Clerodanes from Polyalthia viridis

Hypotensive activity and toxicology of constituents from root bark ofPolyalthia longifolia var.pendula

“…Purification of fractions 22-23 led to a mixture of bisclerodane imide (6) and its 4(18) olefinic isomer (7) (R f 0.3, CHCl 3 :MeOH, 9.8: 0.2, 25.7 mg). The structures of all these compounds were elucidated partly by detailed spectroscopy and partly by comparison of data with literature values (Kijjoa et al, 1993;Guinaudeau et al, 1983;Hasan et al, 1994).…”

A Novel Clerodane Diterpene from <i>Vitex cofassus</i>

“…pentandra, 20) Polyalthia longifolia, [21][22][23] Solidago altissima, 24,25) and Clausena dunniana. 26) It should be noted that this is the first isolation of clerodane with rearranged ring-A from Vitex species.…”

Constituents ofPolyalthia jucunda. and Their Cytotoxic Effect on Human Cancer Cell Lines

“…The plants of this genus have been found to afford a variety of secondary metabolites, including aporphine (Hamonnière et al, 1977;Jossang et al, 1984;Yang-Chang et al, 1990;Connolly et al, 1996;Kanokmedhakul et al, 2003), azaanthracene (Tuchinda et al, 2000), azafluorene (Yang-Chang et al, 1990), indolosesquiterpene (Hamonnière et al, 1977;Hocquemiller et al, 1981;Okorie, 1981) and protoberberine (Gonzalez et al, 1997, Chung-Yi et al, 2000Faizi et al, 2003) alkaloids; benzopyran derivatives (Zafra-Polo et al, 1996); clerodane (Kijjoa et al,1989(Kijjoa et al, , 1990(Kijjoa et al, , 1993Ma et al, 1994;Hao et al, 1995;Hara et al, 1995), halimane (Hara et al, 1995;Chung-Yi et al, 2000), and labdane diterpenes (Richomme et al, 1991); diynoic acids (Kanokmedhakul et al, 1998;Tuchinda et al, 2001); N-cinnamoyltyramine (Tuchinda et al, 2001) and lanostane-type triterpenes (Li et al, 1993;Lue et al, 1998), and some of these compounds have been found to exhibit interesting biological activity. Whereas some of the aporphine alkaloids and clerodane diterpenes exhibited a cytotoxic effect on human cancer cell lines (Yang-Chang et al, 1990;Ma et al, 1994), the labdane diterpene was found to possess leishmanicidal activity (Richomme et al, 1991).…”