Climate change and its impact on allergic rhinitis and other allergic respiratory diseases

Lin, Guojian; Zacharek, Mark A.

doi:10.1097/moo.0b013e3283524b14

Cited by 15 publications

(8 citation statements)

References 34 publications

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“…7 Intermittent and persistent rhinitis are not synonymous with seasonal and perennial rhinitis and may be differentially associated with risk factors. 8 Studies that assess how climatic factors may influence these 2 types of rhinitis and associated diseases are of interest 9 and may provide indications as to the potential effects of future climate change.…”

Section: Introductionmentioning

confidence: 99%

Childhood intermittent and persistent rhinitis prevalence and climate and vegetation: a global ecologic analysis

Fuertes

Butland

Anderson

et al. 2014

Annals of Allergy, Asthma & Immunology

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Section: Introductionmentioning

confidence: 99%

Childhood intermittent and persistent rhinitis prevalence and climate and vegetation: a global ecologic analysis

Fuertes

Butland

Anderson

et al. 2014

Annals of Allergy, Asthma & Immunology

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“…In our current in-season trial, exposure of each subject to grass pollen occurred in a natural and obviously non-controlled manner, and allergen doses might have varied considerably over time as well as within the whole study population. In addition to pollen counts, the country in which the study was performed, as well as other environmental factors such as climate and air pollution could also influence the results of a trial conducted during the pollen season [ 15 , 16 ].…”

Section: Resultsmentioning

confidence: 99%

Oral administration of Lactobacillus paracasei NCC 2461 for the modulation of grass pollen allergic rhinitis: a randomized, placebo‐controlled study during the pollen season

Nembrini

Singh

Castro

et al. 2015

Clinical & Translational All

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BackgroundThe efficacy of Lactobacillus paracasei NCC 2461 in modulating allergic rhinitis was previously evaluated in two exploratory clinical studies. Oral administration with NCC 2461 reduced specific subjective symptoms following nasal provocation tests with controlled grass pollen allergen concentrations. Our aim was to confirm the anti-allergic effect of NCC 2461 in grass pollen allergic subjects exposed to natural doses of allergens during the pollen season.FindingsA double-blind, randomized, placebo-controlled, parallel study was conducted with 131 grass pollen allergic subjects from May to July 2012 in concomitance with the pollen season in Berlin. NCC 2461 or placebo was administered daily for an 8-week period to adult subjects with clinical history of allergic rhinitis to grass pollen, positive skin prick test and IgE to grass pollen. During the 8 weeks, symptoms and quality of life questionnaires were filled out, and plasma was collected for IgE analysis at screening and at the end of the intervention. All subjects were included within a 5-day interval, ensuring exposure to similar air pollen counts for each individual during the trial period. The results obtained show that symptoms increased with pollen loads, confirming a natural exposure to the allergen and presence of pollen-induced allergic rhinitis in the subjects. However, no significant differences were observed in allergic rhinitis symptoms scores, quality of life, or specific IgE levels between subjects receiving NCC 2461 as compared to placebo administration.ConclusionIn contrast to previous findings, oral administration of NCC 2461 did not show a beneficial effect on allergic rhinitis in a field trial. The influence of study design, allergen exposure and intervention window on the efficacy of NCC 2461 in modulating respiratory allergy should be further evaluated.Electronic supplementary materialThe online version of this article (doi:10.1186/s13601-015-0085-4) contains supplementary material, which is available to authorized users.

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“…However, recent environmental changes (global warming and increased CO 2 concentrations) have changed the concentration of major allergens in pollens such as Amb a 1 and Bet v 1 (10) and the allergenic components of major pollens (11,12) that could influence clinical outcomes. The 2012 Korean pollen calendar demonstrated that allergenic flowers blossom earlier and fall later compared to previous nationwide surveys from 1997 to 2002, which contributed to increased pollinosis over the last 10 yr (1, 11, 12, 13, 14, 15, 16). In addition, increased allergenic potency with environmental change was noted in Japanese Hop pollens presented as the intensification of the major allergenic component at 10 kDa and the development of new sensitization to additional IgE binding components (12).…”

mentioning

confidence: 91%

“…Our previous study demonstrated that environmental changes over the last 10 yr could induce the intensification of major allergenic component of Japanese hop pollen at 10 kDa and a new generation of additional IgE binding components within the pollens. The findings suggest that climate change can increase the allergenic potency of major pollens through intensification or the generation of new IgE binding components within major tree or weed pollens (alder, birch, ragweed and mugwort pollens) that can contribute to the increased prevalence and severity of pollinosis in Korea (10, 11, 12, 13, 14, 15, 20). The present study demonstrates that sIgE levels to offending allergens did not decrease; conversely, the results indicated a paradoxical increase in IgE binding components to alder, birch, ragweed and mugwort pollens after allergen-SIT in a subpopulation of pollinosis patients that could reduce clinical outcomes of SIT.…”

mentioning

confidence: 99%

Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients

et al. 2014

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Allergen-specific immunotherapy (SIT) reduces allergen specific IgE (sIgE) levels and achieves clinical and immunological tolerance by modulating innate and adaptive immunological responses. Increased temperature and CO2 concentrations caused by climate changes contribute to an increase of pollen count and allergenicity that influences clinical SIT outcomes. In this study, we investigated the changes of IgE binding components to tree and weed pollens in pollinosis patients who showed a paradoxical increase of serum sIgE level during pollen-SIT. We enrolled nine patients who showed an increasing pattern of serum sIgE level to alder, birch, ragweed and mugwort pollens by enzyme-linked immunosorbant assay. IgE immunoblot analysis confirmed the intensification or new generation of major IgE binding components that could be induced by climate change. The findings suggest that the regular monitoring of sIgE levels and symptom changes is required to improve the clinical outcomes of SIT in patients undergoing SIT for tree and weed pollens.Graphical Abstract

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Climate change and its impact on allergic rhinitis and other allergic respiratory diseases

Cited by 15 publications

References 34 publications

Childhood intermittent and persistent rhinitis prevalence and climate and vegetation: a global ecologic analysis

Childhood intermittent and persistent rhinitis prevalence and climate and vegetation: a global ecologic analysis

Oral administration of Lactobacillus paracasei NCC 2461 for the modulation of grass pollen allergic rhinitis: a randomized, placebo‐controlled study during the pollen season

Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients

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