Ghost cell odontogenic carcinoma of the mandible: A case report demonstrating expression of tartrate-resistant acid phosphatase (TRAP) and vitronectin receptor

Roh, Gu Seob; Jeon, Byeong Tak; Park, Bong-Wook; Kim, Deok Ryong; Hah, Young‐Sool; Kim, Jin Hyun; Byun, June‐Ho

doi:10.1016/j.jcms.2008.06.001

Cited by 24 publications

(15 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Jaw expansion with or without pain is the most common clinical presentation, which may also be associated with local paraesthesia, tooth mobility or displacement. Few patients had enlarged neck lymph nodes, but metastasis was extremely rare 3,9. With regard to CCOT, the tumor mainly manifested as gradual expansion of the jaw with occasional pain, probably on account of increased periosteal tension and compression of adjacent nerves and vessels by the expanding mass.…”

Section: Discussionmentioning

confidence: 99%

Ghost Cell Odontogenic Carcinoma Arising from Calcifying Cystic Odontogenic Tumor: A Case Report

et al. 2012

View full text Add to dashboard Cite

Ghost cell odontogenic carcinoma (GCOC) is an exceptionally rare and malignant odontogenic tumor with aggressive growth characteristics. We describe a case of GCOC which was considerably derived from a previously resected calcifying cystic odontogenic tumor (CCOT). Cellular atypia, mitotic activity, Ki-67 labeling index and matrix metalloprotease-9 positive expression rate were all increased in the currently resected specimen compared to the initial one. This is a rare case of malignant transformation of CCOT to GCOC with respect to its histopathological and immunohistochemical findings.

show abstract

Section: Discussionmentioning

confidence: 99%

Ghost Cell Odontogenic Carcinoma Arising from Calcifying Cystic Odontogenic Tumor: A Case Report

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Despite their retrogressive and apoptotic status, GCOC ghost cells consistently express BAX and vitronectin receptor proteins, and are strongly positive for the tartrate-resistant acid phosphatase reaction 99. These facts indicate anucleated ghost cells still play important roles in the extensive bone resorption observed in GCOC 91,98…”

Section: Ghost Cell Odontogenic Carcinomamentioning

confidence: 96%

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Lee

Kim

2014

Korean J Pathol

View full text Add to dashboard Cite

Calcifying epithelial odontogenic tumors (CEOTs) and ghost cell odontogenic tumors (GCOTs) are characteristic odontogenic origin epithelial tumors which produce calcifying materials from transformed epithelial tumor cells. CEOT is a benign odontogenic tumor composed of polygonal epithelial tumor cells that show retrogressive calcific changes, amyloid-like deposition, and clear cytoplasm. Differentially, GCOTs are a group of transient tumors characterized by ghost cell presence, which comprise calcifying cystic odontogenic tumor (CCOT), dentinogenic ghost cell tumor (DGCT), and ghost cell odontogenic carcinoma (GCOC), all derived from calcifying odontogenic cysts (COCs). There is considerable confusion about COCs and GCOTs terminology, but these lesions can be classified as COCs or GCOTs, based on their cystic or tumorous natures, respectively. GCOTs include ameloblastomatous tumors derived from dominant odontogenic cysts classified as CCOTs, ghost cell-rich tumors producing dentinoid materials as DGCTs, and the GCOT malignant counterpart, GCOCs. Many authors have reported CEOTs and GCOTs variably express keratins, β-catenin, BCL-2, BSP, RANKL, OPG, Notch1, Jagged1, TGF-β, SMADs, and other proteins. However, these heterogeneous lesions should be differentially diagnosed to allow for accurate tumor progression and prognosis prediction.

show abstract

“…Clinically, OGCC may appear as a de novo tumor or may arise as a previously diagnosed COC (3,(6)(7)(8)(9). It is of interest that previous cases of OGCC are often described as multiple recurrences of COC or long-term persistent swelling followed by the onset of rapid, painful swelling before a definitive diagnosis of OGCC (5,10,11). This might be perceived as evidence of a transformation of a long-standing or recurrent benign process into a malignant one.…”

Section: Negative Negativementioning

confidence: 99%

Recurrent odontogenic ghost cell carcinoma (OGCC) at a reconstructed fibular flap: A case report with immunohistochemical findings

Li¹,

Cho²,

Kim³

et al. 2011

Med Oral

View full text Add to dashboard Cite

Odontogenic ghost cell carcinoma (OGCC), a malignant counterpart of the odontogenic ghost cell tumor (OGCT), with aggressive growth characteristics, is exceedingly rare. A painful swelling in the jaw with local paresthesia is the most common symptom. We described a case of 47-year Korean woman who had a rare central epithelial odontogenic ghost cell carcinoma which recurred at reconstructed fibular flap. Immunohistochemical differences between OGCT and OGCC analyzed using primary and recurred surgical specimen. On the basis of this case, the tumor started as an OGCT and transformed into OGCC with highly aggressive, rapidly growing, infiltrative tumors. Our findings suggest that some of the cytokines produced by ghost cells may play important roles in causing extensive bone resorption in the odontogenic ghost cell carcinoma. Wide local excision with histologically clean margins is the treatment mode of selection. Also, we recommend close long-term surveillance of OGCT because of high recurrence and potential for malignancy transformation.

show abstract

Ghost cell odontogenic carcinoma of the mandible: A case report demonstrating expression of tartrate-resistant acid phosphatase (TRAP) and vitronectin receptor

Cited by 24 publications

References 18 publications

Ghost Cell Odontogenic Carcinoma Arising from Calcifying Cystic Odontogenic Tumor: A Case Report

Ghost Cell Odontogenic Carcinoma Arising from Calcifying Cystic Odontogenic Tumor: A Case Report

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Recurrent odontogenic ghost cell carcinoma (OGCC) at a reconstructed fibular flap: A case report with immunohistochemical findings

Contact Info

Product

Resources

About