Serum 25-hydroxyvitamin D levels in children with recurrent wheezing and relation to the phenotypes and frequency of wheezing

Doğru, Mahmut; Seren, LP

doi:10.23822/eurannaci.1764-1489.14

Cited by 9 publications

(7 citation statements)

References 17 publications

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“…Vitamin D level is significantly lower in children with recurrent wheeze than control group as well as vitamin D status as severe deficiency, deficiency, and insufficiency significantly recorded in children with recurrent wheeze. This is in consistent to a study carried out by Dogru, etal 26 and in Sweden by Stenberg et al 27 who shows that preschool children admitted to hospital with acute wheeze had significantly lower levels of vitamin D than children with no wheeze in an age-matched control group. In the current study the mean serum calcium, phosphorus and alkaline phosphatase levels shows no statistically significant difference between patients and control group.…”

Section: Discussionsupporting

confidence: 91%

Vitamin D Status in Children with Recurrent Wheeze

Habib¹,

Salman²

2020

MJBU

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Background: it has been shown that low serum 25-hydroxyvitamin D concentration was associated with a higher risk of upper and lower respiratory infections in children Aim to evaluate vitamin D concentration and selected biochemical markers in infants and children with recurrent wheeze. Methods: a case-control study has been carried out to measure serum vitamin Concentration; on 33 patients with recurrent wheeze, their ages ranged from 4-60 months; over the period from the1 st of March 2014 to the end of June 2014. Forty-two age and sex matched healthy children were selected as control group. List of investigation was measured by spectrophotometer as serum calcium, phosphorus, alkaline phosphatase and 25-OH vitamin. Result: Frequency of breast feeding in the first two years of life was low in wheezy children and significantly shorter duration of breast feeding less than 4 months in wheezy children than control group, P value 0.01. Vitamin D concentration was significantly low in children with recurrent wheeze than the control group; (21.69 ng/ml, 39.36 ng/ml) respectively with p-value 0.000. The severity of vitamin D deficiency was significant in children with recurrent wheeze, severe deficiency of vitamin D < 5 ng/ml recorded in 4(100%), p-value of 0.001.while mean serum calcium, phosphorus and alkaline phosphatase shows no significant difference. There is no significant relation observed between mean Vitamin D concentration and selected variables of infants and children with wheeze (P value > 0.05) Conclusion: vitamin D supplementation may be considered in infants and children with recurrent wheeze.

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Section: Discussionsupporting

confidence: 91%

Vitamin D Status in Children with Recurrent Wheeze

Habib¹,

Salman²

2020

MJBU

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“…Vitamin D reportedly reduces eosinophilic airway inflammation in murine lung tissue [ 40 ] and sputum from asthma patients [ 41 ]. Even though the literature reports a positive correlation between sputum and serum eosinophilia [ 42 ], several articles mention that vitamin D supplements and serum 25-OH-VitD status do not seem to significantly influence serum eosinophils [ 18 , 43 ], similar to the finding reported in the current study. Our results can be explained by the fact that the link between the eosinophil count and serum 25-OH-VitD was only evaluated once, at the moment that the patient was included in the study, therefore offering only a snapshot of the inflammation, whereas monitoring the dynamics of the serum levels of both might yield a more accurate reflection of the evolution of inflammation during oral vitamin D 3 therapy [ 29 ].…”

Section: Discussionsupporting

confidence: 87%

Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing

Adam-Bonci

Cherecheş-Panţa

Bonci

et al. 2020

IJERPH

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Even though vitamin D is widely acknowledged as having a potential immunomodulatory role in asthma, its exact beneficial mechanisms are yet to be clarified. An optimal serum 25-hydroxy-vitamin D (25-OH-VitD) level in pediatric asthma patients might not rely solely on the effect of dose-dependent vitamin D3 intake, but might also be influenced by factors related to insufficient asthma control. We aimed to survey the prevalence of serum 25-OH-VitD deficiency and analyze whether suboptimal levels were associated with asthma severity factors. The current cross-sectional study enrolled 131 pediatric asthma or asthma-suggestive recurrent wheezing patients, for whom serum 25-OH-VitD, IgE, and eosinophil count were assessed. The prevalence of suboptimal serum 25-OH-VitD was 58.8%. A suboptimal vitamin D status was associated with asthma exacerbation in the previous month (p = 0.02). Even under seasonal oral vitamin D3 supplementation, patients with a positive history of asthma attack in the previous four weeks presented significantly lower serum 25-OH-VitD concentrations, compared to their peers with no disease exacerbation. In conclusion, sequential measurements of serum 25-OH-VitD might prove useful for future studies evaluating the dynamic changes in vitamin D3 status in regard to asthma, especially in symptomatic patients.

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“…In addition, in many studies it has been reported that low levels of vitamin D may be a risk factor for recurrent wheezing. 22,23 Similarly, we found significantly lower vitamin D levels in children with recurrent wheezing compared to the control group.…”

Section: Discussionsupporting

confidence: 60%

Evaluation of serum/salivary levels of carnosine and cotinine in recurrent wheezing of young children with passive smoking

Kılıç¹,

Alataş²,

Taşkın³

et al. 2021

Turk J Pediatr

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Background. Recurrent wheezing is common in young children, with a cumulative prevalence of up to 40 % in the first 6 years of life. In this study, we aimed to evaluate the relationship between the number of wheezing episodes and the number of cigarettes smoked at home and serum / saliva cotinine and carnosine levels in children with recurrent wheezing.Methods. This study was conducted with 80 young children with recurrent wheezing, aged between 1-4 years and 50 healthy control groups. Patient population was divided into three groups depending on the number of their exposure to cigarette smoke and wheezing attacks. Serum cotinine, saliva cotinine, serum carnosine, saliva carnosine, vitamin D levels were measured by using the ELISA method.Results. A significant relationship for serum cotinine and saliva cotinine levels was found between groups (p<0.05). It was determined that as the number of exposure to cigarette smoke and number of wheezing episodes in young children with recurrent wheezing increased, the level of serum/saliva cotinine levels increased significantly, compared to the control group. In contrast, it was determined that as the number of exposure to cigarette smoke and number of wheezing episodes in young children with recurrent wheezing increased, serum/saliva carnosine levels decreased significantly, compared to the control group. In addition, a significant difference in serum vitamin D levels was found between healthy young children and young children with recurrent wheezing (p<0.05). Conclusions.We think that the measurement of salivary cotinine is a useful and noninvasive marker to evaluate passive smoking exposure in the etiology of recurrent wheezing in young children.

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Serum 25-hydroxyvitamin D levels in children with recurrent wheezing and relation to the phenotypes and frequency of wheezing

Cited by 9 publications

References 17 publications

Vitamin D Status in Children with Recurrent Wheeze

Vitamin D Status in Children with Recurrent Wheeze

Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing

Evaluation of serum/salivary levels of carnosine and cotinine in recurrent wheezing of young children with passive smoking

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