Clinical aspects of the use of lactoferrin in dentistry

Krupińska, A; Bogucki, Zdzisław Artur

doi:10.1016/j.job.2021.02.005

Cited by 16 publications

(8 citation statements)

References 40 publications

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“…Moreover, the effects of hemin availability on the VOCs released by P. gingivalis are clearly stronger compared to the treatment with amoxicillin. This finding supports the reports of potential in using iron-binding compounds, such as lactoferrin, in the treatment of periodontitis [51][52][53][54] .…”

Section: Discussionsupporting

confidence: 91%

Antibiotic treatment and supplemental hemin availability affect the volatile organic compounds produced by P. gingivalis in vitro

Roslund

Uosukainen

Järvik

et al. 2022

Sci Rep

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We have measured the changes in the production of volatile organic compounds (VOCs) by the oral pathogen Porphyromonasgingivalis, when treated in vitro with the antibiotic amoxicillin. We have also measured the VOC production of P.gingivalis grown in the presence and absence of supplemental hemin. Planktonic bacterial cultures were treated with different amounts of amoxicillin in the lag phase of the bacterial growth. Planktonic bacteria were also cultured with and without supplemental hemin in the culture medium. Concentrations of VOCs were measured with proton-transfer-reaction time-of-flight mass spectrometry (PTR-ToF–MS) and further molecular identification was done with gas chromatography–mass spectrometry (GC–MS) using solid phase microextraction (SPME) for sampling. The cell growth of P.gingivalis in the cultures was estimated with optical density measurements at the wavelength of 600 nm (OD600). We found that the production of methanethiol, hydrogen sulfide and several short- to medium-chain fatty acids was decreased with antibiotic treatment using amoxicillin. Compounds found to increase with the antibiotic treatment were butyric acid and indole. In cultures without supplemental hemin, indole and short- to medium-chain fatty acid production was significantly reduced. Acetic acid production was found to increase when supplemental hemin was not available. Our results suggest that the metabolic effects of both antibiotic treatment and supplemental hemin availability are reflected in the VOCs produced by P.gingivalis and could be used as markers for bacterial cell growth and response to threat. Analysis of these volatiles from human samples, such as the exhaled breath, could be used in the future to rapidly monitor response to antibacterial treatment.

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Section: Discussionsupporting

confidence: 91%

Antibiotic treatment and supplemental hemin availability affect the volatile organic compounds produced by P. gingivalis in vitro

Roslund

Uosukainen

Järvik

et al. 2022

Sci Rep

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“…It exhibits broad-spectrum antimicrobial properties against bacteria, viruses, and fungi [ 226 ]. Its bio preservative potential against Salmonella enterica and Escherichia coli O157:H7 as two common dairy pathogens was examined, and it showed a considerable reduction in their growth with only lactoferrin concentrations at or above 112.5 mg/mL in the milk [ 227 ].…”

Section: Active Biodegradable Packaging Filmsmentioning

confidence: 99%

Advancements in Biodegradable Active Films for Food Packaging: Effects of Nano/Microcapsule Incorporation

Baghi

Gharsallaoui

Dumas

et al. 2022

Foods

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Food packaging plays a fundamental role in the modern food industry as a main process to preserve the quality of food products from manufacture to consumption. New food packaging technologies are being developed that are formulated with natural compounds by substituting synthetic/chemical antimicrobial and antioxidant agents to fulfill consumers’ expectations for healthy food. The strategy of incorporating natural antimicrobial compounds into food packaging structures is a recent and promising technology to reach this goal. Concepts such as “biodegradable packaging”, “active packaging”, and “bioactive packaging” currently guide the research and development of food packaging. However, the use of natural compounds faces some challenges, including weak stability and sensitivity to processing and storage conditions. The nano/microencapsulation of these bioactive compounds enhances their stability and controls their release. In addition, biodegradable packaging materials are gaining great attention in the face of ever-growing environmental concerns about plastic pollution. They are a sustainable, environmentally friendly, and cost-effective alternative to conventional plastic packaging materials. Ultimately, a combined formulation of nano/microencapsulated antimicrobial and antioxidant natural molecules, incorporated into a biodegradable food packaging system, offers many benefits by preventing food spoilage, extending the shelf life of food, reducing plastic and food waste, and preserving the freshness and quality of food. The main objective of this review is to illustrate the latest advances in the principal biodegradable materials used in the development of active antimicrobial and antioxidant packaging systems, as well as the most common nano/microencapsulated active natural agents incorporated into these food-packaging materials.

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“…Binding iron leads to a confirmation-change from apolactoferrin to hololactoferrin [ 26 ]. Due to its iron-binding and RNase properties, lactoferrin shows antibacterial, antifungal, and antiviral properties [ 22 , 23 , 27 ]. Natural saliva contains approximately 8 µg mL −1 lactoferrin, and it can also be found in breast milk and tear fluid [ 28 ].…”

Section: Overview On Adjunct Ingredients Used In Hydroxyapatite-based...mentioning

confidence: 99%

“…An in situ/in vitro study by Jager et al showed erosion-protective properties by using toothpaste with proteins (e.g., lactoferrin) [ 44 ]. For more information on lactoferrin in oral care, see reviews [ 27 , 28 ].…”

Section: Overview On Adjunct Ingredients Used In Hydroxyapatite-based...mentioning

confidence: 99%

Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products

2022

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Hydroxyapatite, Ca5(PO4)3(OH), is a biomimetic active ingredient, which is used in commercial oral care products such as toothpastes and mouthwashes worldwide. Clinical studies (in vivo) as well as in situ and in vitro studies have shown the preventive effects of hydroxyapatite in various field of oral care. In some products, hydroxyapatite is combined with other active ingredients, to achieve an additional antibacterial effect or to promote gum health. This review analyzes the efficacy of six selected natural and nature-inspired ingredients that are commonly used together with hydroxyapatite. These additional actives are either antibacterial (lactoferrin, xylitol, and zinc) or promote gum health (allantoin, bisabolol, and hyaluronic acid). A systematic literature search was performed, and all studies found on each ingredient were analyzed. In summary, all analyzed ingredients mentioned in this review are well described in scientific studies on their beneficial effect for oral health and can be used to expand the preventive effect of hydroxyapatite in oral care products.

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Clinical aspects of the use of lactoferrin in dentistry

Cited by 16 publications

References 40 publications

Antibiotic treatment and supplemental hemin availability affect the volatile organic compounds produced by P. gingivalis in vitro

Antibiotic treatment and supplemental hemin availability affect the volatile organic compounds produced by P. gingivalis in vitro

Advancements in Biodegradable Active Films for Food Packaging: Effects of Nano/Microcapsule Incorporation

Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products

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