Hyalinizing clear cell carcinoma of the base of tongue

Pujary, Kailesh; Rangarajan, Sanjeet; Nayak, Dipak Ranjan; Balakrishnan, R.; Ramakrishnan, Venkat M.

doi:10.1016/j.ijom.2007.06.014

Cited by 25 publications

(22 citation statements)

References 10 publications

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“…The recommended treatment for HCCC is wide surgical resection as benefits from adjuvant treatment have not been confirmed and the effect of chemotherapy remains unknown. Post-operative radiotherapy is recommended when a total surgical removal of the primary tumor is not attainable [13]. However, Gon et al [2] reported a case of locoregional recurrence after 6 years, despite all surgical margins being free of neoplasms and administration of three cycles of adjuvant radiotherapy, suggesting that the therapeutic value of radiotherapy for HCCC may be limited.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal hyalinizing clear cell carcinoma with EWSR1 rearrangements diagnosed by fluorescence in situ hybridization

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Nasopharyngeal hyalinizing clear cell carcinoma with EWSR1 rearrangements diagnosed by fluorescence in situ hybridization

et al. 2015

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“…HCCC should be considered in the differential diagnosis of tumors with the histology marked by monomorphic clear cells arranged in cords, trabeculae, or clusters surrounded by a hyalinized stroma. [18] n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a Pujari et al [19] 57/M L base of tongue Grey-white, solid 3 ? n/a n/a n/a n/a n/a ?…”

Section: Discussionmentioning

confidence: 99%

Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of Literature

O’Sullivan‐Mejia

Massey

Faquin

et al. 2009

Head and Neck Pathol

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Hyalinizing clear cell carcinoma (HCCC) is an extremely rare neoplasm with a female predominance, composed of nests of monomorphic clear cells within a hyaline stroma. This tumor often follows an indolent course and treatment includes wide surgical excision with or without adjuvant radiotherapy. We report eight cases of HCCC identified at two academic institutions in six women and two men, ranging in age from 25 to 86 years. Histologically, all cases demonstrated cords, trabeculae, and nests of monomorphic clear cells as well as cells with eosinophilic granular cytoplasm. Mild cellular atypia was occasionally seen and mitoses were very rare. Seven cases demonstrated a hyalinized stroma, and one case, a myxoid stroma. Immunohistochemically, the tumor cells were positive for epithelial markers and negative for desmin and actin. Seven cases were negative for S-100. Cells were also positive for periodic acidSchiff and negative for mucin. The important clinicopathologic features and the differential diagnoses of HCCC, as well as a review of the literature are discussed.

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“…Neoplastic cells in renal cell carcinoma coexpress cytokeratin and vimentin, whereas neoplastic cells in HCCC are negative for vimentin. [2] As clear cell carcinoma is rare, few treatment protocols have ever been described. Being a tumor of low malignant potential, wide surgical resection is the treatment of choice with, or without, pre-/post-operative radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…[1] It is composed exclusively of epithelial cells with optically clear cytoplasm. [2] These cells are positive for cytokeratin and negative for S-100 protein and smooth muscle actin. This immunohistochemical staining differentiates it from other tumors of the oral cavity having a predominantly clear cell component and also indicates that HCCC is composed only of epithelial cells.…”

Section: Introductionmentioning

confidence: 97%

Post-radiotherapy locoregional recurrence of hyalinizing clear cell carcinoma of palate

et al. 2013

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Clear cell carcinoma of the salivary glands is a rare tumor that represents less than 1% of all salivary tumors and is a new disease that is only recognized in recent years. It is rare and the standard treatment is still under investigation. This tumor often follows an indolent course and treatment includes wide surgical excision with or without adjuvant radiotherapy. Recurrence of the hyalinizing clear cell carcinoma (HCCC) after complete surgical resection is uncommonly documented. We hereby report a case of post-radiotherapy locoregional recurrence of HCCC of the palate and recommend further clinicopathological study and long-term follow-up to document the biological behavior of this entity along with highlighting the role of special stains and immunohistochemistry in its diagnosis.

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Hyalinizing clear cell carcinoma of the base of tongue

Cited by 25 publications

References 10 publications

Nasopharyngeal hyalinizing clear cell carcinoma with EWSR1 rearrangements diagnosed by fluorescence in situ hybridization

Nasopharyngeal hyalinizing clear cell carcinoma with EWSR1 rearrangements diagnosed by fluorescence in situ hybridization

Hyalinizing Clear Cell Carcinoma: Report of Eight Cases and a Review of Literature

Post-radiotherapy locoregional recurrence of hyalinizing clear cell carcinoma of palate

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