A Novel Pyroptosis-Related lncRNAs Signature for Predicting the Prognosis of Kidney Renal Clear Cell Carcinoma and Its Associations with Immunity

Abstract

The most common kind of kidney cancer with poor prognosis is clear cell renal cell carcinoma (ccRCC). Pyroptosis is shown to be an inflammatory type of programmed cell death in recent years. In this research, we utilized pyroptosis-related differentially expressed lncRNAs in ccRCC to develop a predictive multi-lncRNA signature. We uncovered 14 lncRNAs with different expression patterns that were linked to ccRCC prognosis. Kaplan–Meier analysis identified a signature of high-risk lncRNAs related to poor prognosis for ccRCC. Furthermore, the AUC of the lncRNA signature was 0.771, indicating that they can be used to predict ccRCC prognosis. In predicting ccRCC prognosis, our risk analysis approach outperformed standard clinicopathological characteristics. In the low-risk group, GSEA indicated tumor-related pathways. T-cell functions such as T-cell coinhibition and T-cell costimulation were found to be expressed differently in two groups. Immune checkpoints including PD-1, LAG3, CTLA4, and BTLA were also differently expressed between the two groups. In patients with ccRCC, we created a 14-lncRNA-based predictor as a robust prognostic and predictive tool for OS.

Comprehensive Analysis of the Correlation Between Pyroptosis-Related LncRNAs and Tumor Microenvironment, Prognosis, and Immune Infiltration in Hepatocellular Carcinoma

“…Although the association of PRLs with breast cancer and clear cell carcinoma has been investigated ( Gao and Li, 2021 ; Tang et al, 2021 ), the role of these lncRNAs in HCC remains to be elucidated. Our study revealed the association of seven PRLs with HCC immune infiltration, immune checkpoint gene expression, and prognosis, and this signature was able to discriminate between different tumor stages and pathological grades.…”

A Prognostic Pyroptosis-Related lncRNAs Risk Model Correlates With the Immune Microenvironment in Colon Adenocarcinoma

“…However, the value of the Pearson correlation coefficient was small, and there were no external datasets to validate their signature. Tang et al built a pyroptosis-related lncRNAs signature for predicting the prognosis of clear cell renal cell carcinoma (ccRCC) ( Tang et al, 2021 ). They performed a large enrichment analysis to reveal the roles of pyroptosis-related lncRNAs in ccRCC from their biological functions.…”

No Time to Die: How Kidney Cancer Evades Cell Death

“…Thus, pyroptosis plays a dual role during tumor progression [ 106 ]. Current research reveals that pyroptosis is also involved in the occurrence and development of kidney diseases and kidney cancer, emphasizing their relationship, and questioning the potential therapeutic targets relating to this cell death mechanism [ 7 , 107 , 108 , 109 , 110 , 111 ]. Kidney cancer is characterized by uncontrolled cell proliferation, the absence of cell death, and different sensitivity to conventional radio- and chemotherapies [ 112 ].…”