Clinical behavior of solitary fibrous tumor: a retrospective review of 30 patients

Abstract

SFT can be an aggressive disease and relapses can occur several years from diagnosis. We did not find any clinicopathologic factors that could predict the tumor behavior accurately. Nevertheless, it should be consider that we included different tumor locations and the sample size is small.

Solitary Fibrous Tumor of the Stomach

“…The lesions often appear homogenous on computed tomography and are enhanced after contrast administration. On MRI, SFTs typically display low T1 signal intensity and variable T2 signal intensity, and they enhance intensely after intravenous gadolinium administration 2,3,11. Needle aspiration biopsy for SFTs usually provides inconclusive results.…”

“…Various sites of metastasis have been described in the literature, including lungs, mediastinum, liver, bone, pancreas, kidney, mesentery, and retroperitoneum 9-13. Generally, malignant SFTs have a poor prognosis 11-13. Therefore, it is a matter of urgency to reach a consensus to clarify the malignant propensity of SFTs to diagnose such patients early and institute an effective treatment.…”

Extrameningeal solitary fibrous tumors—surgery alone or surgery plus perioperative radiotherapy: A retrospective study from the global solitary fibrous tumor initiative in collaboration with the Sarcoma Patients EuroNet

“…Solitary fibrous tumor (SFT), formerly known as hemangiopericytoma , is a rare mesenchymal tumor with an incidence of approximately 0.2 per 100,000 population per year 1 . SFTs can arise anywhere in the body, including the central nervous system/meninges, head and neck, thorax/pleura, and soft tissues.…”

“…In particular, malignant SFTs are marked by >4 mitoses per 10 high‐power fields (HPF) 2 . SFTs are seen in patients of all ages but predominantly among those in the fifth and sixth decades of life, presenting as slowly growing masses that cause symptoms because of local compression by the primary tumor and/or because of metastatic sites 1,3‐5 . Imaging features of these tumors are nonspecific, leaving a broad differential diagnosis 6‐10 .…”

“…For these patients, the risk of local relapse is known to be increased. The potential added value of (neo‐)adjuvant RT in combination with surgery, both in the setting of a gross total resection or after less radical surgery for LC and survival, remains unclear 1,5,15‐23 . The outcome for patients after definitive RT, without surgery, has recently been described by our group 24 …”