HLA CLASS II ALLELE AND IgG SENSITIZATION TO METHYLENE DIISOCYANATE IN EXPOSED WORKERS

Hur, Gyu Young; Lee, Kyung Wha; Lee, Hyun Young; Choi, Gil Soon; Park, Hae‐Sim; Ye, Young-Min

doi:10.1016/s1081-1206(10)60172-x

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…8,11 Recently, haplotypes including HLA-DRB1 , -DQB1 , and -DPB1 alleles were found to be associated with an increased risk of TDI asthma in Koreans. 12,13 Hur et al 14 also reported an association between a haplotype carrying the HLA-DRB1 , -DQB1 , and -DPB1 alleles and elevated serum-specific immunoglobulin G (IgG) levels in MDI-exposed workers.…”

mentioning

confidence: 99%

Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma

Yücesoy

Johnson

Lummus

et al. 2014

Journal of Occupational &Amp; Environmental Medicine

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Objective To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA). Methods The study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels. Results The HLA-E rs1573294 and HLA-DPB1 rs928976 SNPs were associated with an increased risk of DA under dominant (odds ratio [OR], 6.27; 95% confidence interval [CI], 2.37 to 16.6; OR, 2.79, 95% CI, 0.99 to 7.81, respectively) and recessive genetic models (OR, 6.27, 95% CI, 1.63 to 24.13; OR, 10.10, 95% CI, 3.16 to 32.33, respectively). The HLA-B rs1811197, HLA-DOA rs3128935, and HLA-DQA2 rs7773955 SNPs conferred an increased risk of DA in a dominant model (OR, 7.64, 95% CI, 2.25 to 26.00; OR, 19.69, 95% CI, 2.89 to 135.25; OR, 8.43, 95% CI, 3.03 to 23.48, respectively). Conclusion These results suggest that genetic variations within HLA genes play a role in DA risk.

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confidence: 99%

Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma

Yücesoy

Johnson

Lummus

et al. 2014

Journal of Occupational &Amp; Environmental Medicine

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“…On the other hand, the HLA haplotypes DRB1*15-DPB1*05, and HLA DRB1*1501-DQB1*0602-DPB1*0501 were reported as a susceptibility marker for the development of toluene diisocyanate-asthma in Koreans (Kim et al, 2006;Hur et al, 2009). In addition, an association was found between DRB1*0901-DQB1*0303-DPB1*0501 haplotype and the presence of serum-specific IgG in methylene diisocyanate-exposed workers (Hur et al, 2009).…”

Section: Occupational Asthmamentioning

confidence: 99%

Role of Genetic Factors in Pulmonary Disease Susceptibility

Yücesoy¹,

Johnson²,

Luster³

2015

Comparative Biology of the Normal Lung

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Biological and Genetic Markers in Occupational Asthma

Hur

Park

2014

Curr Allergy Asthma Rep

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Occupational asthma (OA) is a complex disease that is often hard to diagnose due to difficulties in detecting relevant exposure, along with inherent differences in disease susceptibility. Numerous studies have attempted to identify relevant biological and genetic markers for OA and to devise tools capable of detecting exposure to the causative agent. Immunological markers, including skin prick test reactivity and specific IgE and IgG antibodies can be used to detect high-molecular-weight allergens in cases of baker's asthma. For OA induced by low-molecular-weight agents, such as isocyanate, potential biomarkers include serum-specific IgE and IgG antibodies to isocyanate-HSA conjugate and IgG to cytokeratin 19 and transglutaminase-2. For protein-based markers, ferritin/transferrin and vitamin D-binding protein levels have been suggested for isocyanate-OA. Genetic markers of susceptibility to isocyanate-OA include human leukocyte antigen and CTNNA3. Further investigations will be needed to identify better biomarkers for OA, which may be used to inform clinical decision.

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HLA CLASS II ALLELE AND IgG SENSITIZATION TO METHYLENE DIISOCYANATE IN EXPOSED WORKERS

Cited by 6 publications

References 7 publications

Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma

Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma

Role of Genetic Factors in Pulmonary Disease Susceptibility

Biological and Genetic Markers in Occupational Asthma

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