Clinical and epidemiologic factors related to subsequent wheezing after virus-induced lower respiratory tract infections in hospitalized pediatric patients younger than 3 years

Takeyama, Aya; Hashimoto, Koichi; Sato, Masatoki; Sato, Toshiko; Tomita, Yoichi; Maeda, Ryo; Ito, Masaki; Katayose, Masahiko; Kawasaki, Yukihiko

doi:10.1007/s00431-014-2277-7

Cited by 37 publications

(35 citation statements)

References 44 publications

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“…HRVs are well-known causes of upper respiratory tract infections at all ages, occur throughout the year and are the principal cause of LRTI leading to hospitalisation in infants and young children outside of the winter RSV bronchiolitis season [74,78,[98][99][100][101][102][103][104][105]. While in older children HRVs appear to be the most important viruses in producing exacerbations of asthma [8,11,81,99], there is convincing evidence that they also cause LRTI and precipitate wheezing symptoms in infants and young children [100,101,106].…”

Section: Role Of Hrv In Wheezing/asthma Inception and Exacerbationmentioning

confidence: 99%

“…While in older children HRVs appear to be the most important viruses in producing exacerbations of asthma [8,11,81,99], there is convincing evidence that they also cause LRTI and precipitate wheezing symptoms in infants and young children [100,101,106]. In a study from Finland [102,103], using PCR-based tests, HRVs were isolated in 33% of the children hospitalised for wheezing and were the most prevalent respiratory virus identified from ⩾6 months of age, whereas the most common viral finding at <6 months of age was RSV.…”

Section: Role Of Hrv In Wheezing/asthma Inception and Exacerbationmentioning

confidence: 99%

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Infantile respiratory syncytial virus and human rhinovirus infections: respective role in inception and persistence of wheezing

2014

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There is evidence that respiratory viruses play a key role in the development and exacerbation of obstructive respiratory diseases in children. This review attempts to juxtapose the separate profiles and prototypes of pathogenenetic mechanisms represented by the two most common amongst such viruses: respiratory syncytial virus (RSV) and human rhinovirus (HRV).RSV represents the most common agent of severe airway disease in infants and young children, and is predominant in winter months. Large epidemiological studies have revealed an unequivocal relationship between RSV infection and subsequent wheezing into childhood, thought to be related to long-term changes in neuroimmune control of the airways rather than allergic sensitisation.HRV is a highly diverse group of viruses that affect subjects of all ages, is ubiquitous and occurs yearround. In contrast to RSV, infections with HRV cause minimal cytotoxicity but induce a rapid production of cytokines and chemokines with amplification of the inflammatory response. The susceptibility to HRVinduced bronchiolitis and subsequent wheezing appears to be linked to individual predisposition since it is often associated with a family or personal history of asthma/atopy.Thus, RSV probably serves as an "inducer" rather than a "trigger". Conversely, HRVs seem to serve as a "trigger" rather than an "inducer" in predisposed individuals. @ERSpublications Comprehensive overview of the different roles of RSV and HRV in the pathogenesis of recurrent wheezing in childhood

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Section: Role Of Hrv In Wheezing/asthma Inception and Exacerbationmentioning

confidence: 99%

Section: Role Of Hrv In Wheezing/asthma Inception and Exacerbationmentioning

confidence: 99%

Infantile respiratory syncytial virus and human rhinovirus infections: respective role in inception and persistence of wheezing

2014

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“…Acute respiratory infection is the main cause of recurrent wheezing in children. Respiratory viruses play a key role in the development and exacerbation of obstructive respiratory diseases in children (1,2). Recent studies showed that vitamin D acts as a hormone and takes a role in the function of many organs in addition to bone.…”

Section: Introductionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D levels in children with recurrent wheezing and relation to the phenotypes and frequency of wheezing

Doğru

Seren

2017

Eur Ann Allergy Clin Immunol

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Summary Background. Recurrent wheezing may be related to various reasons. There is a lack of knowledge about the effect of vitamin D status in the children with recurrent wheezing. The aim of this study is to compare the level of vitamin D between recurrent wheezing children and healthy controls, and to investigate the relationship between vitamin 21.66 ± 8.13 ng/mL (5.6-53) in the study group and 25.36 ± 10.17 ng/ mL (6-59) M. Dogru, L.P. Seren relative (mother, father, sibling) had allergic disease. Milk consumption of cases was not evaluated, because milk is not fortified with vitamin D in our country. The percentage of eosinophils, immunoglobulin (Ig) E levels and serum 25OHD levels were measured. RW patients were classified according to the number of wheezing episodes in the previous year as having had up to 3 episodes / year (n = 61) or > 3 episodes / year (n = 49). Excluding CriteriaPatients receiving multivitamin support or any systemic glucocorticoid therapy, patients with obesity (body mass index > 95.p), patients with the clinical findings of rickets (o-bain, x-bain etc.), with any (clinical or laboratory) history of congenital heart disease, chronic lung disease (such as cystic fibrosis, bronchiectasis), tuberculosis, bronchopulmonary dysplasia, immunodeficiency, neurologic or metabolic diseases were excluded.

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“…Among those viruses, HRV-C rather than the other HRV subtypes or HRSV, which was detected in the nasopharynx of healthy children during ARI accompanied by wheezing symptoms, was positively associated with later chronic wheezing among all children and particularly for those who were atopic by 2 years (6). In a recent study, HRSV-and HRV-induced lower respiratory tract infections in 412 pediatric patients up to the age of 3 years were associated with the development of wheezing and exacerbations (7). In addition, pediatric patients with HRV-induced wheezing were more likely to develop a subsequent recurrent wheezing and asthma during the following 3 years (7).…”

Section: The Prevalence Of Viruses In the Airwaysmentioning

confidence: 94%

Viruses and bacteria in Th2‐biased allergic airway disease

Feng

Zhang

Gevaert

et al. 2016

Allergy

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Allergic airway diseases are typically characterized by a type 2-biased inflammation. Multiple distinct viruses and bacteria have been detected in the airways. Recently, it has been confirmed that the microbiome of allergic individuals differs from that of healthy subjects, showing a close relationship with the type 2 response in allergic airway disease. In this review, we summarize the recent findings on the prevalence of viruses and bacteria in type 2-biased airway diseases and on the mechanisms employed by viruses and bacteria in propagating type 2 responses. The understanding of the microbial composition and postinfectious immune programming is critical for the reconstruction of the normal microflora and immune status in allergic airway diseases.

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Clinical and epidemiologic factors related to subsequent wheezing after virus-induced lower respiratory tract infections in hospitalized pediatric patients younger than 3 years

Abstract: RSV and RV infections are factors in the development and exacerbation of wheezing after virus-induced lower respiratory tract infections. Moreover, RV-induced wheezing may be associated with subsequent recurrent wheezing and the development of asthma.

Cited by 37 publications

References 44 publications

Infantile respiratory syncytial virus and human rhinovirus infections: respective role in inception and persistence of wheezing

Infantile respiratory syncytial virus and human rhinovirus infections: respective role in inception and persistence of wheezing

Serum 25-hydroxyvitamin D levels in children with recurrent wheezing and relation to the phenotypes and frequency of wheezing

Viruses and bacteria in Th2‐biased allergic airway disease

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