Clastogenic effects of acrylamide in mouse bone marrow cells

Adler, I.‐D.; Ingwersen, Ingrid; Kliesch, U.; Tarras, A. El

doi:10.1016/0165-1218(88)90124-3

Cited by 71 publications

(19 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, the results of other AA studies suggest that the late spermatids and spermatozoa are the most susceptible to damage [13,15,17,[44][45][46] . In previous studies, a significant increase in micronucleus frequency in bone marrow was observed 24 h after treatment with 50-100 mg/kg bw of AA [4,6,7]. In our study the dose of 75 mg/kg bw was not mutagenic in the micronucleus test, nor in the dominant lethal study done earlier [14].…”

Section: Discussioncontrasting

confidence: 63%

“…The results of toxicology, mutagenesis, and carcinogenesis evaluations of AA have been reviewed by the IARC [1]. AA induces chromosomal aberrations and micronuclei in mouse bone marrow [4][5][6][7] and in spermatogonia of male mice [6,8]. Several authors have found positive effects in micronucleus tests in spermatids of rodents [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Induction of micronuclei in bone marrow and sperm head abnormalities after combined exposure of mice to low doses of X-rays and acrylamide

Dobrzyńska¹,

Gajewski²

2000

Teratog. Carcinog. Mutagen.

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Induction of micronuclei in bone marrow and sperm head abnormalities after combined exposure of mice to low doses of X-rays and acrylamide

Dobrzyńska¹,

Gajewski²

2000

Teratog. Carcinog. Mutagen.

View full text Add to dashboard Cite

“…17 h later animals were injected intraperitoneally with colchicine solution (0.06%/kg body weight) and 1 h later the animals were killed by cervical dislocation (Adler et al, 1988). Bone marrow cells were routinely processed by standard procedure.…”

Section: Animals and Chemicalsmentioning

confidence: 99%

Clastogenic effect of ginger rhizome in mice

Mukhopadhyay

Mukherjee

2000

Phytother. Res.

View full text Add to dashboard Cite

“…c) Evidence (10) and nitr ogen mustard (11). "Acrylamide results are updated from the riecent literature (12)(13)(14).…”

Section: Methodsmentioning

confidence: 99%

Hazard identification: efficiency of short-term tests in identifying germ cell mutagens and putative nongenotoxic carcinogens.

Waters

Stack

Jackson

et al. 1993

Environ Health Perspect

View full text Add to dashboard Cite

For more than a decade, mutagenicity tests have had a clearly defined role in the identification of potential human mutagens and an ancillary role in the identification of potential human carcinogens. The efficiency of short-term tests in identifying germ cell mutagens has been examined using a combined data set derived from the U.S. Environmental Protection Agency/International Agency for Research on Cancer Genetic Activity Profile (EPA/IARC GAP) and EPA Gene-Tox databases. Our review of these data indicates adequate sensitivity of batteries of in vitro short-term mutagenicity tests in identifying germ cell mutagens. The analysis also supports the inclusion of an in vivo assay as suggested in proposed regulatory testing guidelines. In the context of carcinogenicity testing, the ability of short-term bioassays to detect genotoxic or mutagenic carcinogens is well established. Such tests are not considered to be as sensitive to nongenotoxic or nonmutagenic carcinogens. However, analyses presented in this report using the EPA/IARC GAP database demonstrate that many putative nongenotoxic carcinogens that have been adequately tested in short-term genetic bioassays induce gene or chromosomal mutation or aneuploidy. Further investigation should reveal whether the mutagenicity of these agents plays an important mechanistic role in their carcinogenicity.

show abstract

Clastogenic effects of acrylamide in mouse bone marrow cells

Cited by 71 publications

References 15 publications

Induction of micronuclei in bone marrow and sperm head abnormalities after combined exposure of mice to low doses of X-rays and acrylamide

Induction of micronuclei in bone marrow and sperm head abnormalities after combined exposure of mice to low doses of X-rays and acrylamide

Clastogenic effect of ginger rhizome in mice

Hazard identification: efficiency of short-term tests in identifying germ cell mutagens and putative nongenotoxic carcinogens.

Contact Info

Product

Resources

About