Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis

Frisbie, David D.; Kawcak, Christopher E.; Werpy, Natasha M.; Park, Richard D.; McIlwraith, C. Wayne

doi:10.2460/ajvr.68.3.290

Cited by 230 publications

(255 citation statements)

References 14 publications

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“…IA injections of IL-1-Ra or transfection of IL-1-Ra gene has been shown to reduce the progression of experimental OA in animal models 9 as well as provide clinical benefits in horses 10 and humans.…”

Section: -8mentioning

confidence: 99%

“…22 Our novel autologous conditioning processing, Arthrokinex TM (ACS), and subsequent standardized protocol, was developed following the success of treatment strategies such as Orthokine and Arthrex that induced IL-1-Ra from whole blood. 10,11 Arthrokinex TM (ACS) offers an interventional orthopedic treatment plan at the molecular level and it incorporates the inhibition of IL-1b through the rapid induction of IL-1-Ra. We have previously demonstrated that our novel formulation produces IL-1-Ra levels that are consistently adequate to block the IA destructive effects of IL-b.…”

Section: -14mentioning

confidence: 99%

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A new treatment for knee osteoarthritis: Clinical evidence for the efficacy of Arthrokinex™ autologous conditioned serum

Barreto

Braun

2017

Journal of Orthopaedics

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Section: -8mentioning

confidence: 99%

Section: -14mentioning

confidence: 99%

A new treatment for knee osteoarthritis: Clinical evidence for the efficacy of Arthrokinex™ autologous conditioned serum

Barreto

Braun

2017

Journal of Orthopaedics

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“…Other recent studies documented the effectiveness of platelet growth factors in prevention of joint degeneration by control of synthesis and decreasing extracellular matrix proteins (24,25). Wu et al in their animal study showed the effectiveness of PRP injections in new cartilage formation (26).…”

Section: Discussionmentioning

confidence: 99%

Platelet-Rich Plasma Injection for Symptomatic Knee Osteoarthritis

et al. 2015

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Background: Platelet-rich plasma (PRP) is plasma of enriched platelets with high concentration of platelet granules and growth factors. The platelet growth factors have a great potential of wound and connective tissue healing used to treat cartilage lesions and retarding the progression of knee osteoarthritis. Objectives: This study was designed to evaluate PRP injection results in knee osteoarthritis. Patients and Methods:This was a case-series study of 39 patients and all of them had three injections of PRP for the involved knee (every two weeks) and they were followed up at two weeks, two months and six months post-injection of PRP. All included patients filled the WOMAC (western Ontario and Mcmaster universities arthritis index) standardized and translated to our national language and culture. We analyzed the collected scores of before initiation of PRP injections, the second week, the second month and the sixth month after injections into the knees. Results: Thirty-nine patients with a mean age of 55.24 ± 9.27 years (ranged 40 to 83) were evaluated in this study. Six patients (15.4%) were male and 33 patients (84.6%) female. There were significant differences in WOMAC score of patients in two months and six months after injection of PRP compared to before injection. Conclusions: PRP had a great clinical improvement in short-term follow-up for early stages of knee osteoarthritis.

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“…Moreira (2013) observou que a aplicação intraarticular de plasma autólogo condicionado em articulações hígidas causou efeito inflamatório leve e transitório nas primeiras 24 horas após aplicação, caracterizado por aumento de PGE 2 . Frisbie et al (2007) avaliaram os efeitos clínicos, bioquímicos e histológicos do ACS em OA induzida após a realização de defeitos osteocondrais na articulação intercárpica em 16 equinos. Após 15 dias da indução da lesão iniciouse um protocolo de exercício e nos dias 14, 21, 28 e 35 foram realizadas aplicações intra-articulares de 6 ml de ACS no grupo tratado e 6 ml de PBS no grupo controle.…”

Section: O Emprego Dos Derivados Sanguíneos Nas Lesões Osteoarticularesunclassified

Uso do soro autólogo condicionado e do plasma rico em plaquetas na terapia ortopédica de equinos

et al. 2014

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ResumoAs lesões musculoesqueléticas que ocorrem durante a prática esportiva em equinos são debilitantes e demandam um longo período de tratamento e reabilitação, para muitas vezes obter-se após o tratamento apenas um tecido cicatricial, predispondo à recidiva. Em busca de terapias mais efetivas e da reparação tecidual de melhor qualidade, tem sido estudada a utilização de derivados sanguíneos, como plasma rico em plaquetas e soro autólogo condicionado. Apesar de ambos serem considerados hemoderivados, o soro autólogo condicionado e o plasma rico em plaquetas são produtos distintos com indicações totalmente diferentes para seu uso. Em lesões tendíneas e ligamentares o plasma rico em plaquetas apresenta resultado promissor em estudos clínicos e experimentais. Nas lesões osteoarticulares estes resultados são obtidos tanto com o soro autólogo condicionado como com o plasma rico em plaquetas. A presente revisão tem como objetivo apresentar estudos clínicos e experimentais (in vivo e in vitro) na espécie equina, que auxiliem na escolha do melhor hemoderivado a ser utilizado frente às diferentes lesões musculoesqueléticas. Palavras-chave: Plasma rico em plaquetas, soro autólogo condicionado, tendão, ligamento, articulação, músculo AbstractMusculoskeletal injuries that occur in horses during sports activities are often disabling and require a long period of treatment and rehabilitation, most resulting in scar tissue, predisposing to recurrence. In search of more effective therapies and tissue regeneration, studies have been carried out with blood derivatives -platelet rich plasma and autologous conditioned serum. In spite of both being bloodderived therapies, platelet rich plasma and autologous conditioned serum are distinct products, with equally distinct indications for their use. Platelet rich plasma shows promising results in ligament and tendon injuries in clinical and experimental trials. This occurs also in osteoarticular lesions with both hemoderivates, autologous conditioned serum and platelet rich plasma. This review aims to present clinical and experimental studies (in vivo and in vitro) in the equine species, as an aid for an appropriate therapeutic choice, when hemoderivates are considered for treatment of musculoskeletal lesions.

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Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis

Cited by 230 publications

References 14 publications

A new treatment for knee osteoarthritis: Clinical evidence for the efficacy of Arthrokinex™ autologous conditioned serum

A new treatment for knee osteoarthritis: Clinical evidence for the efficacy of Arthrokinex™ autologous conditioned serum

Platelet-Rich Plasma Injection for Symptomatic Knee Osteoarthritis

Uso do soro autólogo condicionado e do plasma rico em plaquetas na terapia ortopédica de equinos

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