Clastogenic effect of ginger rhizome in mice

Mukhopadhyay, Madhumita; Mukherjee, Anita

doi:10.1002/1099-1573(200011)14:7<555::aid-ptr659>3.0.co;2-j

Cited by 10 publications

(2 citation statements)

References 16 publications

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“…Arsenic compounds were used in the present study to understand the protective nature of H. sabdariffa. In earlier studies several crude extracts of plants and vegetables were shown to significantly reduce the cytotoxic and carcinogens effects of toxic metals and chemical such as: zinc, lead, sodium arsenite, mitomycin C and cyclophosphamide in bone marrow cells [21][22][23]. The present study elucidates the antigenotoxic potential of HSE in a dose dependent manner which can presumably be attributed to its antioxidant properties.…”

Section: Introductionsupporting

confidence: 53%

Evaluation of the Protective Effect of Hibiscus sabdariffa L. Calyx (Malvaceae) Extract on Arsenic Induced Genotoxicity in Mice and Analysis of its Antioxidant Properties

Poddar¹

2014

Biol Med (Aligarh)

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The present study envisages the antigenotoxic property of Hibiscus sabdariffa L. (Roselle) calyx extracts that is presumably attributed to its antioxidant properties. The dried calyx extracts of Roselle were administered to male albino mice at doses of 50, 100, and 150 mg/kg body weight for 7 days followed by a single dose of interperitoneal (i.p.) injection of sodium arsenite (2.5 mg/kg body weight) and the extent of DNA damage was analysed by widely used Comet assay. The results revealed that the calyx extract of Roselle inhibited the DNA damage induced by sodium arsenite in a dose dependent manner. The presence of phytochemical constituents such as polyphenols and flavonoids were ascribed to the observed changes. The antioxidant efficacy was substantiated by applying Ferric Reducing Antioxidant Power (FRAP) and 2, 2-di(4-tert-octylphenyl)-1-picrylhydrazyl (DPPH) assays. B io lo g y and M e d ic in e

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Section: Introductionsupporting

confidence: 53%

Evaluation of the Protective Effect of Hibiscus sabdariffa L. Calyx (Malvaceae) Extract on Arsenic Induced Genotoxicity in Mice and Analysis of its Antioxidant Properties

Poddar¹

2014

Biol Med (Aligarh)

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“…or ginger oil (0.63-2.50 ml/kg body weight, i.p.) induced chromosomal aberrations in the bone marrow of male Swiss mice [Mukhopadhyay and Murkerjee 2000]. Also, 100-700 lM [6]-gingerol and [6]-shagoal were potent mutagens in strain Hs30 of Escherichia coli [Nakamura and Yamamoto, 1983] as well as in Salmonella typhimurium strains TA100 and TA1535 with exogenous metabolic activation [Nagabhushan et al, 1987].…”

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confidence: 99%

Effects of ginger (Zingiber officinale Roscoe) on DNA damage and development of urothelial tumors in a mouse bladder carcinogenesis model

Bidinotto

Spinardi-Barbisan

Rocha

et al. 2006

Environ and Mol Mutagen

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Extracts of the spice ginger (Zingiber officinale Roscoe) are rich in gingerols and shogaols, which exhibit antioxidant, anti-inflammatory, antifungal, antimycobacterial, and anticarcinogenic proprieties. The present study evaluated the chemoprotective effects of a ginger extract on the DNA damage and the development of bladder cancer induced by N-butyl-N-(4-hydroxibutyl) nitrosamine (BBN)/N-methyl-N-nitrosourea (MNU) in male Swiss mice. Groups G1-G3 were given 0.05% BBN in drinking water for 18 weeks and four i.p. injections of 30 mg/kg body weight MNU at 1, 3, 10, and 18 weeks. Group G4 and G5 received only the BBN or MNU treatments, respectively, and groups G6 and G7 were not treated with BBN or MNU. Additionally, Groups G2, G3, and G6 were fed diets containing 1, 2, and 2% ginger extract, respectively, while Groups G1, G4, G5, and G7 were fed basal diet. Samples of peripheral blood were collected during the experiment for genotoxicity analysis; blood collected 4 hr after each MNU dose was used for the analysis of DNA damage with the Comet assay (assay performed on leukocytes from all groups), while reticulocytes collected 24 hr after the last MNU treatment of Groups G5-G7 were used for the micronucleus assay. At the end of the experiment, the urinary bladder was removed, fixed, and prepared for histopathological, cell proliferation, and apoptosis evaluations. Ginger by itself was not genotoxic, and it did not alter the DNA damage levels induced by the BBN/MNU treatment during the course of the exposure. The incidence and multiplicity of simple and nodular hyperplasia and transitional cell carcinoma (TCC) were increased by the BBN/MNU treatment, but dietary ginger had no significant effect on these responses. However, in Group G2 (BBN/MNU/2% ginger-treated group), there was an increased incidence of Grade 2 TCC. The results suggest that ginger extract does not inhibit the development of BBN-induced mouse bladder tumors.

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Zingiber officinale

Medicinal Plants of the World, Volume 3

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Clastogenic effect of ginger rhizome in mice

Cited by 10 publications

References 16 publications

Evaluation of the Protective Effect of Hibiscus sabdariffa L. Calyx (Malvaceae) Extract on Arsenic Induced Genotoxicity in Mice and Analysis of its Antioxidant Properties

Evaluation of the Protective Effect of Hibiscus sabdariffa L. Calyx (Malvaceae) Extract on Arsenic Induced Genotoxicity in Mice and Analysis of its Antioxidant Properties

Effects of ginger (Zingiber officinale Roscoe) on DNA damage and development of urothelial tumors in a mouse bladder carcinogenesis model

Zingiber officinale

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