Clinical and immunologic findings of methylene diphenyl diisocyanate‐induced occupational asthma in a car upholstery factory

Gy, Hur; Dh, Koh; Gs, Choi; Hj, Park; Sj, Choi; Ym, Ye; Ks, Kim; Hs, Park

doi:10.1111/j.1365-2222.2008.02935.x

Cited by 39 publications

(45 citation statements)

References 38 publications

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“…Although it is well known that mastocytosis can lead to the development of non-IgE-mediated severe intraoperative reactions, without standard guidelines for the intraoperative management of these patients, premedication consisted of antihistamines, corticosteroids, and disodium cromoglycate by means of nebulization and the oral route; stress-reducing ansiolitics were administered, and safer anesthetic drugs were used. 7,8 No undesired intraoperative or postoperative reactions occurred.…”

Section: Mast Cell Diseases and The Severity And Course Of Intraoperamentioning

confidence: 95%

“…The results of a previous study suggest that the presence of MDI specific IgG antibodies might be predictive of MDI-OA. 8 Specifically, we investigated the possible association between HLA alleles and MDI specific IgG or IgE antibody production. We found that single allelic frequencies of DRB1*0901, DQB1*0303, and DPB1*0501 did not demonstrate significant associations with the presence of MDI specific IgG or IgE antibodies; however, the haplotype frequency DRB1*0901-DQB1*0303-DPB1*0501 was significantly associated with the presence of serum specific IgG to MDI-HSA conjugate.…”

mentioning

confidence: 99%

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HLA CLASS II ALLELE AND IgG SENSITIZATION TO METHYLENE DIISOCYANATE IN EXPOSED WORKERS

Hur

Lee

et al. 2009

Annals of Allergy, Asthma & Immunology

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Section: Mast Cell Diseases and The Severity And Course Of Intraoperamentioning

confidence: 95%

mentioning

confidence: 99%

HLA CLASS II ALLELE AND IgG SENSITIZATION TO METHYLENE DIISOCYANATE IN EXPOSED WORKERS

Hur

Lee

et al. 2009

Annals of Allergy, Asthma & Immunology

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“…Some investigators have suggested that serum-specific IgE and IgG antibodies are increased in some MDI-sensitized workers [3][4][5][6]. In our previous study, serum-specific IgE and IgG antibodies were shown to be increased in some MDI-induced occupational asthma (MDI-OA) patients, of which specific IgG antibodies were more associated with work-related respiratory symptoms (WRRS) [7]. Activated neutrophils have also been suggested to play a role in the pathogenic mechanisms of toluene diisocyanate-induced occupational asthma (TDI-OA) [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…All subjects with MDI-OA, MDI-EB, and AEC were recruited from a previous study population of 58 MDI-exposed workers in a single car upholstery factory [7]. The diagnosis of MDI-OA was confirmed by methacholine challenge test and MDI-specific inhalation challenge test.…”

Section: Study Subjectsmentioning

confidence: 99%

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Histamine Release and Inflammatory Cell Infiltration in Airway Mucosa in Methylene Diphenyl Diisocyanate (MDI)-Induced Occupational Asthma

et al. 2008

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Introduction Although methylene diphenyl diisocyanate (MDI) is widely used in industries, there have been few studies of the pathogenic mechanisms of MDI-induced occupational asthma (MDI-OA). Methods We performed immunohistochemical analyses, measured inflammatory mediators and cytokines, and quantified histamine release (HR) from peripheral basophils in MDI-OA patients. Thirteen MDI-exposed workers (five MDI-OA, two MDI-induced esoinophilic bronchitis, and six asymptomatic exposed controls, AEC) were enrolled. Results and Discussion Immunochemical analyses indicated significantly increased anti-eosinophilic cationic proteinstained cells in MDI-OA patients as compared with controls (P<0.05). Sputum eosinophil cationic protein levels were increased after MDI-specific inhalation challenge test in MDI-OA/EB patients (P<0.02). Sputum eosinophil counts were highly correlated with IL-8 and MMP-9 levels (P<0.05 and P<0.01, respectively). Basophil HR was significantly increased in MDI-OA patients after stimulations with anti-IgG4 and MDI-human serum albumin conjugates (both P<0.05). Eosinophil activation is a major feature of airway inflammation in MDI-OA patients. Increased HR by MDI may contribute to the pathogenic mechanisms of MDI-OA.

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Diisocyanates, occupational asthma and IgE antibody: implications for hazard characterization

Kimber

Dearman

Basketter

2014

J of Applied Toxicology

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Sensitization of the respiratory tract by chemicals resulting in rhinitis and asthma is an important occupational health issue. Occupational asthma is associated with significant morbidity and can be fatal. Tests for the identification and characterization of chemicals with the potential to cause sensitization of the respiratory tract are lacking. In spite of sustained interest there are no validated or widely accepted methods available, and this presents toxicologists with a considerable challenge. One important constraint on the development of appropriate testing strategies has been uncertainty and controversy about the immunological mechanisms through which chemicals may induce sensitization of the respiratory tract. By analogy with protein respiratory allergy it is legitimate to consider that IgE antibody-dependent mechanisms may play a pivotal role. However, although many aspects of chemical respiratory allergy are consistent with reactions caused by IgE antibody, uncertainty remains because among patients with occupational asthma caused by chemical respiratory allergens there are commonly a proportion, and sometimes a significant proportion, of subjects that lack detectable IgE antibody. Here we consider the relevance of IgE antibody responses for the development of a chemical respiratory allergy to diisocyanates. A case is made that IgE antibody responses are, either directly or indirectly, closely associated with occupational asthma to the diisocyanates (and to other chemical respiratory allergens). As such the argument is advanced here that IgE antibody represents an appropriate readout for the characterization of chemical respiratory allergens, and that uncertainty about mode of action should no longer represent a hurdle in the development of suitable test methods.

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Clinical and immunologic findings of methylene diphenyl diisocyanate‐induced occupational asthma in a car upholstery factory

Cited by 39 publications

References 38 publications

HLA CLASS II ALLELE AND IgG SENSITIZATION TO METHYLENE DIISOCYANATE IN EXPOSED WORKERS

HLA CLASS II ALLELE AND IgG SENSITIZATION TO METHYLENE DIISOCYANATE IN EXPOSED WORKERS

Histamine Release and Inflammatory Cell Infiltration in Airway Mucosa in Methylene Diphenyl Diisocyanate (MDI)-Induced Occupational Asthma

Diisocyanates, occupational asthma and IgE antibody: implications for hazard characterization

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