Pathogenic implications of age of onset in juvenile rheumatoid arthritis

Sullivan, Donita B.; Cassidy, James T.; Petty, Ross E.

doi:10.1002/art.1780180309

Cited by 71 publications

(21 citation statements)

References 12 publications

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“…The estimate for JRA was somewhat higher than that reported from Michigan, 9.2 per 100,000 for children <16 years old (30). The 4 children with JRA were in remission at the time of the study.…”

Section: Resultscontrasting

confidence: 58%

Rheumatic diseases in an inuit population

Oen

Postl

Chalmers

et al. 1986

Arthritis & Rheumatism

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Prevalence and incidence rates for rheumatic diseases were found to be minimal among the Inuit people in the Keewatin District of the Northwest Territories, Canada. Patient identification was achieved by a review of medical records. All identified patients were interviewed and examined by a participating rheumatologist. Among women, the prevalence of rheumatoid arthritis, adjusted for age of the Manitoba population, was 1,822 per 100,000 and was comparable with that observed in other populations; no cases of rheumatoid arthritis in men were confirmed. The age-adjusted prevalence of osteoarthritis, 1,219 per 100,000 in men and 2,144 per 100,000 in women, was apparently low. A moderately high incidence of Reiter's syndrome, 24.9 per 100,000, was found. The findings in children suggested a high frequency of seronegative spondylarthropathies (yearly incidence 60.1 per 100,000), although the adjusted yearly incidence for juvenile rheumatoid arthritis also appeared to be high, 23.6 per 100,000. The frequencies of HLA antigens in patient groups were compared with those found in 19 patients with musculoskeletal complaints but no rheumatic disease. Both HLA-B27 and HLA-DR4 appeared to be common in these controls, 36.8% and 63.2%, respectively. Nevertheless, there was a higher frequency of HLA-B27 in patients with seronegative spondylarthropathies (87%) than in controls (P = 0.001). Because of the small numbers of patients who had rheumatoid arthritis, no associations with HLA were made for this condition. Although the findings suggest differences in the distribution of rheumatic diseases compared with those found in other populations, more complete studies are required to confirm these observations.

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Section: Resultscontrasting

confidence: 58%

Rheumatic diseases in an inuit population

Oen

Postl

Chalmers

et al. 1986

Arthritis & Rheumatism

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“…Very similar general patterns of onset have been observed within JRA, with a peak around age 2 -3 years composed predominantly of girls and a second distribution through mid-and late-childhood where the gender distribution is somewhat more balanced (Sullivan et al 1975;Murray et al 1999). Analysis of HLA expression has also reflected a striking variation in allele frequency with age of onset, occasionally in a gender-specific fashion and commonly with a suggestion of an inflection point around age 5 -6 years (Murray et al 1999).…”

supporting

confidence: 59%

Subpopulations Within Juvenile Psoriatic Arthritis: A Review of the Literature

Stoll

Nigrović

2006

Journal of Immunology Research

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The presentation of juvenile psoriatic arthritis (JPsA) has long been recognized to be clinically heterogeneous. As the definition of JPsA expanded to accommodate atypical manifestations of psoriasis in young children, studies began to reflect an increasingly clear biphasic distribution of age of onset, with peaks in the first few years of life and again in early adolescence. These two subpopulations differ in gender ratio, pattern of joint involvement, laboratory findings and potentially response to therapy. Intriguingly, a similar distribution of age of onset has been observed in juvenile rheumatoid arthritis (JRA), and correlates with patterns of HLA association. While a secure classification of subpopulations within JPsA awaits improved pathophysiologic understanding, future research must consider the possibility that different disease mechanisms may be operative in distinct subsets of patients with this disorder.

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“…1) shows a bimodal curve with an early peak occurring around the age of 3 years affecting mainly females and a late, smaller and wider peak occurring at the end of the first decade of life affecting both males and females in equal proportion [8]. This dis tribution pattern is similar to that reported originally by Sullivan et al [8] for children with JRA in the United States.…”

Section: Discussionsupporting

confidence: 81%

Pattern of Juvenile Rheumatoid Arthritis in a Teaching Hospital in Kuwait

Alsaeid¹,

Alonaizi²

1997

Med Principles Pract

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Reports on juvenile rheumatoid arthritis (JRA) from developing countries are scarce due to lack of comprehensive epidemiologic surveys. We report our experience with this disease in Kuwait. This study involves 47 children diagnosed with JRA over a period of 3 years. All 47 children satisfied the American College of Rheumatology criteria for the diagnosis of JRA. The results revealed a prevalence of 0.36 cases per 1,000 children at risk, a rate compatible with international figures. Pauciarticular onset, the predominant subtype, accounted for 49% while polyarticular and systemic onset type accounted for 25.5% each. Iridocyclitis was diagnosed in 3 children (6.4%) with positive antinuclear antibody. Although the prevalence of JRA and its subtypes is not different from figures reported for other regions, iridocyclitis appears to be infrequent in the population of Kuwait.

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Pathogenic implications of age of onset in juvenile rheumatoid arthritis

Cited by 71 publications

References 12 publications

Rheumatic diseases in an inuit population

Rheumatic diseases in an inuit population

Subpopulations Within Juvenile Psoriatic Arthritis: A Review of the Literature

Pattern of Juvenile Rheumatoid Arthritis in a Teaching Hospital in Kuwait

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