Citric acid crosslinked carboxymethylcellulose-polyvinyl alcohol hydrogel films for extended release of water soluble basic drugs

Ghorpade, Vishwajeet Sampatrao; Dias, Remeth J.; Mali, Kailas K.; Mulla, Safina Ismail

doi:10.1016/j.jddst.2019.05.013

Cited by 110 publications

(59 citation statements)

References 40 publications

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“…The first reported hydrogel can be traced back to 1960, when Wichterle and Lim synthesized poly (2-hydroxethyl methacrylate) (PHEMA) and utilized it in the contact lens industry with the ability of imbibing moisture while asserting its network structure, demonstrating the modern hydrogel [ 1 , 2 ]. Hydrogels, with their peculiar structure of three-dimensional crosslinked polymer meshwork, have the tendency to absorb considerable amounts of water within their interstices and keep bonding it while maintaining the network structure in the swollen state.…”

Section: Introduction Of Hydrogelsmentioning

confidence: 99%

Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications

et al. 2020

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In the present review, we focused on the fundamental concepts of hydrogels—classification, the polymers involved, synthesis methods, types of hydrogels, properties, and applications of the hydrogel. Hydrogels can be synthesized from natural polymers, synthetic polymers, polymerizable synthetic monomers, and a combination of natural and synthetic polymers. Synthesis of hydrogels involves physical, chemical, and hybrid bonding. The bonding is formed via different routes, such as solution casting, solution mixing, bulk polymerization, free radical mechanism, radiation method, and interpenetrating network formation. The synthesized hydrogels have significant properties, such as mechanical strength, biocompatibility, biodegradability, swellability, and stimuli sensitivity. These properties are substantial for electrochemical and biomedical applications. Furthermore, this review emphasizes flexible and self-healable hydrogels as electrolytes for energy storage and energy conversion applications. Insufficient adhesiveness (less interfacial interaction) between electrodes and electrolytes and mechanical strength pose serious challenges, such as delamination of the supercapacitors, batteries, and solar cells. Owing to smart and aqueous hydrogels, robust mechanical strength, adhesiveness, stretchability, strain sensitivity, and self-healability are the critical factors that can identify the reliability and robustness of the energy storage and conversion devices. These devices are highly efficient and convenient for smart, light-weight, foldable electronics and modern pollution-free transportation in the current decade.

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Section: Introduction Of Hydrogelsmentioning

confidence: 99%

Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications

et al. 2020

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“…A decrease in hydroxyl groups led to an increase in hydrophobicity of scaffolds, which resulted in less water absorption, as demonstrated by the very low swelling behaviors of all scaffolds at GA/PVA crosslinking ratio of 0.4. Besides GA, other crosslinking agents, such as epichlorohydrin [ 26 ] and citric acid [ 27 ], were used to crosslink PVA and CMC mixture under alkaline or acidic conditions at high temperature. These crosslinking reactions resulted in different products: crosslinked PVA–PVA, PVA–CMC, and CMC–CMC.…”

Section: Discussionmentioning

confidence: 99%

“…Compared to other fields, tissue engineering does not represent green and eco-friendly technologies because traditional scaffold fabrication processes still employ toxic solvents [ 44 ]. The use of plant-derived polysaccharides blended with PVA has emerged in biomedical applications, such as wound healing hydrogel [ 45 ], drug release hydrogel film [ 26 , 27 ], and cryogel scaffolds for bone tissue engineering [ 46 ]. Biocompatibility, biodegradability, and plant proteins abundant in nature (soy, zein, gluten) attract much attention as alternative scaffolding biomaterials for regenerative medicine.…”

Section: Discussionmentioning

confidence: 99%

Carboxymethyl Cellulose Entrapped in a Poly(vinyl) Alcohol Network: Plant-Based Scaffolds for Cartilage Tissue Engineering

et al. 2021

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Cartilage has a limited inherent healing capacity after injury, due to a lack of direct blood supply and low cell density. Tissue engineering in conjunction with biomaterials holds promise for generating cartilage substitutes that withstand stress in joints. A major challenge of tissue substitution is creating a functional framework to support cartilage tissue formation. Polyvinyl alcohol (PVA) was crosslinked with glutaraldehyde (GA), by varying the mole ratios of GA/PVA in the presence of different amounts of plant-derived carboxymethyl cellulose (CMC). Porous scaffolds were created by the freeze-drying technique. The goal of this study was to investigate how CMC incorporation and crosslinking density might affect scaffold pore formation, swelling behaviors, mechanical properties, and potential use for engineered cartilage. The peak at 1599 cm−1 of the C=O group in ATR–FTIR indicates the incorporation of CMC into the scaffold. The glass transition temperature (Tg) and Young’s modulus were lower in the PVA/CMC scaffold, as compared to the PVA control scaffold. The addition of CMC modulates the pore architecture and increases the swelling ratio of scaffolds. The toxicity of the scaffolds and cell attachment were tested. The results suggest that PVA/CMC scaffolding material can be tailored in terms of its physical and swelling properties to potentially support cartilage formation.

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“…Currently, numerous scientific researches on hydrogels as Drug Delivery Systems have been reported in [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Hydroxypropyl cellulose with polyacrylamide (HPC/PAAm) is a particularly interesting hydrogel because it is biodegradable.…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application

Díaz-Guerrero

Castillo-Miranda

Castro-Guerrero

et al. 2019

International Journal of Polymer Science

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Hydrogels are commonly used as Drug Delivery Systems (DDS) as patches due to its ability to store drug molecules within their structures. The release can be activated under certain stimuli, such as temperature and pH. In this paper, the mathematical modelling of acetaminophen release in hydroxypropyl cellulose with polyacrylamide (HPC/PAAm) is reported. The HPC/PAAm gel was synthesized in proportions of 25/75 wt% and was characterized by FTIR, DSC, optical microscopy, SEM, and TGA, with and without acetaminophen. The release tests were performed for hypothermic, normal, and febrile human body conditions, at 35, 37, and 39°C, respectively, on two release media: water and phosphate buffer solution. In order to describe the release of acetaminophen in HPC/PAAm gel, a genetic programming algorithm was used to accomplish Multigene Symbolic Regression (MSR). Characterization results showed that the drug was crystallized on the surface of the HPC/PAAm gel. Release test results showed that several simultaneous processes occurred in the acetaminophen diffusion phenomenon. A unique mathematical model was obtained by MSR. This model was able to describe the release of acetaminophen in HPC/PAAm gel with high values of R 2 and adjusted R 2 and to simulate the drug release at times beyond the end of the experiment. High values of R 2 and low values of Coefficient of Variation (CV), Root-Mean-Square Error (RMSE), and Mean Absolute Error (MAE) were obtained from the comparison between the simulated and the experimental data. This allows to conclude that the mathematical model is reliable to represent and simulate the acetaminophen release in HPC/PAAm gel at 35, 37, and 39°C.

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Citric acid crosslinked carboxymethylcellulose-polyvinyl alcohol hydrogel films for extended release of water soluble basic drugs

Cited by 110 publications

References 40 publications

Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications

Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications

Carboxymethyl Cellulose Entrapped in a Poly(vinyl) Alcohol Network: Plant-Based Scaffolds for Cartilage Tissue Engineering

Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application

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