Solitary Fibrous Tumor of the Stomach

Inayat, Faisal; Hussain, Qulsoom; Shafique, Khurram; Hurairah, Abu; Grossman, Evan

doi:10.14309/crj.2017.35

Cited by 11 publications

(14 citation statements)

References 12 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…48,54 Based on imaging studies and endoscopic evaluation, differential diagnoses of gastric IFP include GIST, leiomyoma, inflammatory pseudotumor, solitary fibrous tumors, spindle cell carcinoid, hemangioendothelioma, schwannomas, hemangiopericytoma, T-cell lymphoma, and pancreatic rests. 48,55 Diagnostic yields of endoscopic biopsy and EUS are low, with only 10% of gastric IFPs diagnosed in the preoperative setting. The diagnosis is thus often established on histopathology following complete resection.…”

Section: Discussionmentioning

confidence: 99%

Gastric Inflammatory Fibroid Polyp: A Rare Cause of Occult Upper Gastrointestinal Bleeding

Inayat

Rahman

Wahab³

et al. 2020

Journal of Investigative Medicine High Impact Case Reports

Self Cite

View full text Add to dashboard Cite

Inflammatory fibroid polyps (IFPs) are rare mesenchymal lesions that can arise throughout the gastrointestinal tract. These tumors represent less than 0.1% of all gastric polypoid lesions and are frequently found incidentally on endoscopic evaluation. While presenting symptoms depend on the location of the tumor, gastric polyps commonly present with epigastric pain and early satiety. We hereby delineate the case of a middle-aged female who presented with chronic iron deficiency anemia and a positive fecal occult blood test. She underwent an upper endoscopy, which revealed an actively oozing umbilicated lesion in the gastric antrum. Endoscopic ultrasound divulged the submucosal origin of the lesion. It was subsequently excised using endoscopic mucosal resection. Pathologic examination of the resected specimen confirmed the diagnosis of gastric IFP. Furthermore, we conducted a systematic literature search of the MEDLINE database centered on gastric IFPs from January 2000 till March 2020. The data on patient demographics, clinical features, endoscopic findings, lesion site and size, and treatment approaches were collected and analyzed. This article illustrates the overarching need for clinicians to be vigilant of gastric IFPs presenting with initial clinical symptoms suggestive of occult upper gastrointestinal bleeding. Prompt diagnosis and management of gastric IFPs carry paramount importance to combat chronic unexplained iron deficiency anemia following occult bleeding in such patients. A concoction of endoscopy, biopsy, and immunohistochemical examination can be employed toward their prompt detection. Although gastric IFPs have conventionally been treated with surgery, endoscopic resection is now emerging as a safe and efficient therapeutic modality.

show abstract

Section: Discussionmentioning

confidence: 99%

Gastric Inflammatory Fibroid Polyp: A Rare Cause of Occult Upper Gastrointestinal Bleeding

Inayat

Rahman

Wahab³

et al. 2020

Journal of Investigative Medicine High Impact Case Reports

Self Cite

View full text Add to dashboard Cite

show abstract

“…6 SFT occurring in the stomach or perigastric location is extremely rare. [2][3][4] The imaging feature of SFT in the abdomen and pelvis is characterized as well-defined hypervascular mass with variable degrees of necrosis, cystic change, or hemorrhage. 7 It is not surprising that the radiologic impression in this case was that of a saccular aneurysm.…”

Section: Discussionmentioning

confidence: 99%

“…1 Perigastric/gastric SFTs are extremely rare with only two surgical pathology case reports and one cytology case report. [2][3][4] Hence, the cytologic diagnosis of SFTs can be challenging due to paucity of literature as well as the overlapping cytological features with other spindle cell neoplasms especially in the perigastric/gastric region. We report a case of SFT presenting as a perigastric mass, diagnosed using endoscopic ultrasound guided fine needle aspiration (EUS-FNA) cytology material.…”

Section: Introductionmentioning

confidence: 99%

Perigastric solitary fibrous tumor (SFT) diagnosed on fine needle aspiration: A case report and review of literature

Ababneh

Policarpio‐Nicolas

2020

Diagnostic Cytopathology

View full text Add to dashboard Cite

Solitary fibrous tumor (SFT) is a mesenchymal tumor initially described in the pleura. When the tumor is located in the pleura and the classic histologic findings are present, the diagnosis of SFT can be straightforward. However, the cytologic diagnosis of perigastric SFT can be challenging due its rarity with only one cytology case report. Another confounding factor is its potential mimicry with other perigastric/gastric mesenchymal tumors. Herein, we report a case of perigastric SFT diagnosed on cytology in conjunction with immunohistochemical stains. The patient is a 79-year-old woman who presented with an enlarging perigastric mass on computerized tomography scan which was highly concerning for a saccular aneurysm. Endoscopic ultrasound (EUS) revealed a 6.6 cm hypoechoic lesion abutting the stomach. An EUSguided fine needle aspiration was performed. The smears showed singly scattered to clusters of bland spindle cells with scant cytoplasm dispersed in a bloody background. The cell block showed similar spindle cells focally supported by a collagenized stroma. Immunohistochemical stains performed on the cell block showed the tumor cells were positive for CD34, BCL2, and STAT6 and negative for CD117, DOG1, CD31, ERG-ENDO, AE1/AE3, S-100, desmin, and synaptophysin, supporting the diagnosis of solitary fibrous tumor.

show abstract

“…In this report, we present a rare case of a SFT of the stomach which was complicated by diagnostic dilemma with gastrointestinal stromal tumor (GIST), highlighting the necessity of including this tumor in the differential for neoplasms of the stomach. There were only six cases reported in the literature with none having features of dedifferentiation and early metastatic spread to liver ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Solitary fibrous tumor of the stomach with high-grade sarcomatous dedifferentiation

Voth

Serio

Gross

et al. 2018

Journal of Surgical Case Reports

View full text Add to dashboard Cite

Solitary fibrous tumors (SFT) are uncommon fibroblastic mesenchymal neoplasms that display a wide range of histologic behaviors. These tumors, which are estimated to account for 2% of all soft tissue neoplasms, typically follow a benign clinical course. However, it is estimated that 10–30% of SFTs are malignant and demonstrate aggressive behavior with local recurrence and metastasis up to several years after surgical resection. We report a case of SFT arising from the stomach, which is an exceptionally rare finding and has been reported only six times in the literature. Our case was complicated by diagnostic dilemma with GIST, highlighting the challenges of diagnosing and characterizing SFTs. Additionally, this tumor was associated with dedifferentiation into undifferentiated pleomorphic sarcoma. To our knowledge, there are no documented cases of a malignant SFT arising from the stomach to demonstrate dedifferentiation into an undifferentiated pleomorphic sarcoma.

show abstract

Solitary Fibrous Tumor of the Stomach

Abstract: Solitary fibrous tumor is a rare mesenchymal neoplasm that usually originates from the pleura, but has been reported in other extrapleural locations. We report a rare case of a solitary fibrous tumor of the stomach, which was successfully treated with endoscopic mucosal resection.

Cited by 11 publications

References 12 publications

Gastric Inflammatory Fibroid Polyp: A Rare Cause of Occult Upper Gastrointestinal Bleeding

Gastric Inflammatory Fibroid Polyp: A Rare Cause of Occult Upper Gastrointestinal Bleeding

Perigastric solitary fibrous tumor (SFT) diagnosed on fine needle aspiration: A case report and review of literature

Solitary fibrous tumor of the stomach with high-grade sarcomatous dedifferentiation

Contact Info

Product

Resources

About