Clinical and Microbiological Evaluation of Brazilian Red Propolis Containing‐Dentifrice in Orthodontic Patients: A Randomized Clinical Trial

Abstract

Aim. To evaluate the efficacy of dentifrice containing brazilian red propolis (BRP) in adolescents under orthodontic treatment. Materials and Methods. This is a randomized, double-blind, clinical trial. A total of 92 participants free from caries were randomized into 2 groups; the first received fluoride dentifrice, and the second received fluoride dentifrice incorporated with BRP. The gingival bleeding index (GBI) was recorded, and saliva was collected on the baseline (D0) and after 28 days (D28) for microbiological analysis. Data from GBI and Colony Forming Units (CFU) (log10) were expressed as mean and standard deviation. Results. The two groups reduced GBI significantly, with no difference in the intergroup analysis. In the intragroup analysis, it was observed that G2 (p<0.001) had a significant reduction for Gram-negative bacteria, while there was significance (p<0.001) in the intergroup analysis when compared with G1. For S. mutans bacteria, it was observed that only G2 had a statistically significant reduction (p<0.001), and there was significant reduction (p=0.006) in the intergroup analysis of the G2 group when compared with G1. Conclusions. Dentifrice containing BRP demonstrated better clinical and microbiological activity. Future studies are needed to better identify effects to establish the use of dentifrice containing propolis in biofilm control.

Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease

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Evaluation of fluoride concentration in toothpastes with antimicrobial molecules commercialized in Brazil

“…The addition of natural extracts in toothpaste formulations is something that is increasingly growing, which requires evaluating the quality of the formulation (Furtado Júnior et al 2020). The presence of natural bioactive agents can cause interactions and influence on the fluorine bioavailability in toothpaste formulations.…”

Evaluation of the Effects of Propolis and Xylitol Chewable Tablets on the Salivary Concentrations of Oral Micro-organisms in Orthodontic Patients: A Pilot Study

“…Besides mouthrinses, toothpastes are the most commonly found formulations. 1,6,18 It is known that orthodontic appliances facilitate the accumulation of biofilm, which can cause microbiota imbalance. Thus, antibacterial substances can be used to destabilize the biofilm in individuals with difficult control of dental plaque.…”

“…4,5 It is known that the use of fixed orthodontic appliances facilitates the formation of plaque stagnation areas, increasing the susceptibility to demineralization around the brackets and gingivitis. 6 Gram-negative cocci of the genus Branhamella are also potentially pathogenic to the oral mucosa. They are found singly or as diplococci.…”