Clinical and radiographic evaluation of intrabony periodontal defect treatment by open flap debridement alone or in combination with nanocrystalline hydroxyapatite bone substitute

Pietruska, Małgorzata; Skurska, Anna; Pietruski, J; Dolińska, Ewa; Arweiler, Nicole Birgit; Milewski, Robert; Duraj, Ewa; Sculean, Anton

doi:10.1016/j.aanat.2012.03.009

Cited by 16 publications

(15 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After 6 months, the two randomized controlled clinical studies reported a higher clinical attachment gain of 4.4 ± 1.7 mm and 4.3 ± 1.4 mm, respectively, and PPD reductions of 3.4 ± 1.2 mm and 4.3 ± 1.1 mm, respectively, after papilla preservation flap surgery with or without the application of a NHA in intrabony periodontal defects of ≥4 mm in a split-mouth design. On the contrary, another clinical study showed that the additional use of NHA combined with an open flap procedure does not improve clinical and radiographic treatment outcomes [31]. However, NHA was used in the form of granules in contrast to paste used in the here presented study.…”

Section: Discussionmentioning

confidence: 74%

Clinical Outcomes after Treatment of Periodontal Intrabony Defects with Nanocrystalline Hydroxyapatite (Ostim) or Enamel Matrix Derivatives (Emdogain): A Randomized Controlled Clinical Trial

Machot

Hoffmann

Lorenz

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Introduction. Periodontitis is an inflammatory process in response to dental biofilm and leads to periodontal tissue destruction. The aim of this study was the comparison of outcomes using either an enamel matrix derivative (EMD) or a nanocrystalline hydroxyapatite (NHA) in regenerative periodontal therapy after 6 and 12 months. Methods. Using a parallel group, prospective randomized study design, we enrolled 19 patients in each group. The primary outcome was bone fill after 12 months. Attachment gain, probing pocket depth (PPD) reduction, and recession were secondary variables. Additionally, early wound healing and adverse events were assessed. Data analysis included test of noninferiority of NHA group (test) compared to EMD group (reference) in bone fill. Differences in means of secondary variables were compared by paired t-test, frequency data by exact χ 2 test. Results. Both groups showed significant bone fill, reduction of PPD, increase in recession, and gain of attachment after 6 and 12 months. No significant differences between groups were found at any time point. Adverse events were comparable between both groups with a tendency of more complaints in the NHA group. Conclusion. The clinical outcomes were similar in both groups. EMD could have some advantage compared to NHA regarding patients comfort and adverse events. The trial is registered with ClinicalTrials.gov NCT00757159.

show abstract

Section: Discussionmentioning

confidence: 74%

Clinical Outcomes after Treatment of Periodontal Intrabony Defects with Nanocrystalline Hydroxyapatite (Ostim) or Enamel Matrix Derivatives (Emdogain): A Randomized Controlled Clinical Trial

Machot

Hoffmann

Lorenz

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…For periodontal bone defects ( Table 6 ), 20 studies involving RCTs [ 10 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 ] and prospective CCTs [ 9 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 ] reported a parallel [ 79 , 84 , 87 ] or split mouth [ 10 , 81 , 83 , 86 ] design. The study population consisted of 12–263 persons (age, 14–75 years) divided into two to four study groups with a follow-up of 1–24 months after grafting.…”

Section: Resultsmentioning

confidence: 99%

The use of hydroxyapatite bone substitute grafting for alveolar ridge preservation, sinus augmentation, and periodontal bone defect: A systematic review

Dewi

Ana

2018

Heliyon

View full text Add to dashboard Cite

ObjectivesWe determined and structurally analyzed the reported effect of hydroxyapatite (HA) bone substitute on alveolar bone regeneration. To the best of our knowledge, no systematic reviews have previously reported the bone regenerative effect of the HA bone substitute.Materials and methodsA literature search was performed for articles published up to August 2015 using MEDLINE with the search terms “hydroxyapatite,” “bone regeneration,” and “alveolar bone” as well as their known synonyms. The inclusion criteria were set up for human trials with at least five patients. The literature search, eligible article selection, and data extraction were independently performed by two readers, and their agreement was reported by κ value.ResultsOf the 504 studies found using the MEDLINE literature search, 241 were included for further steps (inter-reader agreement, κ = 0.968). Abstract screening yielded 74 studies (κ = 0.910), with 42 completely fulfilling the inclusion criteria (κ = 0.864). In a final step, 42 studies were further analyzed, with 17 and 25 studies with and without statistical analysis, respectively. The 17 studies reporting similar outcome measures were compared using the calculated 95% confidence intervals. The effect of HA on ridge preservation could not be evaluated.ConclusionsThe use of the HA bone substitute interfered with the normal healing process, with significant differences found for sinus augmentation but not for periodontal bone defects. Thus, a bone substitute with optimal bone regenerative properties for alveolar ridge or socket preservation, sinus augmentation, and periodontal bony defect should be developed.

show abstract

“…La HA en injertos óseos presentó los siguientes resultados: a) peso: sólo dos estudios (Pietruska et al;Schwarz et al, 2009) poseen un peso que supera el 20%, existiendo 2 estudios con que tienen un peso inferior al 10%. B) OR: entendido como el cociente de dos razones, el numerador es la razón de la probabilidad de que un evento suceda y la probabilidad de que no suceda bajo ciertas condiciones y el denominador es la razón de la probabilidad de que dicho evento suceda y la probabilidad de que no suceda bajo las condiciones complementarias (Fig.…”

Section: Resultsunclassified

“…Los efectos positivos de la HA se atribuyen a la alta respuesta angiogénica y biocompatibilidad del material, mejorando así, la reparación ósea (Pietruska et al, 2012).…”

Section: Introductionunclassified

Eficacia de la Hidroxiapatita en la Cicatrización de Injertos Óseos e Implantes Dentales: una Revisión Sistemática de la Literatura

2014

Int. J. Odontostomat.

View full text Add to dashboard Cite

RESUMEN:La hidroxiapatita (HA) es un componente mineral del hueso. Se ha comercializado la HA sintética o aloplástica en forma porosa o no porosa, densa y reabsorbible o no reabsorbible. Se utiliza como injerto óseo dada sus propiedades osteoconductivas y estimuladoras de proliferación celular generando así condiciones favorables para la regeneración tisular. El objetivo fue evaluar la efectividad del tratamiento con HA en cirugías de implantes dentales e injertos óseos. Se realizó una revisión sistemática. Se revisó ensayos clínicos sobre cicatrización y los injertos de HA sintética en Pubmed, Cochrane Library, Google Académico, Blackwell y Ebsco. Los criterios de selección son pacientes candidatos a tratamientos de defectos periodontales o rehabilitación con implantes dentales, sin alteraciones sistémicas de importancia. La estrategia se resume en los siguientes puntos: Identificación del problema, Identificación de términos de búsqueda, Búsqueda sistemática, Selección de artículos mediante utilización de guías de análisis crítico, Incorporación de la información al REVMAN®, Análisis de sesgos y Metaanálisis. Al evaluar el metaanálisis se observa que la HA es efectiva para la cicatrización de injerto óseo. Cuando se omiten los estudios de bajo peso, la medida de resumen se mantiene en la HA. El tratamiento con HA en la cicatrización ósea y de implantes dentales resulta positivo y con una alta tasa de éxito en el largo plazo aunque su rango de efectividad varía con los materiales a los cuales ésta se asocie.

show abstract

Clinical and radiographic evaluation of intrabony periodontal defect treatment by open flap debridement alone or in combination with nanocrystalline hydroxyapatite bone substitute

Cited by 16 publications

References 22 publications

Clinical Outcomes after Treatment of Periodontal Intrabony Defects with Nanocrystalline Hydroxyapatite (Ostim) or Enamel Matrix Derivatives (Emdogain): A Randomized Controlled Clinical Trial

Clinical Outcomes after Treatment of Periodontal Intrabony Defects with Nanocrystalline Hydroxyapatite (Ostim) or Enamel Matrix Derivatives (Emdogain): A Randomized Controlled Clinical Trial

The use of hydroxyapatite bone substitute grafting for alveolar ridge preservation, sinus augmentation, and periodontal bone defect: A systematic review

Eficacia de la Hidroxiapatita en la Cicatrización de Injertos Óseos e Implantes Dentales: una Revisión Sistemática de la Literatura

Contact Info

Product

Resources

About