Climate change imprints on soil are projected primarily through the changes in soil moisture and surge in soil temperature and CO2 levels in response to climate change and is anticipated to have varying impacts on soil characteristics and processes that are instrumental in the restoration of soil fertility as well as productivity. Climate change encompasses a major concern of sharing its impact on the stability and functionality of soil microbiome and is characterized by one or more chief stability metrics encircling resistance, resilience, and functional redundancy. Nevertheless, the explorations over the past years have unveiled the potential of microbial interventions in the regeneration of soils or assurance of perked-up resilience to crops. The strategies involved therein encompass harnessing the native capability of soil microbes for carbon sequestration, phyto-stimulation, bio fertilization, rhizo-mediation, biocontrol of plant pathogens, enzyme-mediated breakdown, antibiosis, prompting of anti-oxidative defense mechanism, exudation of volatile organic compounds (VOCs) and induced systemic resistance (ISR) response in the host plant. However, the short storage and shelf-life of microbe-based formulations stay a significant constraint and rigorous efforts are necessary to appraise their additive impact on crop growth under changing climate scenarios.