Clinical and Genetic Risk Factors for Type 2 Diabetes at Early or Late Post Partum After Gestational Diabetes Mellitus

Kwak, Soo Heon; Choi, Sung Hee; Jung, Hye Seung; Cho, Young Min; Lim, Soo; Cho, Nam H.; Kim, Seong Yeon; Park, Kyong Soo; Jang, Hak Chul

doi:10.1210/jc.2012-3324

Cited by 97 publications

(95 citation statements)

References 39 publications

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“…The other representative study indicated a positive association of prepregnancy BMI with postpartum T2D risk (20). The present study with large sample size, long follow-up, and large incident cases of T2D and prediabetes during follow-up demonstrated that prepregnancy overweight and obesity had a hazardous effect on the risks of T2D and prediabetes among GDM women after delivery.…”

Section: Obesitysupporting

confidence: 43%

“…Until now, only two studies have assessed the association of prepregnancy BMI with the risk of postpartum T2D among prior GDM women (19,20). One study did not find any associations between prepregnancy BMI and T2D risk, The significance of the trend over different categories was tested in models with the median of each category as a continuous variable.…”

Section: Discussionmentioning

confidence: 99%

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Prepregnancy body mass index and weight change on postpartum diabetes risk among gestational diabetes women

Liu

Zhang

et al. 2014

Obesity

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Objective: To evaluate the effects of prepregnancy BMI and weight change from prepregnancy to postpartum on postpartum type 2 diabetes (T2D) risk among women with gestational diabetes (GDM). Methods: A retrospective cohort study in 1,263 GDM women at 1-5 years after delivery was performed. Cox proportional hazards regression models were used to evaluate the association of prepregnancy BMI and weight change with T2D and prediabetes risks. Results: The multivariable-adjusted hazard ratios based on different levels of prepregnancy BMI (<23, 23-24.9, 25-29.9, and 30 kg/m 2 ) were 1.00, 1.77, 2.35, and 6.54 (P trend < 0.001) for incident T2D, and 1.00, 1.46, 1.87, and 1.79 (P trend < 0.001) for incident prediabetes, respectively. Compared with women with stable weight (63 kg), those with weight gain 7 kg had an 86% and a 32% increased risk of diabetes and prediabetes, and those with weight loss 3 kg had a 45% decreased risk of prediabetes. The positive associations of prepregnancy BMI with incident diabetes and prediabetes risk were persistent in women with different levels of weight change (<3 kg and 3 kg). Conclusion: Prepregnancy obesity and excessive weight gain from prepregnancy to postpartum increase postpartum diabetes and prediabetes risks among GDM women.

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Section: Obesitysupporting

confidence: 43%

Section: Discussionmentioning

confidence: 99%

Prepregnancy body mass index and weight change on postpartum diabetes risk among gestational diabetes women

Liu

Zhang

et al. 2014

Obesity

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“…Our previous investigation has shown that women with Japanese GDM have beta cell dysfunction irrespective of presence or absence of overweight [25]. Regarding the genetic background, several studies revealed risk variants related to insulin secretion in Korean and Chinese population [36][37][38][39][40][41]. Of the three genetic variants found in this study, two are related to the regulation of insulin secretion (i.e.…”

Section: Discussionsupporting

confidence: 48%

“…Since women with GDM are at a high risk of future T2DM, genetic information on GDM would be useful for the T2DM risk classification [38,41]. Further research using a larger cohort is warranted for better understanding the genetics of GDM in Japanese women.…”

Section: Discussionmentioning

confidence: 99%

Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study

et al. 2017

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“…Currently, the pathogenesis of GDM is not clear, but GDM and T2D share several common risk factors and have a similar pathophysiology that includes glucose intolerance, insulin resistance, and impaired insulin secretion (Ryan et al, 2013). Additionally, women with a history of GDM are at an increased risk of GDM during subsequent pregnancies (Kwak et al, 2013). Several studies have shown that genetic factors play an important role in GDM occurrence (Zhang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Association between macrophage migration inhibitory factor rs1007888 and GDM

Zhan¹,

Li²,

Chen³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and the genetic susceptibility to gestational diabetes mellitus (GDM). A total of 240 GDM pregnant women (GDM group) and 330 healthy pregnant women (control group) were included in the study. Differences in the MIF rs1007888 genotype and allele frequencies and differences between fasting blood glucose, fasting insulin, homeostatic model assessment (HOMA)-insulin resistance, and HOMA-b levels of pregnant women with different genotypes were compared. MIF genotype distributions were significantly different in the GDM group compared to the control group (P < 0.05). No significant difference was observed in the allele distributions of MIF rs1007888 between the GDM group and control group (P > 0.05). GDM patients had higher fasting blood glucose, fasting insulin, and HOMA-insulin resistance levels, but lower HOMA-b levels than normal gestational women (P < 0.05). Fasting blood glucose, fasting insulin, and HOMA-insulin resistance in pregnant women with the GG genotype were significantly higher than those with GA and AA genotypes, while HOMA-b in pregnant women with the GG genotype was lower (all P < 0.05). Our findings demonstrated the associations among MIF polymorphism rs1007888, insulin resistance, and pancreatic β cell functions in GDM patients. The GG genotype of MIF rs1007888 may be a genetic susceptibility factor in the pathogenesis of GDM.

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Clinical and Genetic Risk Factors for Type 2 Diabetes at Early or Late Post Partum After Gestational Diabetes Mellitus

Abstract: Obesity was a risk factor for both early and late T2DM converters. However, early converters had more pronounced defects in β-cell function, which might be explained, in part, by differences in genetic predisposition.

Cited by 97 publications

References 39 publications

Prepregnancy body mass index and weight change on postpartum diabetes risk among gestational diabetes women

Prepregnancy body mass index and weight change on postpartum diabetes risk among gestational diabetes women

Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study

Association between macrophage migration inhibitory factor rs1007888 and GDM

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