Post-radiotherapy locoregional recurrence of hyalinizing clear cell carcinoma of palate

Abstract

Clear cell carcinoma of the salivary glands is a rare tumor that represents less than 1% of all salivary tumors and is a new disease that is only recognized in recent years. It is rare and the standard treatment is still under investigation. This tumor often follows an indolent course and treatment includes wide surgical excision with or without adjuvant radiotherapy. Recurrence of the hyalinizing clear cell carcinoma (HCCC) after complete surgical resection is uncommonly documented. We hereby report a case of post-radiotherapy locoregional recurrence of HCCC of the palate and recommend further clinicopathological study and long-term follow-up to document the biological behavior of this entity along with highlighting the role of special stains and immunohistochemistry in its diagnosis.

Hyalinizing clear cell carcinoma of the head and neck: Case series and update

“…Our review of the literature revealed 130 cases of HCCC among 48 articles . We did exclude a number of articles that have been reported by others to represent HCCC but, in our view, did not provide sufficient histologic description to confirm the diagnosis .…”

Reappraising hyalinizing clear cell carcinoma: A population‐based study with molecular confirmation

“…Neck dissection, where specified, was usually unilateral, and limited to supraomohyoid levels I to III. Adjuvant or neoadjuvant therapy was performed in 26 cases, including 8 patients who had also undergone lymph node dissection . Radiation was the preferred adjuvant modality in 24 cases, with combined chemotherapy/radiotherapy being administered in 2 cases.…”

Nasopharyngeal hyalinizing clear cell carcinoma with EWSR1 rearrangements diagnosed by fluorescence in situ hybridization

“…Post-operative radiotherapy is recommended when a total surgical removal of the primary tumor is not attainable [13]. However, Gon et al [2] reported a case of locoregional recurrence after 6 years, despite all surgical margins being free of neoplasms and administration of three cycles of adjuvant radiotherapy, suggesting that the therapeutic value of radiotherapy for HCCC may be limited.…”

“…Hyalinizing clear cell carcinoma (HCCC) was first described by Milchgrub et al as a rare carcinoma of the minor salivary glands [1], representing less than 1% of all salivary tumors [2]. The tumor is characterized by low-grade morphology with only occasional metastatic spread that can achieve good overall treatment outcome [3].…”

“…HCCC exclusively comprises epithelial cells with optically clear cytoplasm that are positive for cytokeratin and negative for S-100 protein and smooth muscle actin [2].…”