Clinical and Pathological Analysis of Recurrent Inverted Papilloma

Oikawa, Keita; Furuta, Yasushi; Itoh, Tomoo; Fukuda, Satoshi

doi:10.1177/000348940711600414

Cited by 22 publications

(18 citation statements)

References 17 publications

(28 reference statements)

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“…With endoscopic medial maxillectomy, the recurrence rate according to Sukenik and Casiano was 21% [55] and 0% in a series from Tomenzoli et al [56]. Current recurrence rates using endoscopic resections, however, vary from 0% to 44% [12,57]. In our study, we detected recurrences in 14 of 68 (20.5%) patients within a period from 2 months up to 11 years.…”

Section: Discussionsupporting

confidence: 48%

“…The typical presentation of IPs is a unilateral and unicentric polypoid lesion on the lateral wall of the nasal cavity. Histologically, IPs are characterized by invagination of the hyperplastic epithelium, ranging from squamous to ciliated columnar with goblet cells into the underlying stroma [9][10][11][12][13]. Recurrence rates differ significantly, ranging from 6% to 33%, and are probably due to incomplete excisions [14].…”

Section: Introductionmentioning

confidence: 99%

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In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

et al. 2011

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Inverted papillomas (IPs) are the most frequent type of sinonasal papillomas. These benign but destructive lesions are known for their high recurrence rate, probably due to incomplete excision. Our aim was to investigate the frequency of human papillomavirus (HPV) infection in patients with IPs and in IPs associated with squamous cell carcinoma (IPsSCC) and to compare it with the frequency of HPV infections in the control group. The influence of HPV infection on the malignant alteration and recurrence rate of IPs was also evaluated. Paraffin-embedded tissue samples from 68 patients with sinonasal IPs and 5 patients with IPsSCC were analyzed in this retrospective study. The control group consisted of 47 patients who had undergone septoplasty or mucotomy of the inferior turbinate. PCR amplification with consensus primer sets was performed to detect alpha-HPVs, and direct sequencing of the PCR products with the same primers was used to determine the HPV genotypes in the samples. We detected HPV DNA in 20 (30.3%) patients with IPs, in 3 (60%) patients with IPsSCC, and in 6 (13%) patients from the control group. The frequency of HPV infection in the study group was statistically significantly higher (p = 0.032) than in the control group. The presence of HPV DNA was not a statistically significant predictor of the recurrence of IPs (p = 0.745) nor was it a statistically significant risk factor for associated SCC (p = 0.32). Since HPV type 11 was the predominant genotype in the IPs, IPsSCC, and in the control cases, we presume that HPV infection may represent incidental colonization rather than being an important etiological factor of IPs.

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Section: Discussionsupporting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

et al. 2011

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“…The mean age at recurrence of sinonasal inverted papilloma was reported to range from 49 to 70 years, and there were 24 male and 6 female patients. 18,19 Our current study actually suggested a median age of 46 years and a male predominance of 4:3, which was in agreement with these previous data. The mean age of the patients who underwent endoscopic and open resection was 41 years and 50 years, respectively.…”

Section: Discussionsupporting

confidence: 93%

Clinical Outcomes of Endoscopic and Open Resection of Recurrent Sinonasal Inverted Papilloma

Gu¹,

Zhang

2014

Journal of Craniofacial Surgery

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“…They estimated that the malignant potential for recurrent disease was up to 11%. In another series of thirteen inverted papilloma, eleven (85%) had recurrence in the ethmoid sinus, particularly at the lamina papyracea (n = 8; 62%) [15]. Recurrence over lamina papyracea can be minimized by its removal during medial maxillectomy or thinning by diamond or cutting burr during endoscopic procedure.…”

Section: Discussionmentioning

confidence: 99%

Inverted Papilloma: A Clinico-Pathological Dilemma with Special Reference to Recurrence and Malignant Transformation

Ghosh

Sen

Chandra

et al. 2010

Indian J Otolaryngol Head Neck Surg

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To study the clinicopathological profile, recurrence and malignant potential of the inverted papilloma of nose and paranasal sinuses in relation to the definitive diagnosis and the management undertaken. A total number of 52 cases of histologically proven inverted papilloma managed in our department of otolaryngology over a 10-year period (May 1998-April 2008) were followed up (until October 2009) and the results were analyzed retrospectively to find out any incidence of recurrence of these tumours. A total of 52 inverted papilloma cases were managed with different surgical interventions. Male:female ratio was found to be 10:1. The mean follow up period was 74 months (range 16 months-11 years). Recurrence was observed in 20 (38%) cases. 23% had recurrence without any specific histological pattern, 12% had recurrence with focal dysplasia and 4% had recurrence with malignant transformation into squamous cell carcinoma (SCC). Post-operative radiotherapy was given to 8% (four cases) with malignant transformation. The management of inverted papilloma depends on its size and extension. Recurrence can be minimized by an appropriate surgical planning. Careful endoscopic assessment is essential to detect early recurrence. Recurrent inverted papilloma should be treated more aggressively. Malignant transformation in inverted papilloma should be managed like any aggressive sino-nasal malignancy.

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Clinical and Pathological Analysis of Recurrent Inverted Papilloma

Cited by 22 publications

References 17 publications

In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

Clinical Outcomes of Endoscopic and Open Resection of Recurrent Sinonasal Inverted Papilloma

Inverted Papilloma: A Clinico-Pathological Dilemma with Special Reference to Recurrence and Malignant Transformation

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