Clastogenic effects of copper sulphate in chick in vivo test system

Induction of Micronuclei in Eel (Anguilla anguilla L.) by Heavy Metals

“…Induction of micronuclei by copper or zinc injections were not expected, as both metals are essential for metabolic pathways. Although in chicken a signi"cant increase of micronuclei induced by copper sulfate was found (Bhunya and Jena, 1996), the low dose employed in this work did not produce signi"cant micronuclei induction in eels. Target species for genotoxicity studies are those widely distributed among ecosystems, easy to maintain in laboratory conditions, and sensitive to genotoxic substances.…”

Regulation of p53 by Metal Ions and by Antioxidants: Dithiocarbamate Down-Regulates p53 DNA-Binding Activity by Increasing the Intracellular Level of Copper

“…In turn, Cu 1ϩ reacts with molecular oxygen to form O 2 Ϫ , which dismutates to H 2 O 2 and O 2 , ultimately producing hydroxyl radicals and other reactive oxygen species. These active oxygen species can cause oxidative DNA damage and are responsible for the clastogenic potential of copper (2,5,49).…”

The Effects of Copper Sulfate on Liver Histology and Biochemical Parameters of Term Ross Broiler Chicks

“…There is evidence of the genotoxic potential of copper sulfate in chicks in vivo [3], with teratogenicity of metals to chick embryos also seen at high copper sulfate doses [4]. Indeed, in a more recent series of studies on mainly chicken embryo toxicity and teratogenicity of a number of herbicides, insecticides, and fungicides, Varnagy and colleagues modeled these effects to the heavy metal load of the environment, sometimes incorporating copper as their control [5][6][7][8][9].…”