage HIV-infection. On culture only Neisseria catarrhalis was found. Chancriform pyoderma is often associated with local bacterial infections, especially Staphylococcus aureus. The most common sites are the genitalia and periorbital region; involvement of the oral mucosa is uncommon. To the best of our knowledge, this is the fourth reported case with tongue lesions. The multiple myeloma-associated immunoglobulin deficiency might have facilitated the oral manifestations of chancriform pyoderma.

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The role of zinc in acquired immunodeficiency syndrome

Cited by 31 publications

References 80 publications

Role of Divalent Cations in HIV-1 Replication and Pathogenicity

Role of Divalent Cations in HIV-1 Replication and Pathogenicity

Micronutrients and HIV Infection

Rezidivierende schankriforme Schleimhautulzera bei Plasmozytom mit sekundärem IgA-Mangel

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