The western U.S. is expected to experience more frequent and severe droughts as a result of climate change, with potentially large impacts on agricultural production and the economy. Irrigated farmers have multiple options for minimizing the impact of drought including switching to more efficient irrigation technologies. More efficient technologies that increase the fraction of the water available to the crop root zone would allow farmers to maintain current production levels with less water. However, these systems are capital intensive. The objective of this study is to explore when (and under what climatic conditions) it makes economic sense for farmers to invest in new irrigation systems. We examine this in the Yakima River Basin in Washington State of the U.S. We use VIC‐CropSyst, a large‐scale grid‐based modeling framework that mechanistically simulates hydrologic and agricultural processes. Water supply simulated by VIC‐CropSyst drives a river system and water management model (YAK‐RW). A computational platform was developed to perform the economic analysis for each grid cell, crop type, and future climate scenario separately, which allowed us to explore whether the implementation of more efficient irrigation systems would be economically viable. Our results indicate that investing in a more efficient irrigation system improves agricultural economy of the Yakima River Basin (9% −25%). We also show that at the farm level, more significant droughts can provide economic incentives for investment up to a point. For severe climate change projections, droughts become frequent and severe enough that economic benefits of improving water use efficiency do not exceed investment costs.