Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients

Kim, Mi Ae; Yoon, Moon-Gyung; Jin, Hongzhe; Shin, Yoo-Seob; Park, Hae‐Sim

doi:10.3346/jkms.2014.29.7.1025

Cited by 3 publications

(2 citation statements)

References 20 publications

(39 reference statements)

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“…Interestingly, an increase in specific IgE has recently been observed in patients with allergy to pollens (including allergy to ragweed) despite a few years of AIT maintenance with corresponding allergen extracts. The authors interpret this paradoxical increase in sIgE on the basis of environmental changes which can increase the allergenic potency of major allergens in pollens such as ragweed 32 .…”

Section: Methodsmentioning

confidence: 99%

Ragweed pollen concentration predicts seasonal rhino-conjunctivitis and asthma severity in patients allergic to ragweed

Bonini

Monti

Pelagatti

et al. 2022

Sci Rep

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In this work, we investigate the correlation between ragweed pollen concentration and conjunctival, nasal, and asthma symptom severity in patients allergic to ragweed pollen using ambient pollen exposure in the Milan area during the 2014 ragweed season We calculate the pollen/symptom thresholds and we assess the effectiveness of ragweed allergen immunotherapy (AIT). A total of 66 participants allergic to ragweed (Amb a 1) were enrolled in the study and divided into two groups: AIT treated (24) and no AIT treated (42). Pollen counts and daily symptom/medication patient diaries were kept. Autoregressive distributed lag models were used to develop predictive models of daily symptoms and evaluate the short-term effects of temporal variations in pollen concentration on the onset of symptoms. We found significant correlations between ragweed pollen load and the intensity of symptoms for all three symptom categories, both in no AIT treated (τ = 0.341, 0.352, and 0.721; and ρ = 0.48, 0.432, and 0.881; p-value < 0.001) and in AIT treated patients ($$\tau$$ τ = 0.46, 0.610, and 0.66; and ρ = 0.692, 0.805, and 0.824; p-value < 0.001). In both groups, we observed a positive correlation between the number of symptoms reported and drug use. Mean symptom levels were significantly higher in no AIT treated than in AIT treated patients (p-value < 0.001) for all symptom categories. Pollen concentration thresholds for the four symptom severity levels (low, medium–low, medium–high and high) were calculated. Ragweed pollen concentration is predictive of symptom severity in patients with a ragweed (Amb a 1) allergy. Patients treated with AIT had significantly reduced mean symptom levels compared to those without AIT.

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Section: Methodsmentioning

confidence: 99%

Ragweed pollen concentration predicts seasonal rhino-conjunctivitis and asthma severity in patients allergic to ragweed

Bonini

Monti

Pelagatti

et al. 2022

Sci Rep

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“…In contrast to the international and national studies described above is the small-scale clinical study by Kim et al [47]. The study explored the clinical outcomes of allergenspecific immunotherapy in the context of climate change.…”

Section: Allergic Diseasesmentioning

confidence: 99%

Environmental Allergens: from Asthma to Hay Fever and Beyond

Beggs

2015

Curr Clim Change Rep

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Climate change has many impacts on environmental allergens and allergic diseases such as asthma and hay fever. Our knowledge of these impacts has grown considerably over the last 2 decades or so, and the last two and a half years in particular have seen a surge in research published on this topic. This report reviews the work published on climate change, allergens and allergic diseases since 1 January 2013. The review focusses on literature published in the peer-review journal literature, although a number of other prominent sources are also examined. Research of particular significance over the past two and a half years or so includes experimental studies that have quantified changes in allergenicity of pollen under combinations of elevated carbon dioxide and drought stress (for ragweed) and ozone (for Timothy grass). Other extensions of the research on this topic include a number of studies that are considering the impacts of climate change on allergic diseases with increasing sophistication and power. The review also considers recent research related to climate change adaptation in the context of impacts on allergens and allergic diseases. In conclusion, the latest research overall reaffirms this impact as one of the most important impacts of climate change on human health.

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Meteorological and environmental factors that impact pollen counts, allergenicity, and thresholds: A scoping review

Brake

Yaman

Camargo

et al. 2023

allergy asthma proc

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Background: Pollen is a key source of aeroallergens responsible for allergic rhinitis, conjunctivitis, and asthma. Objective: The goal of this scoping review was to summarize current available literature on the factors that affect pollen counts, allergenicity, and thresholds that induce symptoms in individuals who were sensitized. Methods: Several databases showed no published articles with a similar scope as of January 2022. A search of these data bases yielded 373 articles for assessment. These were then reviewed for relevance, and articles were selected to demonstrate the breadth of available data on pollen counts, allergenicity, and thresholds that induce symptoms in individuals who were sensitized. Additional articles were identified through examination of bibliographies of search-identified articles. Results: Several environmental factors have shown a correlation with pollen counts and allergen load, including the distance from the source, wind characteristics, pollen size, terrain, urban environments, air composition (particulate matter, CO2 levels, ozone, NO2), and weather conditions (humidity, thunderstorms, precipitation). Pollen thresholds at which symptoms were induced varied by study, pollen type, symptom, disease, and location. In addition, there was heterogeneity in study designs, threshold definition, and outcome measures. Conclusion: This scoping review demonstrates the plethora of variables that influence the relationship between pollen and the symptoms of allergic diseases. Analysis of the available data sheds light on the complex interaction between environmental and biologic factors that affect pollen's role in allergic diseases and provides guidance on multiple areas for further investigation.

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Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients

Cited by 3 publications

References 20 publications

Ragweed pollen concentration predicts seasonal rhino-conjunctivitis and asthma severity in patients allergic to ragweed

Ragweed pollen concentration predicts seasonal rhino-conjunctivitis and asthma severity in patients allergic to ragweed

Environmental Allergens: from Asthma to Hay Fever and Beyond

Meteorological and environmental factors that impact pollen counts, allergenicity, and thresholds: A scoping review

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