Clear cell papillary renal cell carcinoma: an update after 15 years

Williamson, Sean R.

doi:10.1016/j.pathol.2020.10.002

Cited by 39 publications

(32 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although VGLL4 is rarely mutated in human cancer, it is located at the short arm (3p) of chromosome 3, which is lost in many types of cancer ( Williamson, 2002 ; Cancer Genome Atlas Research Network, 2013 ; Jonasch et al, 2020 ; Nidorf et al, 2020 ; Shaikh et al, 2020 ). The Cancer Genome Atlas (TCGA) Research Network found that around 90% of clear cell renal carcinoma patients exhibit loss of one or both copies of chromosome 3p.…”

Section: Vgll4mentioning

confidence: 99%

Mutations and Copy Number Abnormalities of Hippo Pathway Components in Human Cancers

Jiang

2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

The Hippo pathway is highly conserved from Drosophila to mammals. As a key regulator of cell proliferation, the Hippo pathway controls tissue homeostasis and has a major impact on tumorigenesis. The originally defined core components of the Hippo pathway in mammals include STK3/4, LATS1/2, YAP1/TAZ, TEAD, VGLL4, and NF2. However, for most of these genes, mutations and copy number variations are relatively uncommon in human cancer. Several other recently identified upstream and downstream regulators of Hippo signaling, including FAT1, SHANK2, Gq/11, and SWI/SNF complex, are more commonly dysregulated in human cancer at the genomic level. This review will discuss major genomic events in human cancer that enable cancer cells to escape the tumor-suppressive effects of Hippo signaling.

show abstract

Section: Vgll4mentioning

confidence: 99%

Mutations and Copy Number Abnormalities of Hippo Pathway Components in Human Cancers

Jiang

2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…Renal cell carcinoma (RCC) is the most prevalent and malignant kidney cancer in adults, accounting for 3.7% of all malignancies in adults globally [1]. Worldwide, RCC is the major cause of cancer-related morbidity and death [2].…”

Section: Introductionmentioning

confidence: 99%

A Novel Pyroptosis-Related lncRNAs Signature for Predicting the Prognosis of Kidney Renal Clear Cell Carcinoma and Its Associations with Immunity

Tang

Zhang

Feng

et al. 2021

Journal of Oncology

View full text Add to dashboard Cite

The most common kind of kidney cancer with poor prognosis is clear cell renal cell carcinoma (ccRCC). Pyroptosis is shown to be an inflammatory type of programmed cell death in recent years. In this research, we utilized pyroptosis-related differentially expressed lncRNAs in ccRCC to develop a predictive multi-lncRNA signature. We uncovered 14 lncRNAs with different expression patterns that were linked to ccRCC prognosis. Kaplan–Meier analysis identified a signature of high-risk lncRNAs related to poor prognosis for ccRCC. Furthermore, the AUC of the lncRNA signature was 0.771, indicating that they can be used to predict ccRCC prognosis. In predicting ccRCC prognosis, our risk analysis approach outperformed standard clinicopathological characteristics. In the low-risk group, GSEA indicated tumor-related pathways. T-cell functions such as T-cell coinhibition and T-cell costimulation were found to be expressed differently in two groups. Immune checkpoints including PD-1, LAG3, CTLA4, and BTLA were also differently expressed between the two groups. In patients with ccRCC, we created a 14-lncRNA-based predictor as a robust prognostic and predictive tool for OS.

show abstract

“…In renal cell carcinomas, GATA3 is frequently expressed in chromophobe renal cell carcinomas, renal oncocytoma, and clear cell papillary renal cell carcinoma [51,52]. These types of tumors are often derived from the collecting ducts that is the physiological GATA3 expression sites in nephrons, implying GATA3 partake in the cell-intrinsic carcinogenic mechanism [13,53,54].…”

Section: Gata3 and Urogenital Cancersmentioning

confidence: 99%

Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital Systems

Moriguchi

2021

Biomedicines

View full text Add to dashboard Cite

The GATA family of transcription factors consists of six proteins (GATA1-6) that control a variety of physiological and pathological processes. In particular, GATA2 and GATA3 are coexpressed in a number of tissues, including in the urogenital and sympathoadrenal systems, in which both factors participate in the developmental process and tissue maintenance. Furthermore, accumulating studies have demonstrated that GATA2 and GATA3 are involved in distinct types of inherited diseases as well as carcinogenesis in diverse tissues. This review summarizes our current knowledge of how GATA2 and GATA3 participate in the transcriptional regulatory circuitry during the development of the sympathoadrenal and urogenital systems, and how their dysregulation results in the carcinogenesis of neuroblastoma, renal urothelial, and gynecologic cancers.

show abstract

Clear cell papillary renal cell carcinoma: an update after 15 years

Cited by 39 publications

References 83 publications

Mutations and Copy Number Abnormalities of Hippo Pathway Components in Human Cancers

Mutations and Copy Number Abnormalities of Hippo Pathway Components in Human Cancers

A Novel Pyroptosis-Related lncRNAs Signature for Predicting the Prognosis of Kidney Renal Clear Cell Carcinoma and Its Associations with Immunity

Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital Systems

Contact Info

Product

Resources

About