Cleft Lip and Palate: Demographic Patterns and the Associated Communication Disorders

Alfwaress, Firas; Khwaileh, Fadwa A.; Rawashdeh, Ma’amon A.; Alomari, Mahmoud A.; Nazzal, Mohammad

doi:10.1097/scs.0000000000003984

Cited by 23 publications

(25 citation statements)

References 25 publications

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“…Hypoacusis in our study population was the third most frequent clinical feature associated with CL/P, with 1.88% of patients. However, this prevalence is strikingly lower compared to previous reports of 19% to 25% (Alfwaress et al, 2017), and this finding could be a consequence of a less-than-optimal diagnostic rate of this disease, which would encourage the implementation of better assessment protocols to examine patients with CL/P.…”

Section: Discussioncontrasting

confidence: 59%

Clinical and Descriptive Study of Orofacial Clefts in Colombia: 2069 Patients From Operation Smile Foundation

Espinosa

Martínez

Molina

et al. 2021

The Cleft Palate-Craniofacial Journal

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Objective: To describe the population of patients with cleft lip and/or palate (CL/P) in terms of cleft phenotypes, gender, age, ethnic group, family history, clinical presentation (syndromic vs nonsyndromic), some environmental and behavioral factors, and some clinical features. Design: Descriptive retrospective study. Setting: Patients attending the genetics counseling practice in Operation Smile Foundation, Bogotá, Colombia, for over 8 years. Participants: No screening was conducted. All patients requiring clinical genetics assessment in Operation Smile Foundation were included in the study. Results: Left cleft lip and palate (CLP) and nonsyndromic forms were the most frequent types of malformations in this population. Psychomotor retardation and heart disease were the most frequent comorbidities in these patients. A low proportion of mothers exposed to passive smoking during pregnancy was observed and low birth weight accounted for an important number of cases. Aarskog, velocardiofacial, and orofaciodigital syndromes were the most frequent syndromic forms of CLP in this population. Conclusions: In this study, the most frequent type of CL/P was the nonsyndromic complete left CLP. Aarskog, velocardiofacial, and orofaciodigital syndromes were the most frequent syndromic forms of CL/P in this population.

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Section: Discussioncontrasting

confidence: 59%

Clinical and Descriptive Study of Orofacial Clefts in Colombia: 2069 Patients From Operation Smile Foundation

Espinosa

Martínez

Molina

et al. 2021

The Cleft Palate-Craniofacial Journal

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“…The available literature of studies in smaller population cohorts suggests a possible relationship between various measures of socioeconomic status, including education, income, and insurance status, and the incidence of orofacial clefts. [18][19][20][21][22][23] Notably, the association between socioeconomic Fig. 2.…”

Section: Proxy Indicators Of Socioeconomic Status and Cleft Riskmentioning

confidence: 99%

Poverty and Risk of Cleft Lip and Palate: An Analysis of United States Birth Data

Warden

Zimmerman

et al. 2021

Plastic &Amp; Reconstructive Surgery

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rofacial clefts-cleft lip with or without cleft palate and cleft palate only-are among the most common congenital anomalies in the United States and the world. 1,2 Children born with orofacial clefts may experience significant long-term health sequelae, including dental and speech pathologies and stigmatizing appearance differences, even after reconstructive surgery. 3,4 Ample research has explored the multifactorial etiology of orofacial clefts, including disparities in incidence across populations. [5][6][7] Genome-wide association studies have identified multiple populationspecific genetic loci that may predispose individuals to nonsyndromic orofacial clefts. [8][9][10][11][12] The risks of cleft lip with or without cleft palate and cleft palate only also vary across different racial/ethnic groups, with lowest frequencies in African-derived populations and highest in Asians, in general. 6 Maternal factors (such as exposure to tobacco smoke, alcohol, and anticonvulsants) and nutritional deficiencies

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“…Some sociodemographic factors, such as social exclusion, low economic and educational level, and geographical marginalization have been related to increased incidence of CLP in Mexico [30]. Alfwaress et al reported a similar situation in Jordan: CLP children were born in families with low income and low educational levels [31].…”

Section: Environmental Risk Factors and Some Sociodemographic Charmentioning

confidence: 99%

Spatial Clusters of Children with Cleft Lip and Palate and Their Association with Polluted Zones in the Monterrey Metropolitan Area

Gasca-Sanchez

Santos-Guzmán

Elizondo-Dueñaz³

et al. 2019

IJERPH

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This study examines the spatial structure of children with cleft lip and palate (CLP) and its association with polluted areas in the Monterrey Metropolitan Area (MMA). The Nearest Neighbor Index (NNI) and the Spatial Statistical Scan (SaTScan) determined that the CLP cases are agglomerated in spatial clusters distributed in different areas of the city, some of them grouping up to 12 cases of CLP in a radius of 1.2 km. The application of the interpolation by empirical Bayesian kriging (EBK) and the inverse distance weighted (IDW) method showed that 95% of the cases have a spatial interaction with values of particulate matter (PM10) of more than 50 points. The study also shows that 83% of the cases interacted with around 2000 annual tons of greenhouse gases. This study may contribute to other investigations applying techniques for the identification of environmental and genetic factors possibly associated with congenital malformations and for determining the influence of contaminating substances in the incidence of these diseases, particularly CLP.

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Cleft Lip and Palate: Demographic Patterns and the Associated Communication Disorders

Cited by 23 publications

References 25 publications

Clinical and Descriptive Study of Orofacial Clefts in Colombia: 2069 Patients From Operation Smile Foundation

Clinical and Descriptive Study of Orofacial Clefts in Colombia: 2069 Patients From Operation Smile Foundation

Poverty and Risk of Cleft Lip and Palate: An Analysis of United States Birth Data

Spatial Clusters of Children with Cleft Lip and Palate and Their Association with Polluted Zones in the Monterrey Metropolitan Area

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