Clinical and Laboratory Characteristics and Risk Factors for Fatality in Elderly Patients with Dengue Hemorrhagic Fever

Lee, Ing-Kit; Liu, Jien-Wei; Yang, Kuender D.

doi:10.4269/ajtmh.2008.79.149

Cited by 111 publications

(129 citation statements)

References 32 publications

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“…The high fatality in the elderly is concordant with samples analysed in different countries [11][12][13][14][15][16], implying an influence of age independent from ethnicity or local epidemiological aspects. Even with different serotypes circulating in the study period, in all years the proportion of elderly individuals presenting severe dengue was higher than the sample average.…”

Section: Discussionsupporting

confidence: 69%

Influence of demographics on clinical outcome of dengue: a cross-sectional study of 6703 confirmed cases in Vitória, Espírito Santo State, Brazil

Vicente¹,

Cerutti

Fröschl³

et al. 2016

Epidemiol. Infect.

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SUMMARYDengue presents a wide clinical spectrum of signs and symptoms, with characteristics of the host potentially influencing the disease evolution. Therefore, the purpose of this study was to evaluate the influence of gender and age on dengue clinical outcomes in a recent outbreak situation in Brazil, applying a cross-sectional design and including 6703 dengue cases with laboratory confirmation, occurring in Vitória, Espírito Santo State, Brazil, between 2007 and 2013. Data were obtained from the Information System for Notifiable Diseases. Overall, 11·3% of the sample presented with severe dengue, which affected 13·0% of males, 10·0% of females, 8·8% of children, 12·5% of adolescents, 10·5% of adults and 15·5% of the elderly. Age was higher in the severe dengue group (P = 0·03). Severe dengue was associated with males and the elderly (P < 0·01); however, considering only severe cases, children presented haemorrhage and plasma leakage more frequently than older age groups. The results emphasize the importance of a differentiated protocol for management of dengue cases, taking into consideration host factors like age. These findings also suggest the elderly and children as priority groups for immunization in a future implementation of a vaccine.

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Section: Discussionsupporting

confidence: 69%

Influence of demographics on clinical outcome of dengue: a cross-sectional study of 6703 confirmed cases in Vitória, Espírito Santo State, Brazil

Vicente¹,

Cerutti

Fröschl³

et al. 2016

Epidemiol. Infect.

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“…Con relación a los signos y síntomas en el momento del diagnóstico, al igual que en otras series (3,(18)(19)(20)(21), en este estudio se encontró que la fiebre, las mialgias, la cefalea y las artralgias fueron los más frecuentes (cuadro 5).…”

Section: Discussionunclassified

“…En el presente estudio se encontró infección bacteriana concomitante en tres pacientes (8 %), lo cual es similar a lo reportado en series del sudeste asiático en donde los pacientes que desarrollaron infecciones asociadas a la atención en salud también presentaron neutrofilia (19,21,25). Otra complicación que se reporta con frecuencia en esta población es la falla renal aguda, aunque en este estudio solo tres pacientes presentaron esta condición y requirieron internación en la unidad de cuidados intensivos (19).…”

Section: Discussionunclassified

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Prevalencia y curso clínico de la infección por dengue en adultos mayores con cuadro febril agudo en un hospital de alta complejidad en Cali, Colombia

Rosso¹,

Vanegas

Rodríguez

et al. 2016

biomedica

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Contribución de los autores:Róbinson Pacheco y Fernando Rosso: desarrollo de la idea, diseño del estudio y revisión crítica del contenido Sarita Rodríguez: creación de la base de datos, análisis de la información, revisión crítica del contenido Sara Vanegas: revisión de la literatura, diseño del estudio, recolección de datos y análisis de la información Todos los autores participaron en la redacción del manuscrito.Prevalencia y curso clínico de la infección por dengue en adultos mayores con cuadro febril agudo en un hospital de alta complejidad en Cali, Colombia Introducción. Hay pocas series de casos publicadas sobre la prevalencia y el curso clínico del dengue en adultos mayores con síndrome febril, habitantes en zonas endémicas para la infección. Se cree que tales casos presentan una baja prevalencia pero revisten mayor gravedad, y más complicaciones y mortalidad. Objetivos. Describir la prevalencia y el curso clínico del dengue en adultos mayores atendidos por síndrome febril agudo en un hospital de alta complejidad de una zona endémica de la enfermedad. Introduction: Little is known about the prevalence and clinical course of dengue infection in elderly patients living in endemic areas; it is presumed that there is a lower prevalence but higher severity, complications and mortality. Objective: To describe the prevalence and clinical course of dengue infection in elderly patients who were admitted to a referral care center for infectious diseases in an endemic region. Materials and methods:We conducted an observational and descriptive study between 2011 and 2014, using a cohort of elderly patients with serological diagnosis of dengue.Results: A total of 235 febrile elderly patients were assessed, of which 43 patients (18.3%) were found to have dengue. The median age was 71 years; 48.7% were female, and 89% of patients had at least one comorbid condition. According to the serological tests, 51.4% of cases were positive for NS1 Ag, 27% for IgM and 54.1% for IgG, while 64.8% were secondary infections. Dengue was diagnosed in 13 patients (35%), dengue with warning signs in 16 cases (43%), and severe dengue in 8 cases (22%). Nearly 56.7% of patients were admitted to hospital and 21.6%, to the intensive care unit. None died. 180Biomédica 2016;36(Supl.2):179-86 Rosso F, Pacheco R, Rodríguez S, Vanegas S Conclusion: We found dengue infection to be more frequent than expected in this sample of elderly patients, due to acute febrile syndrome. Elderly patients also required higher rate of hospitalization and had more complications, however there were no deaths due to good management.

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“…Patrones similares se han reportado en México (35) y Tailandia, aunque en periodos diferentes (36,37). En los grupos de más edad, el riesgo de morir aumenta y probablemente está asociado con el incremento del número de enfermedades concomitantes y con una mayor propensión a contraer infecciones en general (38,39); también se ha aducido la transición demográfica (40).…”

Section: Materiales Y Métodosunclassified

Comportamiento de la mortalidad por dengue en Colombia entre 1985 y 2012

2016

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Recibido: 30/07/15; aceptado: 10/02/16 Contribución de los autores:Todos los autores participaron en el diseño del estudio, el análisis estadístico, la discusión de resultados y la redacción del manuscrito. Comportamiento de la mortalidad por dengue en Colombia entre 1985 y 2012Pablo Chaparro-Narváez, Willian León-Quevedo, Carlos Andrés Castañeda-Orjuela Introduction: Dengue in Colombia is an important public health problem due to the huge economic and social costs it has caused, especially during the disease outbreaks. Objective: To describe the behavior of dengue mortality in Colombia between 1985 and 2012. Materials and methods:We conducted a descriptive study. Information was obtained from mortality and population projection databases provided by the Departamento Administrativo Nacional de Estadística (DANE) for the 1985-2012 period. Mortality rates, rate ratios, and case fatality rates were estimated. Results: A total of 1,990 dengue deaths were registered during this period in Colombia. Dengue mortality rates presented an increasing trend with statistical significance between 1985 and 1998. Higher mortality rates were reported in men both younger than 5 years and older than 65 years. Between 1995 and 2012, category 1 to 4 municipalities reported the highest mortality rates. Case fatality rates varied during the period between 0.01% and 0.39%. Conclusion:Dengue is an avoidable disease that should disappear from mortality statistics as a cause of death. The event is avoidable if the proposed activities from the Estrategia de Gestión Integrada (EGI)-Dengue are implemented and evaluated. We recommend encouraging the development of an informational culture to contribute to decision making and prioritizing resource allocation.

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Clinical and Laboratory Characteristics and Risk Factors for Fatality in Elderly Patients with Dengue Hemorrhagic Fever

Cited by 111 publications

References 32 publications

Influence of demographics on clinical outcome of dengue: a cross-sectional study of 6703 confirmed cases in Vitória, Espírito Santo State, Brazil

Influence of demographics on clinical outcome of dengue: a cross-sectional study of 6703 confirmed cases in Vitória, Espírito Santo State, Brazil

Prevalencia y curso clínico de la infección por dengue en adultos mayores con cuadro febril agudo en un hospital de alta complejidad en Cali, Colombia

Comportamiento de la mortalidad por dengue en Colombia entre 1985 y 2012

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