A new treatment for knee osteoarthritis: Clinical evidence for the efficacy of Arthrokinex™ autologous conditioned serum

Barreto, Angelique; Braun, Timothy R.

doi:10.1016/j.jor.2016.10.008

Cited by 17 publications

(16 citation statements)

References 34 publications

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“…Currently, several commercially available kits are utilised to prepare ACS/APS from whole-blood samples of patients [32,38,43]. In general, both ACS and APS are prepared from autologous peripheral blood, the volume of which can vary between 10 and 60 ml depending on the manufacturer kit [20,37,38].…”

Section: Basic Science Of Acs/aps Production Methodsmentioning

confidence: 99%

“…All the investigational studies of these products have been performed on cohorts of patients with symptomatic knee OA excluding patients with conditions like systemic/inflammatory joint disease and crystalline/ neuropathic arthropathy. It must be noted that whilst some investigators excluded patients who had had surgery on their knee within 3 months [31,38] of the screening visit others have extended this time limit to 6 [22] and 12 months [21]. Furthermore, there is significant variation in the inclusion criteria with respect to patients who have received intraarticular treatments.…”

Section: Factors Influencing the Outcome Of Acs/aps Treatment Patientmentioning

confidence: 99%

“…However, there is no clear agreement in terms of the objective criteria used to assess the severity of knee OA prior to performing these injections in the study patients. A combination of American College of Rheumatology (ACR) criteria [31,38], visual analogue scale (VAS) [38,39], numeric rating scale (NRS) [35], Western Ontario and McMaster Universities osteoarthritis instrument (WOMAC) [21,22,39], including the pain subscale, have been used by the investigators.…”

Section: Factors Influencing the Outcome Of Acs/aps Treatment Patientmentioning

confidence: 99%

“…Considerable variation is noted with the injection regimen for ACS (Table 2). Some investigators [31,37] have used 1 ml whilst others [24,34,35,39] have administered 2 ml of ACS. Furthermore, the number of injections performed is variable ranging between three [37] to six [31,36] over a period of 2-3 weeks.…”

Section: Injection Technique and Regimenmentioning

confidence: 99%

“…Some investigators [31,37] have used 1 ml whilst others [24,34,35,39] have administered 2 ml of ACS. Furthermore, the number of injections performed is variable ranging between three [37] to six [31,36] over a period of 2-3 weeks. In contrast all the studies [20][21][22] with APS used a single injection of 2.5 ml.…”

Section: Injection Technique and Regimenmentioning

confidence: 99%

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Autologous cell-free serum preparations in the management of knee osteoarthritis: what is the current clinical evidence?

Angadi

Macdonald

Atwal

2020

Knee Surg & Relat Res

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Background: There is paucity in the current literature regarding clinical outcomes of autologous cell-free serum preparations. The objective of this paper is to collate the clinical evidence and review the results of intraarticular injections of autologous cell-free serum preparations in the management of knee osteoarthritis (OA). Methods: A comprehensive English literature search was undertaken using the healthcare database website (https://hdas.nice.org.uk/). The PubMed, Medline, CINAHL, Embase and the Cochrane library databases were searched to identify all studies of autologous protein solution/autologous conditioned serum (ACS/APS) in the management of knee OA. We evaluated the reported clinical outcomes with respect to pain, function, morbidity, adverse effects and complications. Results: Fifteen relevant articles were identified in the current literature. Outcomes following injection of ACS/APS have been reported in patients with age range (34-87 years) and unilateral or bilateral knee OA. Seven studies reported improvement in visual analog scale (VAS) whereas the Western Ontario and McMaster Universities osteoarthritis instrument (WOMAC) score improved in nine studies. Considerable variation was noted in the injection technique and duration of post-procedure assessment with only one study reporting long-term follow-up beyond 24 months. Joint swelling and injection-site pain were reported to be the most common complications; only one study reported a case of septic arthritis. However, no evidence is available to clearly identify factors that may predict the outcomes following this procedure. Conclusion: Current data from the clinical studies would suggest that the intraarticular administration of autologous cell-free serum preparations, such as ACS/APS, in patients with knee OA may improve pain and function, with limited morbidity. High-quality clinical trials with stratified patient cohorts, longer follow-up duration and robust reporting of outcome measures are essential to improve the understanding of the indications and clinical effectiveness of these novel products.

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Section: Basic Science Of Acs/aps Production Methodsmentioning

confidence: 99%

Section: Factors Influencing the Outcome Of Acs/aps Treatment Patientmentioning

confidence: 99%

Section: Factors Influencing the Outcome Of Acs/aps Treatment Patientmentioning

confidence: 99%

Section: Injection Technique and Regimenmentioning

confidence: 99%

Section: Injection Technique and Regimenmentioning

confidence: 99%

See 3 more Smart Citations

Autologous cell-free serum preparations in the management of knee osteoarthritis: what is the current clinical evidence?

Angadi

Macdonald

Atwal

2020

Knee Surg & Relat Res

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Intraarticular Injection Prior to Joint Replacement and its Relationship to Prosthetic Joint Infection

Angadi¹,

Bolton²,

Kandhari³

et al. 2021

Infection in Knee Replacement

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Clinical indications for image-guided interventional procedures in the musculoskeletal system: a Delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)—part V, knee

et al. 2021

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Objectives Interventional procedures around the knee are widely adopted for treating different musculoskeletal conditions. A panel of experts from the Ultrasound and Interventional Subcommittees of the European Society of Musculoskeletal Radiology (ESSR) reviewed the existing literature to assess the evidence on image-guided musculoskeletal interventional procedures around the knee, with the goal of highlighting some controversies associated with these procedures, specifically the role of imaging guidance, as well as the efficacy of the medications routinely injected. Methods We report the results of a Delphi-based consensus of 53 experts in musculoskeletal radiology, who reviewed the published literature for evidence on image-guided interventional procedures around the knee to derive a list of pertinent clinical indications. Results A list of 10 statements about clinical indications of image-guided procedures around the knee was created by a Delphi-based consensus. Only two of them had the highest level of evidence; all of them received 100% consensus. Conclusions Ultrasonography guidance is strongly recommended for intra-articular and patellar tendinopathy procedures to ensure the precision and efficacy of these treatments. Prospective randomized studies remain warranted to better understand the role of imaging guidance and assess some of the medications used for interventional procedures around the knee. Key Points • A list of 10 evidence-based statements on clinical indications of image-guided interventional procedures around the knee was produced by an expert panel of the ESSR. • Strong consensus with 100% agreement was obtained for all statements. • Two statements reached the highest level of evidence, allowing us to strongly recommend the use of ultrasonography to guide intra-articular and patellar tendon procedures to ensure higher accuracy and efficacy of these treatments.

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A new treatment for knee osteoarthritis: Clinical evidence for the efficacy of Arthrokinex™ autologous conditioned serum

Cited by 17 publications

References 34 publications

Autologous cell-free serum preparations in the management of knee osteoarthritis: what is the current clinical evidence?

Autologous cell-free serum preparations in the management of knee osteoarthritis: what is the current clinical evidence?

Intraarticular Injection Prior to Joint Replacement and its Relationship to Prosthetic Joint Infection

Clinical indications for image-guided interventional procedures in the musculoskeletal system: a Delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)—part V, knee

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