Growth pattern change of a benign clear cell ‘sugar’ tumor of the lung: Serial imaging surveillance over seven years

Abstract

Clear cell tumor of the lung is a rare benign mesenchymal tumor and only sporadic cases have been previously reported. The present study reports the case of a 58-year-old man who presented with an incidentally detected solitary pulmonary nodule. Based on comparisons with serial previous chest and spine radiographs, a growth pattern change in the nodule (initial gradual growth over 4.5 years, then recent no growth over 2.5 years) was identified. The nodule was diagnosed as a benign clear cell tumor of the lung (CCTL) following surgical resection. Few studies have previously reported interval growth of CCTLs and the growth pattern of CCTL is not yet well known. To the best of our knowledge, this is the first reported case in which the growth pattern change of CCTL was identified via serial imaging over 7 years of follow-up.

Perivascular epithelioid cell tumor of the lung: A case report and literature review

“…We searched PubMed, Embase, the Cochrane Library, the China National Knowledge Infrastructure, the Wanfang Data, and the China Science and Technology Journal database with the search terms “perivascular epithelioid cell tumor”, “PEComa”, “clear cell sugar tumor” and “CCST” from inception to January 22, 2022. We retrieved 29 case reports 4–32 of primary lung PEComa, which are summarized in Table 2. They included 12 female patients and 17 male patients, ranging from 28 to 79 years old (mean age 54 years).…”

Early clear cell “sugar” lung cancer management: A case report and a brief literature review

“…As clear cell lung carcinoma can also be a manifestation of metastatic renal cell carcinoma or other subtype of clear cell carcinoma originating from different types of lung cells, making a differential diagnosis is a fundamental step before commencing treatment. An important feature that differentiates CCTL from other types of lung cancer, such as metastatic clear cell tumors or other clear cell tumor variants, is the presence of immunoreactivity for CD10, CK, and EMA . CK positivity is a characteristic of both primary and secondary clear cell adenocarcinomas of the lung .…”

“…An important feature that differentiates CCTL from other types of lung cancer, such as metastatic clear cell tumors or other clear cell tumor variants, is the presence of immunoreactivity for CD10, CK, and EMA. 20,21 CK positivity is a characteristic of both primary and secondary clear cell adenocarcinomas of the lung. 13 In our case, the diagnosis was based on the typical histological picture of the tumor: positivity for CD10, vimentin, pan-cytokeratin MNF116, and CK7, and negative for TTF-1.…”

“…In light of the few cases described in the literature, cytomorphologic aspects, such as growth pattern changes, and clinical features, such as the detection time and observation period, will help clinicians in the diagnostic and therapeutic process, permitting the conservative management of these patients . Therefore, a better understanding of the pathological, immunophenotype features and natural history of this rare tumor is extremely important to prepare detailed and practical clinical guidelines.…”

PEComa of the Lung: a Rare Entity

“…CCTL usually presents as asymptomatic peripheral solitary nodule with no evidence of cavitation or calcification [13]. The typical characteristics of the CCTL on contrastenhanced CT scans are the intense heterogeneous enhancement in the arterial phase and washout in the delay phase [14].…”