Classification of congenital pouch colon based on anatomic morphology

Saxena, Amulya K.; Mathur, Praveen

doi:10.1007/s00384-008-0450-z

Cited by 36 publications

(36 citation statements)

References 9 publications

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“…It was first defined in 1959 [1]. Cases were reported especially from North India [4][5][6]. This anomaly has recently been defined as having 4 types.…”

Section: Discussionmentioning

confidence: 98%

Abdominotransanal approach to pouch colon associated with rectal atresia

Kazez

Özel

Bakal

et al. 2009

Journal of Pediatric Surgery

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“…It was first defined in 1959 [1]. Cases were reported especially from North India [4][5][6]. This anomaly has recently been defined as having 4 types.…”

Section: Discussionmentioning

confidence: 98%

Abdominotransanal approach to pouch colon associated with rectal atresia

Kazez

Özel

Bakal

et al. 2009

Journal of Pediatric Surgery

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“…3 ) MM, muscularis mucosae; df, degrees of freedom; n.s., not significant; h.s., highly significant. 2 . This showed that ganglionic cells were present in all the CPC cases but that their numbers were reduced compared to in the controls.…”

Section: Resultsmentioning

confidence: 99%

“…The diagnosis of CPC was made based on the clinical and surgical findings. Based on the anatomic morphology of the pouch, CPC was classified according to the SaxenaMathur classification [2] .…”

Section: Methodsmentioning

confidence: 99%

Histopathological and Immunohistochemical Findings in Congenital Pouch Colon: A Prospective Study

Udawat¹,

Nunia²,

Mathur³

et al. 2017

Pathobiology

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Background: There is a paucity of literature on the histopathological aspects of congenital pouch colon (CPC) and immunohistochemical (IHC) assessment has not been reported. So we planned to study the histopathological and IHC findings within the spectrum of CPC and compare the findings with the normal colon. Methods: This is a descriptive prospective study on CPC patients. There were 49 cases of CPC (42 males and 7 females) and 13 controls. Histological examination was done using hematoxylin and eosin and Masson trichrome stain. IHC analysis was done with actin, myosin, and desmin antibodies, and neuron-specific enolase and S100 markers for counting ganglionic cells. Results: Histologically, congestion, edema and hemorrhage were seen in mucosa, submucosa, and serosa. Muscle layers were disrupted and divided into bands. An additional muscle coat inside of the muscularis propria was seen in CPC types 1 and 2. Mature ganglionic cells were reduced and muscle layers showed reduced and patchy positivity for smooth muscle actin, myosin, and desmin compared to a normal colon. Conclusions: Histopathological and IHC findings suggest that CPC has distinct defects in the neuromusculature.

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“…The diagnosis of CPC was made on clinical and surgical findings based on the anatomical morphology of the pouch. CPC was classified according to the Saxena-Mathur classification [13,14].…”

Section: Methodsmentioning

confidence: 99%

Congenital Pouch Colon: Role of Genetics or Environmental Influence?

Mathur¹,

Nunia²,

Sharma³

et al. 2018

Pathobiology

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Background: Congenital pouch colon (CPC), a high type of anorectal malformation, is a sporadic disease and several environmental factors are known to be involved in its pathology. To the best of our knowledge, no familial incidence of CPC has been reported anywhere in the literature so far. Aim: In the present study, which is first of its kind, we have reported the familial incidences of CPC and also tried to elucidate the role of genetics in this pathology. Methods: We have reported 1 familial pedigree of CPC and 2 incidences of dizygotic twins (DZ), out of them one is affected and another one is normal. Highly comprehensive microarray CytoScan HD from Affymetrix was employed to understand the defects underlying submicroscopic genomic imbalance like segment duplication and deletion of the twin patients vis-à-vis their parents and unaffected siblings in these DZ twins. Results: A total of 21 copy number variations (CNVs) were reported in the patient samples that did not overlap with the CNVs in normal parents and healthy sibling, including 5 loss, 3 LOH and 13 gain with size varied from 95 bp to 77 kbp. Genetic analysis revealed involvement of 12 potential genetic loci on Chr 1, 2, 3, 4, 6, 11, and 16. Conclusion: Genetic study found that CPC could be a developmental disorder. These findings are important for further elucidating genetic causes of CPC pathogenesis.

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Classification of congenital pouch colon based on anatomic morphology

Abstract: Classification based on the anatomic morphology has the advantage of identifying the pouch based on the segment of the colon involved, rather than the previous classification based on the length of the colon.

Cited by 36 publications

References 9 publications

Abdominotransanal approach to pouch colon associated with rectal atresia

Abdominotransanal approach to pouch colon associated with rectal atresia

Histopathological and Immunohistochemical Findings in Congenital Pouch Colon: A Prospective Study

Congenital Pouch Colon: Role of Genetics or Environmental Influence?

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