Clear Cell "Sugar" Tumor of the Lung: A Well-Enhanced Mass with an Early Washout Pattern on Dynamic Contrast-Enhanced Computed Tomography

Kim, Woong Ji; Kim, So Ri; Choe, Yeong Hun; Lee, Ka Young; Park, Seoung Ju; Lee, Heung Bum; Chung, Myoung Ja; Jin, Gong Yong; Lee, Yong Chul

doi:10.3346/jkms.2008.23.6.1121

Cited by 30 publications

(41 citation statements)

References 18 publications

(28 reference statements)

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“…They also seem to mostly affect the elderly. 5 However, there has been a report of an 8-year-old with the tumor. 6 Unfortunately, not enough cases have been reported to establish specific risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…3 Usually, sugar tumors are discovered inadvertently via radiologic films as solitary, round, pulmonary nodules 4 with no lobar preference. 5 Sugar tumors of the lung almost exclusively reside in the parenchyma, yet actual cellular origin remains unknown. 2 The neoplasm is made up of uniform, round, clear cells with welldefined borders.…”

Section: Discussionmentioning

confidence: 99%

“…These metastases also show abundant glycogen, like sugar tumors, but will show reactivity to cytokeratin as well as epithelial membrane antigen. 5 Another leading differential is a clear cell pulmonary carcinoma. 7,8 This type will have abundant mitosis, necrosis, and reactivity to cytokeratin.…”

Section: Discussionmentioning

confidence: 99%

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Clear Cell “Sugar” Tumor of the Lung: Benign or Malignant?

Olivencia‐Yurvati

Rodriguez

2015

International Surgery

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Clear cell ''sugar'' tumors of the lung are rare pulmonary tumors. This case study illustrates a patient who was found to have a persistent nodule in the left-upper lobe of the lung. Positron emission tomographic scanning showed mild-moderate 18-fluorodeoxyglucose uptake. Based on these findings, a video-assisted resection of the tumor was undertaken. The mass was identified histologically, as a clear cell ''sugar'' tumor of the lung. This case report discusses the benign versus malignant nature of this rare tumor.Key words: Clear cell sugar tumor -Rare tumor -Lung tumor -Incidentaloma L ung cancer is one of the leading causes of cancer death in industrialized countries. Early discovery is an important factor for survivability. With only a limited number of cases reported, 1 clear cell (sugar) lung tumors are extraordinarily rare. These particular lung tumors have been described as benign neoplasms that have a considerable amount of intracellular glycogen among other diagnostic features. The characteristic presence of such a high amount of glycogen has led to these tumors as often being referred to as simply, sugar tumors of the lung. The purpose of this report is to add to other reported cases of this rare pulmonary lesion, through a comprehensive literature review. The goals are to inform physicians of this rare entity, and to discuss how these tumors can be confused with malignant tumors. CaseA 39-year-old, well-developed female presented with evidence of a persistent nodule located in the left-upper lobe of the lung. A whole body positron emission tomographic/computed tomography (PET/CT) showed the nodule measuring approximately 1.1 cm 3 1.0 cm in size along with persistent ground glass type infiltrate. The 18-fluorodeoxyglucose uptake was positive. The nodule was also shown to be changing with serial films, with an increase in size. The structural exam was normal except for paravertebral tissue fullness around T2 to T5. It was recommended that she undergo videoassisted thoracoscopic resection of the lesion. A wedge resection was carried out and the lesion was successfully removed alongside normal surrounding parenchyma. Frozen sections showed evidence of inflammatory cells surrounding the nodule, but no evidence of malignancy. During the operation, both the lesion and the lung parenchyma were opened and aerobic, anaerobic, and acid-fast cultures were obtained. The rest of the lung appeared healthy with no pleural effusions or any other abnormalities. The operation was well-tolerated and the patient recovered completely and continued to do well on postsurgical cardiothoracic surgical clinic visits. Final pathology was consistent with benign sugar tumor (Fig.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clear Cell “Sugar” Tumor of the Lung: Benign or Malignant?

Olivencia‐Yurvati

Rodriguez

2015

International Surgery

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“…Because of the rich vascular stroma, most CCTLs show homogenous intense enhancement on CT scans. Kim et al (8), reported an early wash-in and washout pattern of CCTL on dynamic CT. CCTLs usually show no 18 F-2-deoxy-D-glucose (FDG) uptake, but a 2.8-cm benign CCTL that showed extensive FDG uptake has been reported (9).…”

Section: Discussionmentioning

confidence: 99%

Growth pattern change of a benign clear cell ‘sugar’ tumor of the lung: Serial imaging surveillance over seven years

et al. 2018

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Clear cell tumor of the lung is a rare benign mesenchymal tumor and only sporadic cases have been previously reported. The present study reports the case of a 58-year-old man who presented with an incidentally detected solitary pulmonary nodule. Based on comparisons with serial previous chest and spine radiographs, a growth pattern change in the nodule (initial gradual growth over 4.5 years, then recent no growth over 2.5 years) was identified. The nodule was diagnosed as a benign clear cell tumor of the lung (CCTL) following surgical resection. Few studies have previously reported interval growth of CCTLs and the growth pattern of CCTL is not yet well known. To the best of our knowledge, this is the first reported case in which the growth pattern change of CCTL was identified via serial imaging over 7 years of follow-up.

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“…The sugar tumor may occur in any lobe and is mainly located under the pleura, with no communication with the bronchi [3]. It occurs in all age groups, but is most often seen in the elderly, and affects both sexes equally [4].…”

Section: Introductionmentioning

confidence: 99%