Clinical and radiological features of odontogenic ghost cell carcinoma: review of the literature and report of four new cases

Cheng, Yong; Long, Xing; Li, X; Bian, Zhaonan; Chen, X; Yang, Xin

doi:10.1259/dmfr/67909783

Cited by 46 publications

(56 citation statements)

References 18 publications

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“…In addition, 89% (17/19) showed poorly defined borders and 11% (2/19) showed well defined borders. Root resorption was reported in 31% (6/19) of patients, and tooth displacements in 21% (4/19) 93,94,95…”

Section: Ghost Cell Odontogenic Carcinomamentioning

confidence: 99%

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Lee

Kim

2014

Korean J Pathol

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Calcifying epithelial odontogenic tumors (CEOTs) and ghost cell odontogenic tumors (GCOTs) are characteristic odontogenic origin epithelial tumors which produce calcifying materials from transformed epithelial tumor cells. CEOT is a benign odontogenic tumor composed of polygonal epithelial tumor cells that show retrogressive calcific changes, amyloid-like deposition, and clear cytoplasm. Differentially, GCOTs are a group of transient tumors characterized by ghost cell presence, which comprise calcifying cystic odontogenic tumor (CCOT), dentinogenic ghost cell tumor (DGCT), and ghost cell odontogenic carcinoma (GCOC), all derived from calcifying odontogenic cysts (COCs). There is considerable confusion about COCs and GCOTs terminology, but these lesions can be classified as COCs or GCOTs, based on their cystic or tumorous natures, respectively. GCOTs include ameloblastomatous tumors derived from dominant odontogenic cysts classified as CCOTs, ghost cell-rich tumors producing dentinoid materials as DGCTs, and the GCOT malignant counterpart, GCOCs. Many authors have reported CEOTs and GCOTs variably express keratins, β-catenin, BCL-2, BSP, RANKL, OPG, Notch1, Jagged1, TGF-β, SMADs, and other proteins. However, these heterogeneous lesions should be differentially diagnosed to allow for accurate tumor progression and prognosis prediction.

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Section: Ghost Cell Odontogenic Carcinomamentioning

confidence: 99%

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Lee

Kim

2014

Korean J Pathol

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“…Ghost cell odontogenic carcinoma, a malignant counterpart of the calcifying odontogenic cyst, is an exceptionally rare malignant odontogenic tumour. To our knowledge, since Ikemura et al (1985) reported a well-documented case of calcifying odontogenic cyst with malignant transformation, 25 cases of ghost cell odontogenic carcinoma have been reported in the English-language literature (Grodjesk et al, 1987;Alcalde et al, 1996;Lu et al, 1999;Cheng et al, 2004;Goldenberg et al, 2004;Sun et al, 2007). Although it often presents with symptomatic swelling in the jaws and shows osseous destruction, tartrate-resistant acid phosphatase (TRAP), and vitronectin receptor, both osteoclast-related cytokines, have not been described in this carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Ghost cell odontogenic carcinoma of the mandible: A case report demonstrating expression of tartrate-resistant acid phosphatase (TRAP) and vitronectin receptor

Roh

Jeon

Park

et al. 2008

Journal of Cranio-Maxillofacial Surgery

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“…Table 1 provides a concise review of the literature on clinical and pathological characteristics of GCOC [3, 5, 6, 9–17]. Here, the recurrent case was considered a benign lesion.…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature

Mokhtari

Mohsenifar

Ghorbanpour

2013

Case Reports in Pathology

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Calcifying cystic odontogenic tumor (CCOT) demonstrates considerable diversity in histopathology and clinical behavior. Ghost cell odontogenic carcinoma (GCOC) is the rare malignant counterpart of CCOT and it frequently arises from malignant transformation of a recurrent CCOT. In this paper, we present a case of CCOT and discuss its distinct histopathologic features in recurrence. Then, we will have a review on clinical, histopathological, and immunohistochemical aspects of GCOC in the literature. Predictive factors of malignant transformation in a benign CCOT will also be discussed.

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Clinical and radiological features of odontogenic ghost cell carcinoma: review of the literature and report of four new cases

Abstract: OGCC demonstrates clinical and radiographic features of a malignant tumour with high recurrence.

Cited by 46 publications

References 18 publications

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Ghost cell odontogenic carcinoma of the mandible: A case report demonstrating expression of tartrate-resistant acid phosphatase (TRAP) and vitronectin receptor

Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature

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