Clinic and Prognosis of Rheumatoid Arthritis in Children

Edstöm, G.; Gedda, Per Olof

doi:10.3109/rhe1.1957.3.issue-1-4.18

Cited by 36 publications

(3 citation statements)

References 23 publications

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“…Both sexes contribute equally to the second peak. Other authors have provided sex-specific ages of onset in JRA, but the numbers of patients in these reports have been too small to analyze (14,15). T h e data of Ansell and Bywaters suggest a peak incidence for boys between 2 and 4 years with a subsequent gradual increase in occurrence from 9 to 15 years (9).…”

Section: Discussionmentioning

confidence: 99%

Pathogenic implications of age of onset in juvenile rheumatoid arthritis

Sullivan

Cassidy

Petty

1975

Arthritis & Rheumatism

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An analysis of age of onset in juvenile rheumatoid arthritis was performed in the last 300 children seen in our clinic. There was a peak age of onset in girls at 1 to 3 years. Distribution of age of onset in boys was bimodal with the first peak at 2 years of age and the second at 9 years. There was no accentuation of frequency in either sex in the 10‐ to 14‐year age group. The distribution of age of onset was bimodal in both monarticular and polyarticular onset of disease, but no particular modal age of onset was seen with systemic onset of disease. It is possible that these data reflect that JRA is not a homogeneous disease, or that there are age‐sex related differences in host susceptibility or pathogenoc agents.

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Section: Discussionmentioning

confidence: 99%

Pathogenic implications of age of onset in juvenile rheumatoid arthritis

Sullivan

Cassidy

Petty

1975

Arthritis & Rheumatism

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“…This is something new: amyloidosis was practically unknown in the rare [8,9] follow-up studies in the period before antibiotics, vaccination or cortisone: even without biopsy, the characteristic clinical features of amyloidosis should not have been overlooked. This is something new: amyloidosis was practically unknown in the rare [8,9] follow-up studies in the period before antibiotics, vaccination or cortisone: even without biopsy, the characteristic clinical features of amyloidosis should not have been overlooked.…”

Section: Amyloidosismentioning

confidence: 99%

Prognosis in juvenile chronic arthritis

Stoeber

1981

Eur J Pediatr

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A total of 433 children, hospitalized in the Rheumatic Children's Hospital Garmisch-Partenkirchen, were followed on average for 15 years (range 10-22 years) after the onset of definite juvenile chronic arthritis. This paper reveals clearly that the different subgroups of chronic rheumatic disease in childhood with their different complications have a definite relationship to prognosis. Severe limitation with inability to attend normal school or employment occurred in 13.4% of children with systemic polyarticular arthritis (Still's syndrome) and 11.4% of the non-systemic cases, but not in the pauci-articular group. In the latter group 82.5% of the children remained without disability or with only slight impairment: this is significantly better than in the systemic or non-systemic polyarticular groups. Although the high incidence of chronic rheumatic iridocyclitis is common in children with pauci-articular arthritis, none of this group had been handicapped by severe eye complications or blindness, in contrast to several early cases with systemic or non-systemic polyarthritis. This might be due to regular eye checks in the pauci-articular group. Of the children in the systemic polyarticular group 10% were dwarfed. Mortality in the systemic group was 13.8%, in contrast to 1% in the non-systemic polyarticular and 0% in the pauci-articular arthritis group. Secondary amyloidosis was the most important cause of death, mainly in systemic cases. Of the children whose amyloidosis had been verified, 44% died in their second or third decades, mostly with uraemia.

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“…It appears that an allergic-toxic mechanism can also be implicated in arthralgias which occur in some cases of anaphylactoid purpura and in the arthritis, which is one of the extraintestinal manifestations of ulcerative colitis. undramatic picture to a fullblown, sepsis-like condition, represented by the syndrome of Still and Wissler's "subsepsis allergica" (28, 30, 33, 34), have been confirmed in several recent reports (8,9,17,22,25,29). It is generally agreed that most cases in children show certain common trends when compared to adults with the disease.…”

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confidence: 76%

The Diagnosis and Course of Rheumatoid Arthritis and Benign Aseptic Arthritis in Children1

Hellström

1961

Acta Paediatrica

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Summary Diagnostic criteria for rheumatoid arthritis adapted for the features of the disease in children have been suggested and used for a classification in a follow‐up examination. This study comprised 87 cases of aseptic arthritis of at least three weeks duration hospitalized in pediatric departments in Stockholm during 1952–1957. Those not fulfilling the criteria were labelled benign aseptic arthritis. They were compared with the rheumatoid arthritis cases as to the early clinical picture and the prognosis. The entirely different course in the two groups indicates that the suggested classification is of value in the prognostic prediction in cases of aseptic arthritis in children.

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Clinic and Prognosis of Rheumatoid Arthritis in Children

Cited by 36 publications

References 23 publications

Pathogenic implications of age of onset in juvenile rheumatoid arthritis

Pathogenic implications of age of onset in juvenile rheumatoid arthritis

Prognosis in juvenile chronic arthritis

The Diagnosis and Course of Rheumatoid Arthritis and Benign Aseptic Arthritis in Children1

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