Climate drivers of hospitalizations for mycoses in Brazil

Silva, Fabrício Brito; Santos, Jessflan Rafael Nascimento; Silva, Letícia Chagas da; Gomes, Wolia Costa; Villis, Paulo Cesar Mendes; Gomes, Eliane dos Santos; Pinheiro, Edilene de Araújo Diniz; Azevedo, Conceição de Maria Pedrozo e Silva de; Días, Rosane da Silva; Monteiro, Cristina de Andrade; Santos, Julliana Ribeiro Alves

doi:10.1038/s41598-019-43353-w

Cited by 12 publications

(16 citation statements)

References 31 publications

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“…In this study, we observed that hospitalisations for mycoses have a seasonal cycle accompanied by climate variables, such as precipitation and maximum and minimum temperature . In addition to socio‐economic susceptibility, the seasonality of hospitalisations for mycoses was also found to represent an indicator of environmental vulnerability.…”

Section: Discussionmentioning

confidence: 84%

“…In addition to socio‐economic susceptibility, the seasonality of hospitalisations for mycoses was also found to represent an indicator of environmental vulnerability. In addition, the minimum temperature, influenced by La Niña, was the key climatic variable in periods with high prevalence of HM …”

Section: Discussionmentioning

confidence: 99%

“…33 Our data support several studies that affirm the strong influence of rain on the incidence of mycoses. 6,7,14,30,31,34,35 Climatic variables, such as precipitation and temperature, are known to affect the incidence of coccidioidomycosis. 34 The distribution of…”

Section: Discussionmentioning

confidence: 99%

“…The relationships between climate and epidemiological events as well as the prevalence of diseases and Pacific interdecadal climate oscillation have been described in some studies . Recently, evidence of the impact of climate on hospitalisations for mycoses in Brazilian state capitals was highlighted in a study performed by our group . However, studies evaluating the impact of climate on the incidence of mycoses in Brazil are restricted to the South‐East region of the country, a region that provides enough funding for scientific research, in contrast to the north‐east region with few resources available for development of studies…”

Section: Introductionmentioning

confidence: 99%

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Hospitalisations for mycoses as an indicator of socio‐environmental vulnerability in the Brazilian Amazon‐Savanna transition region

Silva

Oliveira

Silva

et al. 2019

Mycoses

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Background The infections caused by fungi represent a global concern and an important cause of hospital admissions in endemic areas. The influence of socio‐environmental factors in infectious diseases has been documented; however, this phenomenon remains unclear regarding mycoses. Objectives This study aimed to analyse the spatio‐temporal dynamics of hospitalisations for mycoses (HM) and the association with socio‐economic and climate data in the Amazon‐Savanna Transition Region in the state of Maranhão, Brazil. Methods In this study, Spearman's correlation was applied to determine the correlation between HM, socio‐economic and climatic data obtained from national databases in the period from 1998 to 2016. Hospitalisations for mycoses data were spatialised and analysed using the local Moran's index. Results Our data revealed a negative and significant correlation between HM and socio‐economic data regarding population, demographic density, human development index, health facilities and sanitary sewage. Significant correlations were observed between HM and precipitation, maximum temperature and minimum temperature. The main modulating climatic variable was the minimum temperature. The spatial autocorrelation analysis showed the dynamics of HM in municipalities belonging to the different regions of the state influenced by socio‐economic conditions. We observed the presence of municipalities with high incidence of HM surrounded by others with low HM cases and vice versa. Conclusions Our results indicate that hospitalisations for mycoses represent an important indicator of socio‐environmental vulnerability in the Amazon‐Savanna transition region in Brazil. We encourage the adoption of measures to mitigate social and environmental impact on these diseases, especially in municipalities with low socio‐economic status.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hospitalisations for mycoses as an indicator of socio‐environmental vulnerability in the Brazilian Amazon‐Savanna transition region

Silva

Oliveira

Silva

et al. 2019

Mycoses

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“…Besides the clinical importance of fungal infections caused by theses pathogenic yeasts, interestingly, climatic abnormalities due to phenomena such as La Niña and El Niño have recently been described as important in the distribution and occurrence of mycoses in countries influenced by them [59].…”

Section: Pathogenic Yeast Infections: a Serious Health Problemmentioning

confidence: 99%

Phytochemicals and Their Antifungal Potential against Pathogenic Yeasts

Monteiro¹,

Santos²

2020

Phytochemicals in Human Health

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The rate of fungal infections is increasing rapidly, and pathogenesis of their species is poorly understood. Among fungi, Candida species are a major cause of morbidity and mortality worldwide and thus represent a serious threat to public health. In addition, Cryptococcus spp. are yeasts responsible for serious lung infections and meningitis. Polyenes, fluoropyrimidines, echinocandins, and azoles are used as commercial antifungal agents to treat fungal infections. However, the presence of intrinsic and developed resistance against azole antifungals has been extensively documented. The re-emergence of classical fungal diseases has occurred because of the increment of the antifungal resistance phenomenon. In this way, the development of new satisfactory therapy for fungal diseases persists as a major challenge of present-day medicine. The urgent need includes the development of alternative drugs that are more efficient and tolerant than those traditional already in use. The identification of new substances with potential antifungal effect at low concentrations or in combination is also a possibility. This chapter briefly examines the infections caused by Candida and Cryptococcus species and focuses on describing some of the promising alternative molecules and/or substances that could be used as antifungal agents, their mechanisms of action, and their use in combination with traditional drugs.

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