Clear cell carcinoma of the palate

Grenevicki, Lance F.; Barker, Bruce F.; Fiorella, Russell M.; Mosby, Edward L.

doi:10.1054/ijom.2001.0116

Cited by 34 publications

(28 citation statements)

References 7 publications

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“…Grenevicki et al [10] 53/F Palate n/a 5 n/a n/a n/a n/a n/a n/a ? Manoharan et al [11] 40/F L floor of mouth Solid, gray-white…”

Section: Discussionmentioning

confidence: 99%

“…Metastases and/or local recurrences were identified in approximately one-third of cases [1,2,5,7,8,10,15,22]. Nine cases reported metastases (16.4%), five identified at the time of initial diagnosis [1,5,7,8,10,15], one at 4 months [15], one at 3 years [8], one at 5 years [5], and one at 7 years [8]. The majority of metastases traveled to local lymph nodes and three cases showed distant metastases to the lung, with two of the three lung metastases identified at the time of diagnosis [7,10,15].…”

Section: Discussionmentioning

confidence: 99%

“…Nine cases reported metastases (16.4%), five identified at the time of initial diagnosis [1,5,7,8,10,15], one at 4 months [15], one at 3 years [8], one at 5 years [5], and one at 7 years [8]. The majority of metastases traveled to local lymph nodes and three cases showed distant metastases to the lung, with two of the three lung metastases identified at the time of diagnosis [7,10,15]. In the nine cases with reported recurrences (16.4%), the time span between initial diagnosis and local recurrence ranged from 11 months [5] up to 6 years [8].…”

Section: Discussionmentioning

confidence: 99%

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Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of Literature

O’Sullivan‐Mejia

Massey

Faquin

et al. 2009

Head and Neck Pathol

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Hyalinizing clear cell carcinoma (HCCC) is an extremely rare neoplasm with a female predominance, composed of nests of monomorphic clear cells within a hyaline stroma. This tumor often follows an indolent course and treatment includes wide surgical excision with or without adjuvant radiotherapy. We report eight cases of HCCC identified at two academic institutions in six women and two men, ranging in age from 25 to 86 years. Histologically, all cases demonstrated cords, trabeculae, and nests of monomorphic clear cells as well as cells with eosinophilic granular cytoplasm. Mild cellular atypia was occasionally seen and mitoses were very rare. Seven cases demonstrated a hyalinized stroma, and one case, a myxoid stroma. Immunohistochemically, the tumor cells were positive for epithelial markers and negative for desmin and actin. Seven cases were negative for S-100. Cells were also positive for periodic acidSchiff and negative for mucin. The important clinicopathologic features and the differential diagnoses of HCCC, as well as a review of the literature are discussed.

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“…Grenevicki et al [10] 53/F Palate n/a 5 n/a n/a n/a n/a n/a n/a ? Manoharan et al [11] 40/F L floor of mouth Solid, gray-white…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of Literature

O’Sullivan‐Mejia

Massey

Faquin

et al. 2009

Head and Neck Pathol

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“…It is a rare entity accounting for less than 1% of all salivary gland tumours 6 . They arise from the minor salivary glands within the oral cavity and are commonly located in the palate, lips and buccal mucosa 5,7 . Base of tongue 1 , hypopharynx 4 , larynx 4 , nasal cavity 8 and jaw bones 2 are the other rare documented sites of tumour occurrence.…”

Section: Discussionmentioning

confidence: 99%

Hyalinizing clear cell carcinoma of the base of tongue

Pujary

Rangarajan

Nayak

et al. 2008

International Journal of Oral and Maxillofacial Surgery

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“…[1] A few cases of the tumor metastasizing to the regional lymph nodes and two cases with metastasis to the lungs have also been reported in the literature. [8,9] Although increased mitosis was found in these cases, it is not a reliable feature in predicting tumor behavior as this feature was also seen in tumors with no metastasis. [8] Jin et al, [10] has described a case of recurrence of clear cell carcinoma of salivary gland on tongue confirmed by the presence of EWSR1 gene rearrangement, and found that that the presence of "dedifferentiated" high grade HCCC may reoccur as low grade tumor even after undergoing extensive radiotherapy.…”

Section: Discussionmentioning

confidence: 94%

Post-radiotherapy locoregional recurrence of hyalinizing clear cell carcinoma of palate

et al. 2013

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Clear cell carcinoma of the salivary glands is a rare tumor that represents less than 1% of all salivary tumors and is a new disease that is only recognized in recent years. It is rare and the standard treatment is still under investigation. This tumor often follows an indolent course and treatment includes wide surgical excision with or without adjuvant radiotherapy. Recurrence of the hyalinizing clear cell carcinoma (HCCC) after complete surgical resection is uncommonly documented. We hereby report a case of post-radiotherapy locoregional recurrence of HCCC of the palate and recommend further clinicopathological study and long-term follow-up to document the biological behavior of this entity along with highlighting the role of special stains and immunohistochemistry in its diagnosis.

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Clear cell carcinoma of the palate

Cited by 34 publications

References 7 publications

Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of Literature

Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of Literature

Hyalinizing clear cell carcinoma of the base of tongue

Post-radiotherapy locoregional recurrence of hyalinizing clear cell carcinoma of palate

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